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Sftpd
Gene Detail
Symbol

Name
ID
Sftpd
surfactant associated protein D
MGI:109515
Synonyms
Sftp4, SP-D
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:41172212-41185198 bp, - strand
From NCBI annotation of GRCm38

  12987 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 1 dog; 1 western clawed frog

Gene Tree: Sftpd

Human
homologs
Human Homolog SFTPD, surfactant protein D
NCBI Gene ID 6441
neXtProt AC  NX_P35247
Human Synonyms  COLEC7, PSP-D, SFTP4, SP-D
Human Chr (Location)  10q22.2-q23.1; chr10:79937740-79949105 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit increased pool sizes of alveolar and tissue phosphatidylcholine, accumulation of surfactant lipids, altered phospholipid structure, emphysema, and pulmonary fibrosis and chronic inflammation.
 
Phenotype Images(3)
Interactions
Sftpd interacts with 17 markers (Mir30c-2, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process immune system process, innate immune response, ...
Component collagen trimer, cytoplasm, ...
Function carbohydrate binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (63)    Tissues (6)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 52
Northern blot 5
RT-PCR 2
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(5) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021795 (Evidence)
Entrez Gene20390 (Evidence)
UniGene1321
DFCITC1686464, TC1628501, TC1583625
DoTSDT.487701, DT.101362504, DT.101362505
NIA Mouse Gene IndexU035439
Consensus CDS ProjectCCDS26962.1
International Mouse Knockout Project StatusSftpd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20390 NCBI Gene Model | MGI Sequence Detail 12987 C57BL/6J ±  kb
transcript NM_009160 RefSeq | MGI Sequence Detail 1326 Not Specified 
polypeptide P50404 UniProt | EBI | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR015097 Lung surfactant protein D coiled-coil trimerisation
Protein Ontology PR:000014775 pulmonary surfactant-associated protein D
Graphical View of Protein Domain Structure
References
(Earliest) J:13598 Wevrick R, et al., Mapping of the murine and rat Facc genes and assessment of flexed-tail as a candidate mouse homolog of Fanconi anemia group C. Mamm Genome. 1993;4(8):440-4
(Latest) J:213341 Li W, et al., Pbx1 activates Fgf10 in the mesenchyme of developing lungs. Genesis. 2014 May;52(5):399-407
All references(126)
Other
accession IDs
MGD-MRK-16239, MGD-MRK-39514, MGI:2145671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory