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Mesp2
Gene Detail
Symbol

Name
ID
Mesp2
mesoderm posterior 2
MGI:1096325
Synonyms
bHLHc6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79810727-79813431 bp, + strand
From NCBI annotation of GRCm38

  2705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mesp2

Human
homologs
Human Homolog MESP2, mesoderm posterior basic helix-loop-helix transcription factor 2
NCBI Gene ID 145873
neXtProt AC  NX_Q0VG99
Human Synonyms  bHLHc6, SCDO2
Human Chr (Location)  15q26.1; chr15:89776358-89778754 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MESP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(1) Targeted(21)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.
 
Interactions
Mesp2 interacts with 93 markers (Mir27a, Mir27b, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process mesodermal cell migration, multicellular organismal development, ...
Component extracellular vesicular exosome, nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (169)    Tissues (98)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
In situ reporter (knock in) 4
RT-PCR 9
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(14) Primer pair(3) Other(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030543 (Evidence)
Entrez Gene17293 (Evidence)
UniGene31472
DFCITC1585780
DoTSDT.529704
NIA Mouse Gene IndexU043946
Consensus CDS ProjectCCDS39993.1
International Mouse Knockout Project StatusMesp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17293 NCBI Gene Model | MGI Sequence Detail 2705 C57BL/6J ±  kb
transcript NM_008589 RefSeq | MGI Sequence Detail 1936 C57BL/6 
polypeptide O08574 UniProt | EBI | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010333 mesoderm posterior protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:42014 Saga Y, et al., Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997 Jul 15;11(14):1827-39
(Latest) J:208899 Williams DR, et al., Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis. Dev Biol. 2014 Apr 15;388(2):159-69
All references(105)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory