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Kif5a
Gene Detail
Symbol

Name
ID
Kif5a
kinesin family member 5A
MGI:109564
Synonyms
D10Bwg0738e, Khc, Kif5, Kns
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:127225696-127263363 bp, - strand
From Ensembl annotation of GRCm38

  37668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinesin heavy chain
Gene Tree: Kif5a

Human
homologs
Human Homolog KIF5A, kinesin family member 5A
NCBI Gene ID 3798
neXtProt AC  NX_Q12840
Human Synonyms  D12S1889, MY050, NKHC, SPG10
Human Chr (Location)  12q13.13; chr12:57550064-57584771 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KIF5A
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die at birth. Most mutants for a postnatal conditional knockout allele exhibit fatal seizures around 3 weeks of age, but about 1/4 survive to 3 months or older.
 
Interactions
Kif5a interacts with 371 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ATP catabolic process, axon guidance, ...
Component axon, ciliary rootlet, ...
Function ATPase activity, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (346)    Tissues (151)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 346
cDNA source data(103)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) cDNA(104) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000074657 (Evidence)
Entrez Gene16572 (Evidence)
UniGene30355
DFCITC1575166, TC1582501, TC1603346
DoTSDT.101380281, DT.110607534, DT.40140095, DT.531207, DT.94249364
NIA Mouse Gene IndexU032331
Consensus CDS ProjectCCDS24233.1
International Mouse Knockout Project StatusKif5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074657 Ensembl Gene Model | MGI Sequence Detail 37668 C57BL/6J ±  kb
transcript ENSMUST00000099172 Ensembl | MGI Sequence Detail 6310 Not Applicable 
polypeptide ENSMUSP00000096775 Ensembl | MGI Sequence Detail 1027 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009316 kinesin heavy chain isoform 5A
References
(Earliest) J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
(Latest) J:197666 Nakajima K, et al., Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Neuron. 2012 Dec 6;76(5):945-61
All references(59)
Other
accession IDs
MGD-MRK-11589, MGD-MRK-34087, MGD-MRK-37432, MGD-MRK-39563, MGI:106394

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory