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Tulp1
Gene Detail
 Symbol
Name
ID
Tulp1
tubby like protein 1
MGI:109571
Synonyms Tulp1l
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:28351515-28365182 bp, - strand
From VEGA annotation of GRCm38

  13668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tubby protein
Gene Tree: Tulp1

Human
homologs
Human Homolog TULP1, tubby like protein 1
NCBI Gene ID 7287
neXtProt AC  NX_O00294
Human Synonyms  LCA15, RP14, TUBL1
Human Chr (Location)  6p21.3; chr6:35497874-35512902 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TULP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutant mice exhibit retinal degeneration.
 
Human Diseases Modeled Using Mouse Tulp1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tulp1 interacts with 46 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process dendrite development, detection of light stimulus involved in visual perception, ...
Component cell junction, cell projection, ...
Function actin filament binding, G-protein coupled photoreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (12)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 12
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024252 (Evidence)
Ensembl Gene ModelENSMUSG00000037446 (Evidence)
Entrez Gene22157 (Evidence)
UniGene42102
DFCITC1595861, TC1601092, TC1605438, TC1605529, TC1618308, TC1639644
DoTSDT.101369781, DT.101723313, DT.110568520, DT.110568525, DT.40141309, DT.91366291, DT.91583599
NIA Mouse Gene IndexU037606
Consensus CDS ProjectCCDS28578.1
International Mouse Knockout Project StatusTulp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024252 VEGA Gene Model | MGI Sequence Detail 13668 C57BL/6J ±  kb
transcript OTTMUST00000059359 VEGA | MGI Sequence Detail 2017 Not Applicable 
polypeptide OTTMUSP00000028868 VEGA | MGI Sequence Detail 543 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000007 Tubby, C-terminal
InterPro IPR018066 Tubby, C-terminal, conserved site
InterPro IPR025659 Tubby C-terminal-like domain
Protein Ontology PR:000016834 tubby-related protein 1
References (Earliest) J:39282 North MA, et al., Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33
(Latest) J:196742 Maddox DM, et al., An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice. Invest Ophthalmol Vis Sci. 2012 Mar;53(3):1663-9
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory