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Khk Gene Detail
Summary
  • Symbol
    Khk
  • Name
    ketohexokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096353
    NCBI Gene: 16548
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31078780-31088592 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096353
protein coding gene Chr5:31078775-31088592 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029401
protein coding gene Chr5:28880228-28890042 (+)
A/J MGP_AJ_G0029367
protein coding gene Chr5:27943366-27953232 (+)
AKR/J MGP_AKRJ_G0029318
protein coding gene Chr5:29094930-29104757 (+)
BALB/cJ MGP_BALBcJ_G0029378
protein coding gene Chr5:28464749-28474568 (+)
C3H/HeJ MGP_C3HHeJ_G0029099
protein coding gene Chr5:29092922-29102739 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029831
protein coding gene Chr5:30658012-30667858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027069
protein coding gene Chr5:25420916-25431282 (+)
CAST/EiJ MGP_CASTEiJ_G0028510
protein coding gene Chr5:28186468-28196257 (+)
CBA/J MGP_CBAJ_G0029067
protein coding gene Chr5:31231810-31241628 (+)
DBA/2J MGP_DBA2J_G0029216
protein coding gene Chr5:28125221-28135044 (+)
FVB/NJ MGP_FVBNJ_G0029174
protein coding gene Chr5:27538922-27549059 (+)
LP/J MGP_LPJ_G0029301
protein coding gene Chr5:29344078-29353900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029203
protein coding gene Chr5:32124594-32134446 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029865
protein coding gene Chr5:28594857-28604674 (+)
PWK/PhJ MGP_PWKPhJ_G0028234
protein coding gene Chr5:27242980-27252784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028064
protein coding gene Chr5:27967691-27977522 (+)
WSB/EiJ MGP_WSBEiJ_G0028590
protein coding gene Chr5:28660155-28669974 (+)



Homology
more
  • Human Ortholog
    KHK, ketohexokinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KHK, ketohexokinase
  • Synonyms
    FRUCTU
  • Links
    NCBI Gene ID: 3795
    neXtProt AC: NX_P50053
    UniProt: P50053

  • Chr Location
    2p23.3; chr2:27086772-27100762 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human KHK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    58 phenotype references
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    9
  • Genomic Mutations
    5 involving Khk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16548 NCBI Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
transcript NM_001310524 RefSeq | MGI Sequence Detail 1590 ZRU/MplStud  
polypeptide P97328 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    cDNA 145
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 90
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 17
    Phenotypes 58
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:338902 Guccini I, et al., Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development. iScience. 2023 Aug 18;26(8):107368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory