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Khk Gene Detail
Summary
  • Symbol
    Khk
  • Name
    ketohexokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096353
    NCBI Gene: 16548
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30921436-30931248 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096353
protein coding gene Chr5:30921431-30931248 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029401
protein coding gene Chr5:28880228-28890042 (+)
A/J MGP_AJ_G0029367
protein coding gene Chr5:27943366-27953232 (+)
AKR/J MGP_AKRJ_G0029318
protein coding gene Chr5:29094930-29104757 (+)
BALB/cJ MGP_BALBcJ_G0029378
protein coding gene Chr5:28464749-28474568 (+)
C3H/HeJ MGP_C3HHeJ_G0029099
protein coding gene Chr5:29092922-29102739 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029831
protein coding gene Chr5:30658012-30667858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027069
protein coding gene Chr5:25420916-25431282 (+)
CAST/EiJ MGP_CASTEiJ_G0028510
protein coding gene Chr5:28186468-28196257 (+)
CBA/J MGP_CBAJ_G0029067
protein coding gene Chr5:31231810-31241628 (+)
DBA/2J MGP_DBA2J_G0029216
protein coding gene Chr5:28125221-28135044 (+)
FVB/NJ MGP_FVBNJ_G0029174
protein coding gene Chr5:27538922-27549059 (+)
LP/J MGP_LPJ_G0029301
protein coding gene Chr5:29344078-29353900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029203
protein coding gene Chr5:32124594-32134446 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029865
protein coding gene Chr5:28594857-28604674 (+)
PWK/PhJ MGP_PWKPhJ_G0028234
protein coding gene Chr5:27242980-27252784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028064
protein coding gene Chr5:27967691-27977522 (+)
WSB/EiJ MGP_WSBEiJ_G0028590
protein coding gene Chr5:28660155-28669974 (+)



Homology
more
  • Human Ortholog
    KHK, ketohexokinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KHK, ketohexokinase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3795
    neXtProt AC: NX_P50053
    UniProt: P50053

  • Chr Location
    2p23.3; chr2:27086738-27100751 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38187
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KHK
  • Gene Tree
    Khk
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    5 involving Khk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16548 NCBI Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
transcript NM_001310524 RefSeq | MGI Sequence Detail 1590 C57BL/6  
polypeptide P97328 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    cDNA 145
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 63
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 10
    Phenotypes 34
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:253776 Kishida K, et al., Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G592-G605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory