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Kif5a Gene Detail
Summary
  • Symbol
    Kif5a
  • Name
    kinesin family member 5A
  • Synonyms
    D10Bwg0738e, Khc, Kif5, Kns
  • Feature Type
    protein coding gene
  • IDs
    MGI:109564
    NCBI Gene: 16572
  • Gene Overview
    MyGene.info: KIF5A
Location & Maps
more
  • Sequence Map
    Chr10:127225696-127263363 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37668 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KIF5A, kinesin family member 5A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF5A, kinesin family member 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D12S1889, MY050, NKHC, SPG10
  • Links
    NCBI Gene ID: 3798
    neXtProt AC: NX_Q12840

  • Chr Location
    12q13.3; chr12:57550064-57584771 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF5A associations

Human Disease Mouse Models
       Spastic Paraplegia 10, Autosomal Dominant; SPG10   OMIM: 604187
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes complete neonatal lethality. Homozygotes delivered by caesarian section are alive at E18.5 but usually die within minutes after birth, exhibiting an abnormal breathing pattern, atelectasis, cyanosis, and abnormal motor neuron morphology in the spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074657 Ensembl Gene Model | MGI Sequence Detail 37668 C57BL/6J ±  kb
transcript ENSMUST00000099172 Ensembl | MGI Sequence Detail 6310 Not Applicable  
polypeptide ENSMUSP00000096775 Ensembl | MGI Sequence Detail 1027 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    331 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 106
    cDNA 104
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-11589, MGD-MRK-34087, MGD-MRK-37432, MGD-MRK-39563, MGI:106394
References
more
  • Summaries
    All 64
    Developmental Gene Expression 10
    Gene Ontology 14
    Phenotypes 9
  • Earliest
    J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
  • Latest
    J:229250 Cui J, et al., Analysis of Kif5b expression during mouse kidney development. PLoS One. 2015;10(4):e0126002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory