About   Help   FAQ
Sf3b4
Gene Detail
Symbol

Name
ID
Sf3b4
splicing factor 3b, subunit 4
MGI:109580
Synonyms
49kDa, MGC:36369, MGC:36564, Sap49, SF3b49
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:96172332-96177564 bp, + strand
From VEGA annotation of GRCm38

  5233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sf3b4

Human
homologs
Human Homolog SF3B4, splicing factor 3b, subunit 4, 49kDa
NCBI Gene ID 10262
neXtProt AC  NX_Q15427
Human Synonyms  AFD1, Hsh49, SAP49, SF3b49
Human Chr (Location)  1q21.2; chr1:149923317-149929322 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SF3B4
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(27) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sf3b4 interacts with 105 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process mRNA processing, positive regulation of mRNA splicing, via spliceosome, ...
Component nucleus, spliceosomal complex, ...
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (51)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 14
RT-PCR 2
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021896 (Evidence)
Ensembl Gene ModelENSMUSG00000068856 (Evidence)
Entrez Gene107701 (Evidence)
UniGene219671
DFCITC1574620
DoTSDT.532837, DT.97370559
Consensus CDS ProjectCCDS17630.1
International Mouse Knockout Project StatusSf3b4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021896 VEGA Gene Model | MGI Sequence Detail 5233 C57BL/6J ±  kb
transcript OTTMUST00000051999 VEGA | MGI Sequence Detail 1915 Not Applicable 
polypeptide OTTMUSP00000024556 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000014738 splicing factor 3B subunit 4
References
(Earliest) J:39334 Ruiz-Lozano P, et al., Developmental expression of the murine spliceosome-associated protein mSAP49. Dev Dyn. 1997 Apr;208(4):482-90
(Latest) J:204486 Zheng S, et al., A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013 Jun;23(6):998-1007
All references(34)
Other
accession IDs
MGD-MRK-39579

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory