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Taz Gene Detail
Summary
  • Symbol
    Taz
  • Name
    tafazzin
  • Synonyms
    5031411C02Rik, 9130012G04Rik, G4.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109626
    NCBI Gene: 66826
  • Gene Overview
    MyGene.info: TAZ
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74281912-74290151 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.95 cM, cytoband C1-C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109626
protein coding gene ChrX:74281900-74295319 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035838
protein coding gene ChrX:70079651-70087890 (+)
A/J MGP_AJ_G0035819
protein coding gene ChrX:70265908-70274258 (+)
AKR/J MGP_AKRJ_G0035744
protein coding gene ChrX:72167676-72175915 (+)
BALB/cJ MGP_BALBcJ_G0035804
protein coding gene ChrX:69291216-69299455 (+)
C3H/HeJ MGP_C3HHeJ_G0035509
protein coding gene ChrX:70555483-70563722 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036334
protein coding gene ChrX:72241122-72249361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033178
protein coding gene ChrX:69331447-69339867 (+)
CAST/EiJ MGP_CASTEiJ_G0034800
protein coding gene ChrX:55935101-55943974 (+)
CBA/J MGP_CBAJ_G0035484
protein coding gene ChrX:74235699-74243938 (+)
DBA/2J MGP_DBA2J_G0035641
protein coding gene ChrX:69725440-69733679 (+)
FVB/NJ MGP_FVBNJ_G0035585
protein coding gene ChrX:69068915-69077154 (+)
LP/J MGP_LPJ_G0035726
protein coding gene ChrX:70860619-70868858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035623
protein coding gene ChrX:76801701-76810143 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036356
protein coding gene ChrX:69897904-69906143 (+)
PWK/PhJ MGP_PWKPhJ_G0034499
protein coding gene ChrX:53896831-53905095 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034333
protein coding gene ChrX:56805472-56813771 (+)
WSB/EiJ MGP_WSBEiJ_G0034941
protein coding gene ChrX:69180503-69188945 (+)



Homology
more
  • Human Ortholog
    TAZ, tafazzin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TAZ, tafazzin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1
  • Links
    NCBI Gene ID: 6901
    neXtProt AC: NX_Q16635
    UniProt: Q16635

  • Chr Location
    Xq28; chrX:154411406-154421726 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37264
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TAZ
  • Gene Tree
    Taz
Human Diseases
more
  • Diseases
    1 with human TAZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with small testes, azoospermia and abnormal spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009995 Ensembl Gene Model | MGI Sequence Detail 8240 C57BL/6J ±  kb
    transcript ENSMUST00000114180 Ensembl | MGI Sequence Detail 1786 Not Applicable  
    polypeptide ENSMUSP00000109818 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • InterPro Domains
      IPR002123 Phospholipid/glycerol acyltransferase
      IPR000872 Tafazzin
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 6
      cDNA 17

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39625, MGI:1914076, MGI:1926060, MGI:2147995, MGI:2148024
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
    • Latest
      J:264380 Artap S, et al., Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018 Aug 1;440(1):22-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory