F7
Gene Detail

Symbol Name ID

F7 coagulation factor VII MGI:109325

Synonyms

Cf7, FVII

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:13026034-13035809 bp, + strand From VEGA annotation of GRCm38   9776 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7710  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F7

Human homologs

Human Homolog		F7, coagulation factor VII (serum prothrombin conversion accelerator)
NCBI Gene ID		2155
neXtProt AC		NX_P08709
Human Synonyms		SPCA
Human Chr (Location)		13q34; chr13:113760102-113774995 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human F7

Alleles and phenotypes

All alleles(5) : Targeted(4) Spontaneous(1)
 

Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, extracellular space, ...
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (55)    Tissues (53)    Images (1)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RT-PCR	55

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(8) cDNA(22) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020609 (Evidence)
Ensembl Gene Model	ENSMUSG00000031443 (Evidence)
Entrez Gene	14068 (Evidence)
UniGene	4827
DFCI	TC1584795
DoTS	DT.527478
NIA Mouse Gene Index	U009097
EC	3.4.21.21
Consensus CDS Project	CCDS22104.1
International Mouse Knockout Project Status	F7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020609	VEGA Gene Model | MGI Sequence Detail	9776	C57BL/6J
transcript	OTTMUST00000048835	VEGA | MGI Sequence Detail	1859	Not Applicable
polypeptide	OTTMUSP00000022498	VEGA | MGI Sequence Detail	446	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000007301	coagulation factor VII

References

(Earliest) J:32983 Idusogie E, et al., Characterization of a cDNA encoding murine coagulation factor VII. Thromb Haemost. 1996 Mar;75(3):481-7
(Latest) J:181747 Binny C, et al., AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood. 2012 Jan 26;119(4):957-66
All references(52)

Other accession IDs

MGD-MRK-38370, MGI:2142467