Eef1a2
Gene Detail

Symbol Name ID

Eef1a2 eukaryotic translation elongation factor 1 alpha 2 MGI:1096317

Synonyms

Eef1a, S1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

103.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr2:181147653-181157014 bp, - strand From VEGA annotation of GRCm38   9362 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:121568  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 3 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: translation elongation factor Tu
Gene Tree: Eef1a2

Human homologs

Human Homolog		EEF1A2, eukaryotic translation elongation factor 1 alpha 2
NCBI Gene ID		1917
neXtProt AC		NX_Q05639
Human Synonyms		EEF1AL, EF1A, EF-1-alpha-2, HS1, STN, STNL
Human Chr (Location)		20q13.3; chr20:63488012-63499315 (-)  GRCh38

Alleles and phenotypes

All alleles(1) : Spontaneous(1)
Incidental mutations (data from APF )
 

Homozygotes for a spontaneous mutation exhibit muscle wasting, lymphoid hypoplasia, lack of intestinal IgA plasma cells, cerebellar dysfunction, neurodegeneration, an age-dependent increase in chromosomal aberrations, and lethality around 28 days of age.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	positive regulation of apoptotic process, translation, ...
Component	cytoplasm, eukaryotic translation elongation factor 1 complex, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (89)    Tissues (68)    Images (14)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43
RT-PCR	46

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(3) cDNA(4) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016559 (Evidence)
Ensembl Gene Model	ENSMUSG00000016349 (Evidence)
Entrez Gene	13628 (Evidence)
DFCI	TC1575634, TC1601096, TC1608352
DoTS	DT.492434, DT.87035267
NIA Mouse Gene Index	U023776, U280666
Consensus CDS Project	CCDS17201.1
International Mouse Knockout Project Status	Eef1a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016559	VEGA Gene Model | MGI Sequence Detail	9362	C57BL/6J
transcript	OTTMUST00000040035	VEGA | MGI Sequence Detail	2084	Not Applicable
polypeptide	OTTMUSP00000017863	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(33 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000795	Elongation factor, GTP-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR004539	Translation elongation factor EF1A, eukaryotic/archaeal
InterPro	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
InterPro	IPR004160	Translation elongation factor EFTu/EF1A, C-terminal
InterPro	IPR004161	Translation elongation factor EFTu/EF1A, domain 2
InterPro	IPR009000	Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology	PR:000006904	elongation factor 1-alpha 2

References

(Earliest) J:24753 Sweet HO, Wasted (wst). Mouse News Lett. 1981;65:27
(Latest) J:189690 Griffiths LA, et al., Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function. PLoS One. 2012;7(7):e41917
All references(64)

Other accession IDs

MGD-MRK-15461, MGD-MRK-9306, MGI:95287, MGI:98966