Esr2
Gene Detail

Symbol Name ID

Esr2 estrogen receptor 2 (beta) MGI:109392

Synonyms

ERbeta, ER beta, Estrb, oestrogen receptor beta

Feature Type

protein coding gene

Genetic Map

Chromosome 12

33.52 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:76120419-76177259 bp, - strand From VEGA annotation of GRCm38   56841 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esr2

Human homologs

Human Homolog		ESR2, estrogen receptor 2 (ER beta)
NCBI Gene ID		2100
neXtProt AC		NX_Q92731
Human Synonyms		Erb, ER-BETA, ESRB, ESR-BETA, ESTRB, NR3A2
Human Chr (Location)		14q23.2; chr14:64693751-64805268 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Mice homozygous for a knock-out allele exhibit neural, behavior, glucose homeostasis, sex-specific nociception, cardiac, and ion channel abnormalities and myeloproliferative disorders. Females are sterile/subfertile with granulosa cell defects; males show prostate hyperplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	behavioral fear response, brain development, ...
Component	cytoplasm, mitochondrion, ...
Function	core promoter sequence-specific DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (171)    Tissues (97)    Images (19)
Theiler Stages: 2, 3, 4, 5, 11, 13, 16, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	92
RT-PCR	79

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(13) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021138 (Evidence)
Ensembl Gene Model	ENSMUSG00000021055 (Evidence)
Entrez Gene	13983 (Evidence)
UniGene	2561
DFCI	TC1586060, TC1595723
DoTS	DT.110930602, DT.87035439, DT.97385262
NIA Mouse Gene Index	U034084
Consensus CDS Project	CCDS25987.1, CCDS25988.1
International Mouse Knockout Project Status	Esr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021138	VEGA Gene Model | MGI Sequence Detail	56841	C57BL/6J
transcript	OTTMUST00000050081	VEGA | MGI Sequence Detail	3362	Not Applicable
polypeptide	OTTMUSP00000023324	VEGA | MGI Sequence Detail	567	Not Applicable

All sequences(36) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(546 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021064	Estrogen receptor beta, N-terminal
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR024178	Oestrogen receptor-related nuclear receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000007205	estrogen receptor beta

References

(Earliest) J:38785 Tremblay GB, et al., Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol. 1997 Mar;11(3):353-65
(Latest) J:192996 Paramanik V, et al., Estrogen receptor beta and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain. J Biol Chem. 2012 Jun 22;287(26):22305-16
All references(278)

Other accession IDs

MGD-MRK-38437