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Plk3
Gene Detail
 Symbol
Name
ID
Plk3
polo-like kinase 3
MGI:109604
Synonyms Cnk
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.41 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr4:117128655-117133963 bp, - strand
From VEGA annotation of GRCm38

  5309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Plk3

Human
homologs
Human Homolog PLK3, polo-like kinase 3
NCBI Gene ID 1263
neXtProt AC  NX_Q9H4B4
Human Synonyms  CNK, FNK, PRK
Human Chr (Location)  1p34.1; chr1:44799961-44805995 (+)  GRCh38
Alleles
and
phenotypes
All alleles(17) : Gene trapped(9) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Aged mice homozygous for a null allele develop tumors in various organs at an accelerated rate while mouse embryonic fibroblasts are hypersensitive to the induction of HIF-1alpha under hypoxic conditions or by nickel and cobalt ion treatments. Homozygotes for another null allele are overtly normal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process apoptotic process, cell cycle, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (43)    Tissues (29)    Images (14)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 43
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009922 (Evidence)
Ensembl Gene ModelENSMUSG00000028680 (Evidence)
Entrez Gene12795 (Evidence)
NIA Mouse Gene IndexU025426
EC2.7.11.21
Consensus CDS ProjectCCDS18529.1
International Mouse Knockout Project StatusPlk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009922 VEGA Gene Model | MGI Sequence Detail 5309 C57BL/6J ±  kb
transcript OTTMUST00000023046 VEGA | MGI Sequence Detail 2378 Not Applicable 
polypeptide OTTMUSP00000010513 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000959 POLO box duplicated domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR020658 Serine/threonine-protein kinase Plk3
Protein Ontology PR:000012872 serine/threonine-protein kinase PLK3
References (Earliest) J:24944 Donohue PJ, et al., Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem. 1995 Apr 28;270(17):10351-7
(Latest) J:201467 Bergeron M, et al., In Vivo Modulation of Polo-Like Kinases (PLK) Supports a Key Role for PLK2 in Ser129 alpha-Synuclein Phosphorylation in Mouse Brain. Neuroscience. 2014;256:72-82
All references(45)
Other
accession IDs
MGD-MRK-39603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory