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E2f3
Gene Detail
 Symbol
Name
ID
E2f3
E2F transcription factor 3
MGI:1096340
Synonyms E2f3a, E2F3b, mKIAA0075
Feature Type protein coding gene
Genetic Map
Chromosome 13
13.09 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:29906575-29985668 bp, - strand
From VEGA annotation of GRCm38

  79094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f3

Human
homologs
Human Homolog E2F3, E2F transcription factor 3
NCBI Gene ID 1871
neXtProt AC  NX_O00716
Human Synonyms  E2F-3
Human Chr (Location)  6p22; chr6:20401906-20493714 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(15) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased lethality prior to adulthood but otherwise appear normal. Mouse embryonic fibroblast cells from mice homozygous for a null allele are defective in cell cycle progression and exhibit reduced proliferation.
 
Interactions
E2f3 interacts with 418 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell cycle, positive regulation of cell proliferation, ...
Component cytoplasm, Golgi apparatus, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (260)    Tissues (213)    Images (27)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 214
Western blot 38
RT-PCR 8
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(77) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000000738 (Evidence)
Ensembl Gene ModelENSMUSG00000016477 (Evidence)
Entrez Gene13557 (Evidence)
UniGene268356
DFCITC1583614, TC1599666, TC1616161, TC1620675, TC1630347, TC1677900
DoTSDT.101300980, DT.110969570, DT.490486, DT.97352410, DT.97391541
NIA Mouse Gene IndexU034654
Consensus CDS ProjectCCDS26413.1
International Mouse Knockout Project StatusE2f3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000738 VEGA Gene Model | MGI Sequence Detail 79094 C57BL/6J ±  kb
transcript OTTMUST00000001388 VEGA | MGI Sequence Detail 4702 Not Applicable 
polypeptide OTTMUSP00000000663 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(391 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006854 transcription factor E2F3
References (Earliest) J:125251 Karlseder J, et al., Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr;16(4):1659-67
(Latest) J:204212 Zhou J, et al., Contrasting roles of E2F2 and E2F3 in cardiac neovascularization. PLoS One. 2013;8(6):e65755
All references(100)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory