F7 MGI Mouse Gene Detail - MGI:109325 - coagulation factor VII

Symbol

F7
Name

coagulation factor VII
Synonyms

Cf7, FVII

Feature Type

protein coding gene
IDs

MGI:109325
NCBI Gene: 14068
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:13076034-13085809 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

3 experiments

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109325	protein coding gene	Chr8:13075499-13085809 (+)
129S1/SvImJ	ENSMUSG00200010835	protein coding gene	Chr8:9970160-9979916 (+)
A/J	ENSMUSG00195042229	protein coding gene	Chr8:10319106-10328884 (+)
AKR/J	ENSMUSG00220030797	protein coding gene	Chr8:10048362-10058139 (+)
BALB/cJ	ENSMUSG00180004179	protein coding gene	Chr8:9958192-9967967 (+)
C3H/HeJ	ENSMUSG00175037181	protein coding gene	Chr8:10118030-10127807 (+)
C57BL/6NJ	ENSMUSG00215007440	protein coding gene	Chr8:9992387-10002162 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030830	protein coding gene	Chr8:9478685-9488434 (+)
CAST/EiJ	ENSTCUG00005020339	protein coding gene	Chr8:9968257-9977901 (+)
CBA/J	ENSMUSG00210010400	protein coding gene	Chr8:9951886-9961661 (+)
DBA/2J	ENSMUSG00185006449	protein coding gene	Chr8:10084635-10094410 (+)
FVB/NJ	ENSMUSG00205005565	protein coding gene	Chr8:9977346-9987121 (+)
JF1/MsJ	ENSUMUG00000018463	protein coding gene	Chr8:10107367-10117115 (+)
LP/J	ENSMUSG00230018589	protein coding gene	Chr8:12265993-12275741 (+)
NOD/ShiLtJ	ENSMUSG00190029649	protein coding gene	Chr8:10076742-10086517 (+)
NZO/HlLtJ	ENSMUSG00225041970	protein coding gene	Chr8:20130133-20139889 (+)
PWK/PhJ	ENSLUMG00010027161	protein coding gene	Chr8:10034442-10044205 (+)
SPRET/EiJ	ENSMSPG00010012635	protein coding gene	Chr8:10144378-10153935 (+)
WSB/EiJ	ENSIUOG00005004215	protein coding gene	Chr8:9983859-9993581 (+)

Human Ortholog

F7, coagulation factor VII

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F7, coagulation factor VII
Synonyms

SPCA
Links

HGNC:3544

NCBI Gene ID: 2155

UniProt: P08709
Chr Location

13q34; chr13:113105762-113120685 (+) GRCh38

MGI Vertebrate Homology

F7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: F7
Protein SuperFamily

Factor_X
Gene Tree

F7

Diseases

11 with human F7 associations

				Human Disease	Mouse Models
				acute pancreatitis IDs acute pancreatitis DOID:2913 DOID:2912 ICD10CM:K85 ICD9CM:577.0 MESH:D010195 NCI:C95437 UMLS_CUI:C0001339
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				factor VII deficiency IDs factor VII deficiency DOID:2215 ICD10CM:D68.2 MESH:D005168 NCI:C131631 OMIM:227500 ORDO:327 UMLS_CUI:C0015503
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				thrombocytopenia IDs thrombocytopenia DOID:1588 ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 NCI:C203448 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 UMLS_CUI:C0040034
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 3 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
2 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Spontaneous

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.

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All GO Annotations

66
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

665
Tissues

59
cDNA Data

23
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f7

ZFIN f7

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All Sequences

40
RefSeq

3
UniProt

3
CCDS

CCDS22104.1

Ensembl

ENSMUSG00000031443 (Evidence)
NCBI Gene

14068

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031443	Ensembl Gene Model \| MGI Sequence Detail	9776	C57BL/6J	± kb
transcript	ENSMUST00000033820	Ensembl \| MGI Sequence Detail	1859	Not Applicable
polypeptide	ENSMUSP00000033820	Ensembl \| MGI Sequence Detail	446	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007301 coagulation factor VII

(term hierarchy)
PDB

5KXH, 5KY2, 5KY3
EC

3.4.21.1, 3.4.21.21
InterPro Domains

IPR017857 Coagulation factor-like, Gla domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain

IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

IPR001314 Peptidase S1A, chymotrypsin family

IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

IPR050442 Peptidase S1 family, coagulation factors

IPR009003 Peptidase S1, PA clan

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR001254 Serine proteases, trypsin domain

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

P70375 3 sites

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All nucleic 35

Genomic 8

cDNA 23

Primer pair 4

Microarray probesets 3

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MGD-MRK-38370, MGI:2142467

Summaries

All 71

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 25
Earliest

J:32983 Idusogie E, et al., Characterization of a cDNA encoding murine coagulation factor VII. Thromb Haemost. 1996 Mar;75(3):481-7
Latest

J:379142 Molina JJ, et al., Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Nat Commun. 2024 Mar 27;15(1):2704

TSS for F7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76323	Chr8:13076024-13076056 (+)	6 bp
Tssr76324	Chr8:13081929-13081950 (+)	5,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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