About   Help   FAQ
Kmt2b
Gene Detail
Symbol

Name
ID
Kmt2b
lysine (K)-specific methyltransferase 2B
MGI:109565
Synonyms
2610014H22Rik, mKIAA0304, Mll2, Wbp7
Feature Type
protein coding gene
Genetic Map
Chromosome 7
18.63 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:30568858-30588726 bp, - strand
From VEGA annotation of GRCm38

  19869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KMT2B
Gene Tree: Kmt2b

Human
homologs
KMT2B, lysine (K)-specific methyltransferase 2B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9757
neXtProt AC: NX_Q9UMN6

Human Synonyms: CXXC10, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP7, WBP-7

Human Chr (Location): 19q13.1; chr19:35717995-35738880 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this gene leads to embryonic growth retardation, abnormal somite development, neural tube defects, increased apoptosis, and complete embryonic lethality. Homozygotes for a hypomorphic allele show embryonic growth arrest, altered DNA methylation, and reduced female fertility.
 
Interactions
Kmt2b interacts with 80 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process chromatin modification, gene silencing, ...
Component histone methyltransferase complex, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (107)    Tissues (103)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN kmt2bb    NEW 
Molecular
reagents
All nucleic(108) cDNA(107) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000023938 (Evidence)
Ensembl Gene Model ENSMUSG00000006307 (Evidence)
Entrez Gene 75410 (Evidence)
UniGene 168688
DFCI TC1680651, TC1650796, TC1605268
DoTS DT.111015778, DT.87035665, DT.532544, DT.111015787
NIA Mouse Gene Index U028390
EC 2.1.1.43
Consensus CDS Project CCDS21101.1
International Mouse Phenotyping Consortium Status Kmt2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023938 VEGA Gene Model | MGI Sequence Detail 19869 C57BL/6J ±  kb
transcript OTTMUST00000058489 VEGA | MGI Sequence Detail 8469 Not Applicable 
polypeptide OTTMUSP00000028343 VEGA | MGI Sequence Detail 2721 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR003889 FY-rich, C-terminal
InterPro IPR003888 FY-rich, N-terminal
InterPro IPR003616 Post-SET domain
InterPro IPR001214 SET domain
InterPro IPR002857 Zinc finger, CXXC-type
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017379 histone-lysine N-methyltransferase MLL4
References
(Earliest) J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
(Latest) J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14
All references(52)
Other
accession IDs
MGD-MRK-39564, MGI:1922660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory