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F7
Gene Detail
 Symbol
Name
ID
F7
coagulation factor VII
MGI:109325
Synonyms Cf7, FVII
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:13026034-13035809 bp, + strand
From VEGA annotation of GRCm38

  9776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7710  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F7

Human
homologs
Human Homolog F7, coagulation factor VII (serum prothrombin conversion accelerator)
NCBI Gene ID 2155
neXtProt AC  NX_P08709
Human Synonyms  SPCA
Human Chr (Location)  13q34; chr13:113105788-113120681 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human F7
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.
 
Phenotype Images(2)
Interactions
F7 interacts with 57 markers (Mir17, Mir18b, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (55)    Tissues (53)    Images (1)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RT-PCR 55
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(8) cDNA(22) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020609 (Evidence)
Ensembl Gene ModelENSMUSG00000031443 (Evidence)
Entrez Gene14068 (Evidence)
UniGene4827
DFCITC1584795
DoTSDT.527478
NIA Mouse Gene IndexU009097
EC3.4.21.21
Consensus CDS ProjectCCDS22104.1
International Mouse Knockout Project StatusF7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020609 VEGA Gene Model | MGI Sequence Detail 9776 C57BL/6J ±  kb
transcript OTTMUST00000048835 VEGA | MGI Sequence Detail 1859 Not Applicable 
polypeptide OTTMUSP00000022498 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007301 coagulation factor VII
References (Earliest) J:32983 Idusogie E, et al., Characterization of a cDNA encoding murine coagulation factor VII. Thromb Haemost. 1996 Mar;75(3):481-7
(Latest) J:203644 Funnell AP, et al., A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. Am J Hum Genet. 2013 Mar 7;92(3):460-7
All references(54)
Other
accession IDs
MGD-MRK-38370, MGI:2142467

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory