Mesp2
Gene Detail

Symbol Name ID

Mesp2 mesoderm posterior 2 MGI:1096325

Synonyms

bHLHc6

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:79810727-79813431 bp, + strand From NCBI annotation of GRCm38   2705 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 chicken

Gene Tree: Mesp2

Human homologs

Human Homolog		MESP2, mesoderm posterior 2 homolog (mouse)
NCBI Gene ID		145873
neXtProt AC		NX_Q0VG99
Human Synonyms		bHLHc6, SCDO2
Human Chr (Location)		15q26.1; chr15:90319589-90321985 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MESP2

Alleles and phenotypes

All alleles(21) : Targeted(20) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	mesodermal cell migration, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (69 records)
Data Summary: Results (116)    Tissues (52)    Images (56)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	96
In situ reporter (knock in)	4
RT-PCR	16

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(14) Primer pair(3) Other(6)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030543 (Evidence)
Entrez Gene	17293 (Evidence)
UniGene	31472
DFCI	TC1585780
DoTS	DT.529704
NIA Mouse Gene Index	U043946
Consensus CDS Project	CCDS39993.1
International Mouse Knockout Project Status	Mesp2

Sequences

Length	Strain/Species
genomic	17293	NCBI Gene Model | MGI Sequence Detail	2705	C57BL/6J
transcript	NM_008589	RefSeq | MGI Sequence Detail	1936	C57BL/6
polypeptide	O08574	UniProt | EBI | MGI Sequence Detail	370	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000010333	mesoderm posterior protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:42014 Saga Y, et al., Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997 Jul 15;11(14):1827-39
(Latest) J:193853 Makino Y, et al., Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis. Bone. 2013 Mar;53(1):248-58
All references(99)