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Esr2
Gene Detail
 Symbol
Name
ID
Esr2
estrogen receptor 2 (beta)
MGI:109392
Synonyms ERbeta, ER beta, Estrb, oestrogen receptor beta
Feature Type protein coding gene
Genetic Map
Chromosome 12
33.52 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:76120419-76177259 bp, - strand
From VEGA annotation of GRCm38

  56841 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esr2

Human
homologs
Human Homolog ESR2, estrogen receptor 2 (ER beta)
NCBI Gene ID 2100
neXtProt AC  NX_Q92731
Human Synonyms  Erb, ER-BETA, ESRB, ESR-BETA, ESTRB, NR3A2
Human Chr (Location)  14q23.2; chr14:64184009-64338580 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Targeted(11)
 
Mice homozygous for a knock-out allele exhibit neural, behavior, glucose homeostasis, sex-specific nociception, cardiac, and ion channel abnormalities and myeloproliferative disorders. Females are sterile/subfertile with granulosa cell defects; males show prostate hyperplasia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process behavioral fear response, brain development, ...
Component cytoplasm, mitochondrion, ...
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (171)    Tissues (97)    Images (19)
Theiler Stages: 2, 3, 4, 5, 11, 13, 16, 17, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 92
RT-PCR 79
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) cDNA(13) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021138 (Evidence)
Ensembl Gene ModelENSMUSG00000021055 (Evidence)
Entrez Gene13983 (Evidence)
UniGene2561
DFCITC1586060, TC1595723
DoTSDT.110930602, DT.87035439, DT.97385262
NIA Mouse Gene IndexU034084
Consensus CDS ProjectCCDS25987.1, CCDS25988.1
International Mouse Knockout Project StatusEsr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021138 VEGA Gene Model | MGI Sequence Detail 56841 C57BL/6J ±  kb
transcript OTTMUST00000050081 VEGA | MGI Sequence Detail 3362 Not Applicable 
polypeptide OTTMUSP00000023324 VEGA | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(5) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(677 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021064 Estrogen receptor beta, N-terminal
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007205 estrogen receptor beta
References (Earliest) J:38785 Tremblay GB, et al., Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol. 1997 Mar;11(3):353-65
(Latest) J:206524 Hsu I, et al., Suppression of ERbeta signaling via ERbeta knockout or antagonist protects against bladder cancer development. Carcinogenesis. 2014 Mar;35(3):651-61
All references(288)
Other
accession IDs
MGD-MRK-38437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory