About   Help   FAQ
Gata5
Gene Detail
 Symbol
Name
ID
Gata5
GATA binding protein 5
MGI:109497
Feature Type protein coding gene
Genetic Map
Chromosome 2
102.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:180325133-180334699 bp, - strand
From VEGA annotation of GRCm38

  9567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata5

Human
homologs
Human Homolog GATA5, GATA binding protein 5
NCBI Gene ID 140628
neXtProt AC  NX_Q9BWX5
Human Synonyms  bB379O24.1, GATAS
Human Chr (Location)  20q13.33; chr20:62463497-62475970 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for disruptions in this gene are viable and fertile and appear to be normal. Females, on the other hand, have abnormalities of the external genitalia, most apparently reduced distance between anus and vagina, and experience reduced fertility due to vaginal tract obstructions.
 
Phenotype Images(7)
Interactions
Gata5 interacts with 182 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to BMP stimulus, intestinal epithelial cell differentiation, ...
Component nucleus
Function DNA binding, enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (61)    Tissues (13)    Images (8)
Theiler Stages: 2, 3, 12, 14, 15, 16, 17, 20, 23
Assay TypeResults
Immunohistochemistry 4
RNA in situ 11
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(11) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016299 (Evidence)
Ensembl Gene ModelENSMUSG00000015627 (Evidence)
Entrez Gene14464 (Evidence)
UniGene388880
DFCITC1589643
DoTSDT.55179316, DT.94230075
NIA Mouse Gene IndexU023762
Consensus CDS ProjectCCDS17175.1
International Mouse Knockout Project StatusGata5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016299 VEGA Gene Model | MGI Sequence Detail 9567 C57BL/6J ±  kb
transcript OTTMUST00000039168 VEGA | MGI Sequence Detail 3277 Not Applicable 
polypeptide OTTMUSP00000017494 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008013 GATA-type transcription activator, N-terminal
InterPro IPR016375 Transcription factor GATA-4/5/6
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007860 transcription factor GATA-5
References (Earliest) J:38927 Morrisey EE, et al., GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol. 1997 Mar 1;183(1):21-36
(Latest) J:187204 Thomas PS, et al., Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539
All references(64)
Other
accession IDs
MGD-MRK-39496

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory