About   Help   FAQ
Etv6
Gene Detail
Symbol

Name
ID
Etv6
ets variant 6
MGI:109336
Synonyms
Tel, translocation-ets-leukemia
Feature Type
protein coding gene
Genetic Map
Chromosome 6
64.58 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:134035700-134270158 bp, + strand
From VEGA annotation of GRCm38

  234459 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ETV6
Gene Tree: Etv6

Human
homologs
ETV6, ets variant 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2120
neXtProt AC: NX_P41212

Human Synonyms: TEL, TEL/ABL, THC5

Human Chr (Location): 12p13; chr12:11649854-11895402 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ETV6

Mutations,
alleles, and
phenotypes
All mutations/alleles(135) : Gene trapped(127) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defective yolk sac angiogenesis, excess apoptosis of mesenchymal and neural cells, and midgestational lethality.
 
Interactions
Etv6 interacts with 363 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, hematopoietic stem cell proliferation, ...
Component cytoplasm, nucleolus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (294)    Tissues (245)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 278
RT-PCR 16
cDNA source data(150)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase etv6 ; ZFIN etv6    NEW 
Molecular
reagents
All nucleic(157) Genomic(1) cDNA(153) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025993 (Evidence)
Ensembl Gene Model ENSMUSG00000030199 (Evidence)
Entrez Gene 14011 (Evidence)
UniGene 269995
DoTS DT.110493502, DT.110493580, DT.40181926, DT.535237, DT.99841130
NIA Mouse Gene Index U042770
PDB 2LF7, 2LF8, 2MD5, 4MHG
Consensus CDS Project CCDS39677.1
International Mouse Phenotyping Consortium Status Etv6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025993 VEGA Gene Model | MGI Sequence Detail 234459 C57BL/6J ±  kb
transcript OTTMUST00000064123 VEGA | MGI Sequence Detail 5548 Not Applicable 
polypeptide OTTMUSP00000031804 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(2739 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2743)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007229 transcription factor ETV6
References
(Earliest) J:38299 Depatie C, et al., High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 1997 Jan 15;39(2):154-63
(Latest) J:179397 Schachterle W, et al., ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49
All references(67)
Other
accession IDs
MGD-MRK-38381, MGI:2141650, MGI:2141710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory