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Fadd Gene Detail
Summary
  • Symbol
    Fadd
  • Name
    Fas (TNFRSF6)-associated via death domain
  • Synonyms
    Mort1/FADD
  • Feature Type
    protein coding gene
  • IDs
    MGI:109324
    NCBI Gene: 14082
  • Gene Overview
    MyGene.info: FADD
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144578323-144582436 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109324
protein coding gene Chr7:144577318-144582463 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033289
protein coding gene Chr7:149940605-149947458 (-)
A/J MGP_AJ_G0033272
protein coding gene Chr7:145584702-145589834 (-)
AKR/J MGP_AKRJ_G0033203
protein coding gene Chr7:149686273-149693441 (-)
BALB/cJ MGP_BALBcJ_G0033272
protein coding gene Chr7:145367428-145372561 (-)
C3H/HeJ MGP_C3HHeJ_G0032986
protein coding gene Chr7:149450590-149456203 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033782
protein coding gene Chr7:155358393-155363530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030755
protein coding gene Chr7:146746496-146751537 (-)
CAST/EiJ MGP_CASTEiJ_G0032309
protein coding gene Chr7:141758889-141763834 (-)
CBA/J MGP_CBAJ_G0032959
protein coding gene Chr7:160649993-160655751 (-)
DBA/2J MGP_DBA2J_G0033113
protein coding gene Chr7:143565185-143570294 (-)
FVB/NJ MGP_FVBNJ_G0033061
protein coding gene Chr7:143502373-143507498 (-)
LP/J MGP_LPJ_G0033205
protein coding gene Chr7:151470150-151475333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033095
protein coding gene Chr7:161188684-161194721 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033800
protein coding gene Chr7:148656608-148661778 (-)
PWK/PhJ MGP_PWKPhJ_G0032019
protein coding gene Chr7:136871323-136876451 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031863
protein coding gene Chr7:135437157-135442222 (-)
WSB/EiJ MGP_WSBEiJ_G0032422
protein coding gene Chr7:149644049-149649249 (-)



Homology
more
  • Human Ortholog
    FADD, Fas associated via death domain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FADD, Fas associated via death domain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIG3, MORT1
  • Links
    NCBI Gene ID: 8772
    neXtProt AC: NX_Q13158
    UniProt: Q13158

  • Chr Location
    11q13.3; chr11:70203163-70207402 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 7 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14082 NCBI Gene Model | MGI Sequence Detail 4114 C57BL/6J ±  kb
    transcript NM_010175 RefSeq | MGI Sequence Detail 2876 C57BL/6  
    polypeptide Q61160 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 7
      cDNA 35
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38369
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 12
      Gene Ontology 25
      Phenotypes 55
    • Earliest
      J:113685 Boldin MP, et al., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995 Apr 7;270(14):7795-8
    • Latest
      J:263687 Wang CX, et al., METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol. 2018 Jun;16(6):e2004880

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory