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Kif5a Gene Detail
Summary
  • Symbol
    Kif5a
  • Name
    kinesin family member 5A
  • Synonyms
    D10Bwg0738e, Khc, Kif5, Kns
  • Feature Type
    protein coding gene
  • IDs
    MGI:109564
    NCBI Gene: 16572
  • Gene Overview
    MyGene.info: KIF5A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127225696-127263348 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109564
protein coding gene Chr10:127225695-127263363 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017813
protein coding gene Chr10:130811877-130850924 (-)
A/J MGP_AJ_G0017788
protein coding gene Chr10:125571164-125608699 (-)
AKR/J MGP_AKRJ_G0017751
protein coding gene Chr10:129285613-129323070 (-)
BALB/cJ MGP_BALBcJ_G0017752
protein coding gene Chr10:125981678-126020154 (-)
C3H/HeJ MGP_C3HHeJ_G0017576
protein coding gene Chr10:129435895-129475038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018207
protein coding gene Chr10:135246820-135287624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015887
protein coding gene Chr10:119577215-119616524 (-)
CAST/EiJ MGP_CASTEiJ_G0017136
protein coding gene Chr10:130090347-130133456 (-)
CBA/J MGP_CBAJ_G0017545
protein coding gene Chr10:140693562-140738447 (-)
DBA/2J MGP_DBA2J_G0017651
protein coding gene Chr10:124663690-124701205 (-)
FVB/NJ MGP_FVBNJ_G0017646
protein coding gene Chr10:123604044-123641552 (-)
LP/J MGP_LPJ_G0017725
protein coding gene Chr10:131382617-131422496 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017674
protein coding gene Chr10:143399378-143441834 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018247
protein coding gene Chr10:129349302-129388637 (-)
PWK/PhJ MGP_PWKPhJ_G0016921
protein coding gene Chr10:124861668-124903396 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016713
protein coding gene Chr10:128388787-128425236 (-)
WSB/EiJ MGP_WSBEiJ_G0017197
protein coding gene Chr10:129578612-129618401 (-)



Homology
more
  • Human Ortholog
    KIF5A, kinesin family member 5A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF5A, kinesin family member 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS25, D12S1889, MY050, NEIMY, NKHC, SPG10
  • Links
    NCBI Gene ID: 3798
    neXtProt AC: NX_Q12840
    UniProt: Q12840

  • Chr Location
    12q13.3; chr12:57550064-57584771 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KIF5A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes complete neonatal lethality. Homozygotes delivered by caesarian section are alive at E18.5 but usually die within minutes after birth, exhibiting an abnormal breathing pattern, atelectasis, cyanosis, and abnormal motor neuron morphology in the spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074657 Ensembl Gene Model | MGI Sequence Detail 37653 C57BL/6J ±  kb
    transcript ENSMUST00000099172 Ensembl | MGI Sequence Detail 6295 Not Applicable  
    polypeptide ENSMUSP00000096775 Ensembl | MGI Sequence Detail 1027 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 106
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11589, MGD-MRK-34087, MGD-MRK-37432, MGD-MRK-39563, MGI:106394
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Gene Ontology 15
      Phenotypes 9
    • Earliest
      J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
    • Latest
      J:256167 Loughner CL, et al., Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4683-4693

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory