Khk
Gene Detail

Symbol Name ID

Khk ketohexokinase MGI:1096353

Feature Type

protein coding gene

Genetic Map

Chromosome 5

16.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:30921556-30931246 bp, + strand From VEGA annotation of GRCm38   9691 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Khk

Human homologs

Human Homolog		KHK, ketohexokinase (fructokinase)
NCBI Gene ID		3795
neXtProt AC		NX_P50053
Human Chr (Location)		2p23.3; chr2:27309611-27323619 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KHK

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	carbohydrate metabolic process, fructose metabolic process, ...
Component	cytoplasm
Function	ATP binding, ketohexokinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (155)    Tissues (122)    Images (34)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	155

cDNA source data(143)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(145) cDNA(144) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030395 (Evidence)
Ensembl Gene Model	ENSMUSG00000029162 (Evidence)
Entrez Gene	16548 (Evidence)
UniGene	22451
DFCI	TC1576877
DoTS	DT.101158184, DT.493374
NIA Mouse Gene Index	U005430
EC	2.7.1.3
Consensus CDS Project	CCDS39050.1
International Mouse Knockout Project Status	Khk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030395	VEGA Gene Model | MGI Sequence Detail	9691	C57BL/6J
transcript	OTTMUST00000075287	VEGA | MGI Sequence Detail	1257	Not Applicable
polypeptide	OTTMUSP00000039428	VEGA | MGI Sequence Detail	343	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(86 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011611	PfkB
Protein Ontology	PR:000009282	ketohexokinase

References

(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:182240 Ishimoto T, et al., Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5
All references(36)