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Eef1a2
Gene Detail
Symbol

Name
ID
Eef1a2
eukaryotic translation elongation factor 1 alpha 2
MGI:1096317
Synonyms
Eef1a, S1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:181147653-181157014 bp, - strand
From VEGA annotation of GRCm38

  9362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121568  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 3 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EEF1A2
Protein SuperFamily: translation elongation factor Tu
Gene Tree: Eef1a2

Human
homologs
EEF1A2, eukaryotic translation elongation factor 1 alpha 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1917
neXtProt AC: NX_Q05639

Human Synonyms: EEF1AL, EF1A, EF-1-alpha-2, EIEE33, HS1, MRD38, STN, STNL

Human Chr (Location): 20q13.3; chr20:63488012-63499315 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EEF1A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from APF )
 
Homozygotes for a spontaneous mutation exhibit muscle wasting, lymphoid hypoplasia, lack of intestinal IgA plasma cells, cerebellar dysfunction, neurodegeneration, an age-dependent increase in chromosomal aberrations, and lethality around 28 days of age.
 
Interactions
Eef1a2 interacts with 44 markers (Mir100, Mir137, Mir143, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (89)    Tissues (68)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 46
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eef1a2    NEW 
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(4) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016559 (Evidence)
Ensembl Gene Model ENSMUSG00000016349 (Evidence)
Entrez Gene 13628 (Evidence)
DFCI TC1575634, TC1601096, TC1608352
DoTS DT.492434, DT.87035267
NIA Mouse Gene Index U023776, U280666
Consensus CDS Project CCDS17201.1
International Mouse Phenotyping Consortium Status Eef1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016559 VEGA Gene Model | MGI Sequence Detail 9362 C57BL/6J ±  kb
transcript OTTMUST00000040035 VEGA | MGI Sequence Detail 2084 Not Applicable 
polypeptide OTTMUSP00000017863 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000795 Elongation factor, GTP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
InterPro IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
InterPro IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
InterPro IPR004161 Translation elongation factor EFTu/EF1A, domain 2
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000006904 elongation factor 1-alpha 2
References
(Earliest) J:24753 Sweet HO, Wasted (wst). Mouse News Lett. 1981;65:27
(Latest) J:189690 Griffiths LA, et al., Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function. PLoS One. 2012;7(7):e41917
All references(64)
Other
accession IDs
MGD-MRK-15461, MGD-MRK-9306, MGI:95287, MGI:98966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory