Tulp1
Gene Detail

Symbol Name ID

Tulp1 tubby like protein 1 MGI:109571

Synonyms

Tulp1l

Feature Type

protein coding gene

Genetic Map

Chromosome 17

14.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:28351515-28365182 bp, - strand From VEGA annotation of GRCm38   13668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tubby protein
Gene Tree: Tulp1

Human homologs

Human Homolog		TULP1, tubby like protein 1
NCBI Gene ID		7287
neXtProt AC		NX_O00294
Human Synonyms		LCA15, RP14, TUBL1
Human Chr (Location)		6p21.3; chr6:35497874-35512902 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human TULP1

Alleles and phenotypes

All alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix )
 

Homozygous mutant mice exhibit retinal degeneration.

 
Human Diseases Modeled Using Mouse Tulp1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	dendrite development, detection of light stimulus involved in visual perception, ...
Component	cell junction, cell projection, ...
Function	actin filament binding, G-protein coupled photoreceptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (12)    Tissues (12)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	12

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) cDNA(57)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024252 (Evidence)
Ensembl Gene Model	ENSMUSG00000037446 (Evidence)
Entrez Gene	22157 (Evidence)
UniGene	42102
DFCI	TC1595861, TC1601092, TC1605438, TC1605529, TC1618308, TC1639644
DoTS	DT.101369781, DT.101723313, DT.110568520, DT.110568525, DT.40141309, DT.91366291, DT.91583599
NIA Mouse Gene Index	U037606
Consensus CDS Project	CCDS28578.1
International Mouse Knockout Project Status	Tulp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024252	VEGA Gene Model | MGI Sequence Detail	13668	C57BL/6J
transcript	OTTMUST00000059359	VEGA | MGI Sequence Detail	2017	Not Applicable
polypeptide	OTTMUSP00000028868	VEGA | MGI Sequence Detail	543	Not Applicable

All sequences(70) RefSeq(4) UniProt(6)

Polymorphisms

SNPs within 2kb(31 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000007	Tubby, C-terminal
InterPro	IPR018066	Tubby, C-terminal, conserved site
InterPro	IPR025659	Tubby C-terminal-like domain
Protein Ontology	PR:000016834	tubby-related protein 1

References

(Earliest) J:39282 North MA, et al., Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33
(Latest) J:196742 Maddox DM, et al., An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice. Invest Ophthalmol Vis Sci. 2012 Mar;53(3):1663-9
All references(44)

Other accession IDs

MGD-MRK-39570