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Khk
Gene Detail
Symbol

Name
ID
Khk
ketohexokinase
MGI:1096353
Feature Type
protein coding gene
Genetic Map
Chromosome 5
16.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:30921556-30931246 bp, + strand
From VEGA annotation of GRCm38

  9691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KHK
Gene Tree: Khk

Human
homologs
KHK, ketohexokinase (fructokinase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3795
neXtProt AC: NX_P50053

Human Chr (Location): 2p23.3; chr2:27086743-27100751 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KHK

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Radiation induced(3) Targeted(6)
Genomic Mutations involving Khk (3)
Incidental mutations (data from APF )
 
Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Khk interacts with 31 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component cytoplasm, extracellular exosome, ...
Function ATP binding, ketohexokinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (155)    Tissues (122)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
cDNA source data(143)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN khk    NEW 
Molecular
reagents
All nucleic(145) cDNA(144) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030395 (Evidence)
Ensembl Gene Model ENSMUSG00000029162 (Evidence)
Entrez Gene 16548 (Evidence)
UniGene 22451
DFCI TC1576877
DoTS DT.101158184, DT.493374
NIA Mouse Gene Index U005430
EC 2.7.1.3
Consensus CDS Project CCDS39050.1
International Mouse Phenotyping Consortium Status Khk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030395 VEGA Gene Model | MGI Sequence Detail 9691 C57BL/6J ±  kb
transcript OTTMUST00000075287 VEGA | MGI Sequence Detail 1257 Not Applicable 
polypeptide OTTMUSP00000039428 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011611 Carbohydrate kinase PfkB
Protein Ontology PR:000009282 ketohexokinase
References
(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:182240 Ishimoto T, et al., Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory