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Kmt2b
Gene Detail
 Symbol
Name
ID
Kmt2b
lysine (K)-specific methyltransferase 2B
MGI:109565
Synonyms 2610014H22Rik, mKIAA0304, Mll2, Wbp7
Feature Type protein coding gene
Genetic Map
Chromosome 7
18.63 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:30568858-30588726 bp, - strand
From VEGA annotation of GRCm38

  19869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Kmt2b

Human
homologs
Human Homolog KMT2B, lysine (K)-specific methyltransferase 2B
NCBI Gene ID 9757
neXtProt AC  NX_Q9UMN6
Human Synonyms  HRX2, MLL1B, MLL2, MLL4, TRX2, WBP7, WBP-7
Human Chr (Location)  19q13.1; chr19:35718019-35738878 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(2) Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene leads to embryonic growth retardation, abnormal somite development, neural tube defects, increased apoptosis, and complete embryonic lethality. Homozygotes for a hypomorphic allele show embryonic growth arrest, altered DNA methylation, and reduced female fertility.
 
Interactions
Kmt2b interacts with 80 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process chromatin modification, gene silencing, ...
Component histone methyltransferase complex, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (107)    Tissues (102)    Images (5)
Theiler Stages: 5, 22, 24, 26, 28
Assay TypeResults
RNA in situ 107
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) cDNA(107) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023938 (Evidence)
Ensembl Gene ModelENSMUSG00000006307 (Evidence)
Entrez Gene75410 (Evidence)
UniGene168688
DFCITC1605268, TC1650796, TC1680651
DoTSDT.111015778, DT.111015787, DT.532544, DT.87035665
NIA Mouse Gene IndexU028390
EC2.1.1.43
Consensus CDS ProjectCCDS21101.1
International Mouse Knockout Project StatusKmt2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023938 VEGA Gene Model | MGI Sequence Detail 19869 C57BL/6J ±  kb
transcript OTTMUST00000058489 VEGA | MGI Sequence Detail 8469 Not Applicable 
polypeptide OTTMUSP00000028343 VEGA | MGI Sequence Detail 2721 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR003889 FY-rich, C-terminal
InterPro IPR003888 FY-rich, N-terminal
InterPro IPR003616 Post-SET domain
InterPro IPR001214 SET domain
InterPro IPR002857 Zinc finger, CXXC-type
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017379 histone-lysine N-methyltransferase MLL4
References (Earliest) J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
(Latest) J:203762 Burton A, et al., Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
All references(48)
Other
accession IDs
MGD-MRK-39564, MGI:1922660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory