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Gata5 Gene Detail
Summary
  • Symbol
    Gata5
  • Name
    GATA binding protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109497
    NCBI Gene: 14464
Location & Maps
more
  • Sequence Map
    Chr2:180325133-180334699 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9567 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    GATA5, GATA binding protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GATA5, GATA binding protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bB379O24.1, GATAS
  • Links
    NCBI Gene ID: 140628
    neXtProt AC: NX_Q9BWX5

  • Chr Location
    20q13.33; chr20:62463497-62475970 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    7 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene are viable and fertile and appear to be normal. Females, on the other hand, have abnormalities of the external genitalia, most apparently reduced distance between anus and vagina, and experience reduced fertility due to vaginal tract obstructions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016299 VEGA Gene Model | MGI Sequence Detail 9567 C57BL/6J ±  kb
transcript OTTMUST00000039168 VEGA | MGI Sequence Detail 3277 Not Applicable  
polypeptide OTTMUSP00000017494 VEGA | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007860 transcription factor GATA-5
  • InterPro Domains
    IPR008013 GATA-type transcription activator, N-terminal
    IPR016375 Transcription factor GATA-4/5/6
    IPR028372 Transcription factor GATA-5
    IPR000679 Zinc finger, GATA-type
    IPR013088 Zinc finger, NHR/GATA-type
Molecular
Reagents
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  • All nucleic 17
    Genomic 1
    cDNA 11
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-39496
References
more
  • Summaries
    All 65
    Developmental Gene Expression 34
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:38927 Morrisey EE, et al., GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol. 1997 Mar 1;183(1):21-36
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory