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Plk3
Gene Detail
Symbol

Name
ID
Plk3
polo-like kinase 3
MGI:109604
Synonyms
Cnk
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.41 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr4:117128655-117133963 bp, - strand
From VEGA annotation of GRCm38

  5309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLK3
Gene Tree: Plk3

Human
homologs
PLK3, polo-like kinase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1263
neXtProt AC: NX_Q9H4B4

Human Synonyms: CNK, FNK, PRK

Human Chr (Location): 1p34.1; chr1:44799952-44805995 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(9) Targeted(9)
Genomic Mutations involving Plk3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Aged mice homozygous for a null allele develop tumors in various organs at an accelerated rate while mouse embryonic fibroblasts are hypersensitive to the induction of HIF-1alpha under hypoxic conditions or by nickel and cobalt ion treatments. Homozygotes for another null allele are overtly normal.
 
Interactions
Plk3 interacts with 81 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process apoptotic process, cell cycle, ...
Component centrosome, chromatin, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (43)    Tissues (29)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase plk3    NEW 
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009922 (Evidence)
Ensembl Gene Model ENSMUSG00000028680 (Evidence)
Entrez Gene 12795 (Evidence)
NIA Mouse Gene Index U025426
EC 2.7.11.21
Consensus CDS Project CCDS18529.1
International Mouse Phenotyping Consortium Status Plk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009922 VEGA Gene Model | MGI Sequence Detail 5309 C57BL/6J ±  kb
transcript OTTMUST00000023046 VEGA | MGI Sequence Detail 2378 Not Applicable 
polypeptide OTTMUSP00000010513 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000959 POLO box duplicated domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR020658 Serine/threonine-protein kinase Plk3
Protein Ontology PR:000012872 serine/threonine-protein kinase PLK3
References
(Earliest) J:24944 Donohue PJ, et al., Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem. 1995 Apr 28;270(17):10351-7
(Latest) J:217760 Wang L, et al., Osmotic stress-induced phosphorylation of H2AX by polo-like kinase 3 affects cell cycle progression in human corneal epithelial cells. J Biol Chem. 2014 Oct 24;289(43):29827-35
All references(45)
Other
accession IDs
MGD-MRK-39603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory