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Mesp2 Gene Detail
Summary
  • Symbol
    Mesp2
  • Name
    mesoderm posterior 2
  • Synonyms
    bHLHc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096325
    NCBI Gene: 17293
  • Gene Overview
    MyGene.info: MESP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79810727-79813431 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096325
protein coding gene Chr7:79810727-79813439 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032397
protein coding gene Chr7:81723691-81726403 (+)
A/J MGP_AJ_G0032376
protein coding gene Chr7:79829358-79832070 (+)
AKR/J MGP_AKRJ_G0032312
protein coding gene Chr7:81555731-81558443 (+)
BALB/cJ MGP_BALBcJ_G0032388
protein coding gene Chr7:79522242-79524954 (+)
C3H/HeJ MGP_C3HHeJ_G0032101
protein coding gene Chr7:82199532-82202244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032880
protein coding gene Chr7:84931013-84933725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029888
protein coding gene Chr7:82363591-82366314 (+)
CAST/EiJ MGP_CASTEiJ_G0031429
protein coding gene Chr7:73079989-73082700 (+)
CBA/J MGP_CBAJ_G0032067
protein coding gene Chr7:87773089-87775801 (+)
DBA/2J MGP_DBA2J_G0032222
protein coding gene Chr7:78396505-78399217 (+)
FVB/NJ MGP_FVBNJ_G0032177
protein coding gene Chr7:78309749-78312461 (+)
LP/J MGP_LPJ_G0032303
protein coding gene Chr7:82978667-82981379 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032214
protein coding gene Chr7:87931682-87934394 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032898
protein coding gene Chr7:80992126-80994838 (+)
PWK/PhJ MGP_PWKPhJ_G0031149
protein coding gene Chr7:71573001-71575712 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030990
protein coding gene Chr7:67998342-68001023 (+)
WSB/EiJ MGP_WSBEiJ_G0031547
protein coding gene Chr7:81315408-81318120 (+)



Homology
more
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHc6, SCDO2
  • Links
    NCBI Gene ID: 145873
    neXtProt AC: NX_Q0VG99
    UniProt: Q0VG99

  • Chr Location
    15q26.1; chr15:89776358-89778754 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MESP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 14 alleles in 6 genetic backgrounds
    20 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17293 NCBI Gene Model | MGI Sequence Detail 2705 C57BL/6J ±  kb
    transcript NM_008589 RefSeq | MGI Sequence Detail 1936 C57BL/6  
    polypeptide O08574 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 16
      Primer pair 3
      Other 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 84
      Gene Ontology 8
      Phenotypes 37
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:258120 Sonnen KF, et al., Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation. Cell. 2018 Feb 22;172(5):1079-1090.e12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory