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Gata5 Gene Detail
Summary
  • Symbol
    Gata5
  • Name
    GATA binding protein 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109497
    NCBI Gene: 14464
  • Gene Overview
    MyGene.info: GATA5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180325133-180334699 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 102.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109497
protein coding gene Chr2:180325088-180335508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026993
protein coding gene Chr2:186841151-186850715 (-)
A/J MGP_AJ_G0026959
protein coding gene Chr2:179165604-179175167 (-)
AKR/J MGP_AKRJ_G0026929
protein coding gene Chr2:184538549-184548112 (-)
BALB/cJ MGP_BALBcJ_G0026968
protein coding gene Chr2:179629950-179639514 (-)
C3H/HeJ MGP_C3HHeJ_G0026709
protein coding gene Chr2:184877935-184887499 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027414
protein coding gene Chr2:192233705-192243271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024779
protein coding gene Chr2:169854570-169865787 (-)
CAST/EiJ MGP_CASTEiJ_G0026168
protein coding gene Chr2:183127787-183137355 (-)
CBA/J MGP_CBAJ_G0026686
protein coding gene Chr2:199237234-199246798 (-)
DBA/2J MGP_DBA2J_G0026824
protein coding gene Chr2:178263937-178273503 (-)
FVB/NJ MGP_FVBNJ_G0026790
protein coding gene Chr2:176871629-176881203 (-)
LP/J MGP_LPJ_G0026925
protein coding gene Chr2:186847080-186856691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026809
protein coding gene Chr2:201843387-201852951 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027473
protein coding gene Chr2:184493632-184503196 (-)
PWK/PhJ MGP_PWKPhJ_G0025904
protein coding gene Chr2:175773549-175783290 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025704
protein coding gene Chr2:180987594-180997173 (-)
WSB/EiJ MGP_WSBEiJ_G0026240
protein coding gene Chr2:185475265-185484828 (-)



Homology
more
  • Human Ortholog
    GATA5, GATA binding protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GATA5, GATA binding protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bB379O24.1, CHTD5, GATAS
  • Links
    NCBI Gene ID: 140628
    neXtProt AC: NX_Q9BWX5
    UniProt: Q9BWX5

  • Chr Location
    20q13.33; chr20:62463497-62475970 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gata5 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 4 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    7 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene are viable and fertile and appear to be normal. Females, on the other hand, have abnormalities of the external genitalia, most apparently reduced distance between anus and vagina, and experience reduced fertility due to vaginal tract obstructions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015627 Ensembl Gene Model | MGI Sequence Detail 9567 C57BL/6J ±  kb
    transcript ENSMUST00000015771 Ensembl | MGI Sequence Detail 3277 Not Applicable  
    polypeptide ENSMUSP00000015771 Ensembl | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 12
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39496
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 13
      Phenotypes 8
    • Earliest
      J:38927 Morrisey EE, et al., GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol. 1997 Mar 1;183(1):21-36
    • Latest
      J:257920 Tahara N, et al., Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules. Dev Biol. 2018 Feb 1;434(1):74-83

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory