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F7 Gene Detail
Summary
  • Symbol
    F7
  • Name
    coagulation factor VII
  • Synonyms
    Cf7, FVII
  • Feature Type
    protein coding gene
  • IDs
    MGI:109325
    NCBI Gene: 14068
  • Gene Overview
    MyGene.info: F7
Location & Maps
more
  • Sequence Map
    Chr8:13026034-13035809 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9776 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    F7, coagulation factor VII
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F7, coagulation factor VII
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPCA
  • Links
    NCBI Gene ID: 2155
    neXtProt AC: NX_P08709

  • Chr Location
    13q34; chr13:113105788-113120681 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with F7 mouse models; 2 with human F7 associations

Human Disease Mouse Models
       Factor VII Deficiency   OMIM: 227500 View 1 model
       Myocardial Infarction, Susceptibility to   OMIM: 608446
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Spontaneous
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020609 VEGA Gene Model | MGI Sequence Detail 9776 C57BL/6J ±  kb
transcript OTTMUST00000048835 VEGA | MGI Sequence Detail 1859 Not Applicable  
polypeptide OTTMUSP00000022498 VEGA | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    228 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007301 coagulation factor VII
  • EC
  • InterPro Domains
    IPR017857 Coagulation factor, subgroup, Gla domain
    IPR033190 Coagulation factor VII
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 32
    Genomic 8
    cDNA 22
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38370, MGI:2142467
References
more
  • Summaries
    All 52
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:32983 Idusogie E, et al., Characterization of a cDNA encoding murine coagulation factor VII. Thromb Haemost. 1996 Mar;75(3):481-7
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory