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Fadd
Gene Detail
Symbol

Name
ID
Fadd
Fas (TNFRSF6)-associated via death domain
MGI:109324
Synonyms
Mort1/FADD
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:144577318-144582463 bp, - strand
From VEGA annotation of GRCm38

  5146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FADD
Protein SuperFamily: FADD protein
Gene Tree: Fadd

Human
homologs
FADD, Fas (TNFRSF6)-associated via death domain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8772
neXtProt AC: NX_Q13158

Human Synonyms: GIG3, MORT1

Human Chr (Location): 11q13.3; chr11:70203163-70207402 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FADD

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(9) Transgenic(1)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis.
 
Interactions
Fadd interacts with 323 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (75)    Tissues (63)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 1
RT-PCR 50
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fadd ; ZFIN fadd    NEW 
Molecular
reagents
All nucleic(43) Genomic(7) cDNA(34) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033373 (Evidence)
Ensembl Gene Model ENSMUSG00000031077 (Evidence)
Entrez Gene 14082 (Evidence)
UniGene 5126
DFCI TC1578092, TC1596939
DoTS DT.527039
NIA Mouse Gene Index U029526
PDB 1FAD
Consensus CDS Project CCDS22050.1
International Mouse Phenotyping Consortium Status Fadd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033373 VEGA Gene Model | MGI Sequence Detail 5146 C57BL/6J ±  kb
transcript OTTMUST00000083781 VEGA | MGI Sequence Detail 3903 Not Applicable 
polypeptide OTTMUSP00000045061 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
InterPro IPR016729 FADD
Protein Ontology PR:000002189 FADD protein
References
(Earliest) J:113685 Boldin MP, et al., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995 Apr 7;270(14):7795-8
(Latest) J:223015 Kang S, et al., Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015;6:7515
All references(99)
Other
accession IDs
MGD-MRK-38369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory