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Mesp2 Gene Detail
Summary
  • Symbol
    Mesp2
  • Name
    mesoderm posterior 2
  • Synonyms
    bHLHc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096325
    NCBI Gene: 17293
  • Gene Overview
    MyGene.info: MESP2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:79810727-79813439 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2713 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.18 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc6, SCDO2
  • Links
    NCBI Gene ID: 145873
    neXtProt AC: NX_Q0VG99
    UniProt: Q0VG99

  • Chr Location
    15q26.1; chr15:89776358-89778754 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MESP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 14 alleles in 6 genetic backgrounds
    20 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058591 VEGA Gene Model | MGI Sequence Detail 2713 C57BL/6J ±  kb
    transcript OTTMUST00000143871 VEGA | MGI Sequence Detail 1944 Not Applicable  
    polypeptide OTTMUSP00000075000 VEGA | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
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    • All nucleic 27
      cDNA 16
      Primer pair 3
      Other 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 83
      Gene Ontology 7
      Phenotypes 37
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:258120 Sonnen KF, et al., Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation. Cell. 2018 Feb 22;172(5):1079-1090.e12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory