Tafazzin^em1Xfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tafazzin^em1Xfa
• Name: tafazzin, phospholipid-lysophospholipid transacylase; endonuclease-mediated mutation 1, Xi Fang
• MGI ID: MGI:7520216
• Synonyms: Taz^F
• Gene: Tafazzin Location: ChrX:73325518-73333757 bp, + strand Genetic Position: ChrX, 37.95 cM, cytoband C1-C3
• Alliance: Tafazzin^em1Xfa page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 5 to 10 were flanked by loxP sites via CRISPR/Cas9 technology. (J:339058)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tafazzin Mutation: 3 strains or lines available

References

• Original: J:339058 Zhu S, et al., Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy. Circ Heart Fail. 2021 Jun;14(6):e008289
• All: 2 reference(s)