Kif5a
Gene Detail

Symbol Name ID

Kif5a kinesin family member 5A MGI:109564

Synonyms

D10Bwg0738e, Khc, Kif5, Kns

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:127225696-127263363 bp, - strand From Ensembl annotation of GRCm38   37668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinesin heavy chain
Gene Tree: Kif5a

Human homologs

Human Homolog		KIF5A, kinesin family member 5A
NCBI Gene ID		3798
neXtProt AC		NX_Q12840
Human Synonyms		D12S1889, MY050, NKHC, SPG10
Human Chr (Location)		12q13.13; chr12:57943847-57978554 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KIF5A

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Homozygotes for a targeted null mutation die at birth. Most mutants for a postnatal conditional knockout allele exhibit fatal seizures around 3 weeks of age, but about 1/4 survive to 3 months or older.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process
Component	axon part, ciliary rootlet, ...
Function	microtubule binding, microtubule motor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (346)    Tissues (151)    Images (61)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	346

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) cDNA(103) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000074657 (Evidence)
Entrez Gene	16572 (Evidence)
UniGene	30355
DFCI	TC1575166, TC1582501, TC1603346
DoTS	DT.101380281, DT.110607534, DT.40140095, DT.531207, DT.94249364
NIA Mouse Gene Index	U032331
Consensus CDS Project	CCDS24233.1
International Mouse Knockout Project Status	Kif5a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000074657	Ensembl Gene Model | MGI Sequence Detail	37668	C57BL/6J
transcript	ENSMUST00000099172	Ensembl | MGI Sequence Detail	6310	Not Applicable
polypeptide	ENSMUSP00000096775	Ensembl | MGI Sequence Detail	1027	Not Applicable

All sequences(32) RefSeq(4)

Polymorphisms

RFLP(1) : SNPs(243 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000009316	kinesin heavy chain isoform 5A

References

(Earliest) J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
(Latest) J:184828 Yap K, et al., Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention. Genes Dev. 2012 Jun 1;26(11):1209-23
All references(56)

Other accession IDs

MGD-MRK-11589, MGD-MRK-34087, MGD-MRK-37432, MGD-MRK-39563, MGI:106394