About   Help   FAQ
Mesp2
Gene Detail
Symbol

Name
ID
Mesp2
mesoderm posterior 2
MGI:1096325
Synonyms
bHLHc6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79810727-79813431 bp, + strand
From NCBI annotation of GRCm38

  2705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MESP2
Gene Tree: Mesp2

Human
homologs
MESP2, mesoderm posterior bHLH transcription factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 145873
neXtProt AC: NX_Q0VG99

Human Synonyms: bHLHc6, SCDO2

Human Chr (Location): 15q26.1; chr15:89776358-89778754 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MESP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(1) Targeted(21)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.
 
Interactions
Mesp2 interacts with 93 markers (Mir27a, Mir27b, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process mesodermal cell migration, multicellular organismal development, ...
Component extracellular exosome, nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (169)    Tissues (98)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
In situ reporter (knock in) 4
RT-PCR 9
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MESP2    NEW 
Molecular
reagents
All nucleic(24) cDNA(14) Primer pair(3) Other(7)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030543 (Evidence)
Entrez Gene 17293 (Evidence)
UniGene 31472
DFCI TC1585780
DoTS DT.529704
NIA Mouse Gene Index U043946
Consensus CDS Project CCDS39993.1
International Mouse Phenotyping Consortium Status Mesp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17293 NCBI Gene Model | MGI Sequence Detail 2705 C57BL/6J ±  kb
transcript NM_008589 RefSeq | MGI Sequence Detail 1936 C57BL/6 
polypeptide O08574 UniProt | EBI | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010333 mesoderm posterior protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:42014 Saga Y, et al., Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997 Jul 15;11(14):1827-39
(Latest) J:220849 Achilleos A, et al., MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral developmentdagger. Hum Mol Genet. 2015 May 15;24(10):2884-98
All references(107)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory