Etv6
Gene Detail

Symbol

Name
ID

Etv6
ets variant 6
MGI:109336

Synonyms

Tel, translocation-ets-leukemia

Feature Type

protein coding gene

Genetic Map

Chromosome 6
64.58 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr6:134035700-134270158 bp, + strand From VEGA annotation of GRCm38   234459 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Etv6

Human
homologs

Human Homolog		ETV6, ets variant 6
NCBI Gene ID		2120
neXtProt AC		NX_P41212
Human Synonyms		TEL, TEL/ABL, THC5
Human Chr (Location)		12p13; chr12:11649854-11895402 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human ETV6

Mutations,
alleles, and
phenotypes

All mutations/alleles(135) : Gene trapped(127) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation exhibit defective yolk sac angiogenesis, excess apoptosis of mesenchymal and neural cells, and midgestational lethality.

 

Interactions

Etv6 interacts with 364 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleolus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)

Data Summary: Results (294)    Tissues (245)    Images (55)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	278
RT-PCR	16

cDNA source data(150)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(157) Genomic(1) cDNA(153) Primer pair(3)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000025993 (Evidence)
Ensembl Gene Model	ENSMUSG00000030199 (Evidence)
Entrez Gene	14011 (Evidence)
UniGene	269995
DoTS	DT.535237, DT.99841130, DT.40181926, DT.110493580, DT.110493502
NIA Mouse Gene Index	U042770
PDB	4MHG, 2LF7, 2LF8, 2MD5
Consensus CDS Project	CCDS39677.1
International Mouse Knockout Project Status	Etv6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025993	VEGA Gene Model | MGI Sequence Detail	234459	C57BL/6J
transcript	OTTMUST00000064123	VEGA | MGI Sequence Detail	5548	Not Applicable
polypeptide	OTTMUSP00000031804	VEGA | MGI Sequence Detail	485	Not Applicable

All sequences(61) RefSeq(10) UniProt(9)

Polymorphisms

RFLP(1) : SNPs within 2kb(2739 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2743)

Protein-related
information

Resource	ID	Description
InterPro	IPR000418	Ets domain
InterPro	IPR003118	Pointed domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007229	transcription factor ETV6

References

(Earliest) J:38299 Depatie C, et al., High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 1997 Jan 15;39(2):154-63
(Latest) J:179397 Schachterle W, et al., ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49
All references(69)

Other
accession IDs

MGD-MRK-38381, MGI:2141650, MGI:2141710