About   Help   FAQ
F7 Gene Detail
Summary
  • Symbol
    F7
  • Name
    coagulation factor VII
  • Synonyms
    Cf7, FVII
  • Feature Type
    protein coding gene
  • IDs
    MGI:109325
    NCBI Gene: 14068
  • Gene Overview
    MyGene.info: F7
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13026034-13035809 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109325
protein coding gene Chr8:13025506-13035809 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033368
protein coding gene Chr8:10338596-10348352 (+)
A/J MGP_AJ_G0033348
protein coding gene Chr8:9971473-9981248 (+)
AKR/J MGP_AKRJ_G0033279
protein coding gene Chr8:10236925-10246700 (+)
BALB/cJ MGP_BALBcJ_G0033349
protein coding gene Chr8:10111873-10121644 (+)
C3H/HeJ MGP_C3HHeJ_G0033062
protein coding gene Chr8:10448654-10458429 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033861
protein coding gene Chr8:10705527-10715302 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030830
protein coding gene Chr8:9478685-9488434 (+)
CAST/EiJ MGP_CASTEiJ_G0032384
protein coding gene Chr8:10210312-10219951 (+)
CBA/J MGP_CBAJ_G0033035
protein coding gene Chr8:11156410-11166185 (+)
DBA/2J MGP_DBA2J_G0033188
protein coding gene Chr8:9930301-9940076 (+)
FVB/NJ MGP_FVBNJ_G0033137
protein coding gene Chr8:9935107-9944882 (+)
LP/J MGP_LPJ_G0033282
protein coding gene Chr8:10261582-10271450 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033171
protein coding gene Chr8:11413087-11422862 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033878
protein coding gene Chr8:10300978-10310734 (+)
PWK/PhJ MGP_PWKPhJ_G0032097
protein coding gene Chr8:9974993-9984872 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031939
protein coding gene Chr8:10189716-10199261 (+)
WSB/EiJ MGP_WSBEiJ_G0032500
protein coding gene Chr8:10335885-10345605 (+)



Homology
more
  • Human Ortholog
    F7, coagulation factor VII
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F7, coagulation factor VII
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPCA
  • Links
    NCBI Gene ID: 2155
    neXtProt AC: NX_P08709
    UniProt: P08709

  • Chr Location
    13q34; chr13:113105773-113120681 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human F7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031443 Ensembl Gene Model | MGI Sequence Detail 9776 C57BL/6J ±  kb
    transcript ENSMUST00000033820 Ensembl | MGI Sequence Detail 1859 Not Applicable  
    polypeptide ENSMUSP00000033820 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 8
      cDNA 23
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38370, MGI:2142467
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:32983 Idusogie E, et al., Characterization of a cDNA encoding murine coagulation factor VII. Thromb Haemost. 1996 Mar;75(3):481-7
    • Latest
      J:262230 Lacombe J, et al., VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. JCI Insight. 2018 Jan 11;3(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory