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Esr2 Gene Detail
Summary
  • Symbol
    Esr2
  • Name
    estrogen receptor 2 (beta)
  • Synonyms
    ERbeta, ER beta, Estrb, oestrogen receptor beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109392
    NCBI Gene: 13983
  • Gene Overview
    MyGene.info: ESR2
Location & Maps
more
  • Sequence Map
    Chr12:76120419-76177259 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56841 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 33.52 cM, cytoband D1-D3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ESR2, estrogen receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ESR2, estrogen receptor 2
    Orthology source: HomoloGene
  • Synonyms
    Erb, ER-BETA, ESRB, ESR-BETA, ESTRB, NR3A2
  • Links
    NCBI Gene ID: 2100
    neXtProt AC: NX_Q92731

  • Chr Location
    14q23.2; chr14:64172925-64338550 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1100
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ESR2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    138 phenotypes from 6 alleles in 9 genetic backgrounds
    68 phenotypes from multigenic genotypes
    213 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Targeted
    14
  • Genomic Mutations
    1 involving Esr2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neural, behavior, glucose homeostasis, sex-specific nociception, cardiac, and ion channel abnormalities and myeloproliferative disorders. Females are sterile/subfertile with granulosa cell defects; males show prostate hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021138 VEGA Gene Model | MGI Sequence Detail 56841 C57BL/6J ±  kb
transcript OTTMUST00000050081 VEGA | MGI Sequence Detail 3362 Not Applicable  
polypeptide OTTMUSP00000023324 VEGA | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    624 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR028355 Estrogen receptor beta/gamma
    IPR021064 Estrogen receptor beta, N-terminal
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR024178 Oestrogen receptor/oestrogen-related receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 19
    cDNA 13
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38437
References
more
  • Summaries
    All 322
    Developmental Gene Expression 27
    Gene Ontology 18
    Phenotypes 213
  • Earliest
    J:38785 Tremblay GB, et al., Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol. 1997 Mar;11(3):353-65
  • Latest
    J:231635 Nalvarte I, et al., Estrogen receptor beta controls MMP-19 expression in mouse ovaries during ovulation. Reproduction. 2016 Mar;151(3):253-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory