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Fadd
Gene Detail
 Symbol
Name
ID
Fadd
Fas (TNFRSF6)-associated via death domain
MGI:109324
Synonyms Mort1/FADD
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:144577318-144582463 bp, - strand
From VEGA annotation of GRCm38

  5146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: FADD protein
Gene Tree: Fadd

Human
homologs
Human Homolog FADD, Fas (TNFRSF6)-associated via death domain
NCBI Gene ID 8772
neXtProt AC  NX_Q13158
Human Synonyms  MORT1
Human Chr (Location)  11q13.3; chr11:70203163-70207402 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FADD
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process activation of cysteine-type endopeptidase activity, apoptotic process, ...
Component CD95 death-inducing signaling complex, cell body, ...
Function death effector domain binding, death receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (75)    Tissues (62)    Images (3)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 24
Western blot 1
RT-PCR 50
cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) Genomic(7) cDNA(34) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033373 (Evidence)
Ensembl Gene ModelENSMUSG00000031077 (Evidence)
Entrez Gene14082 (Evidence)
UniGene5126
DFCITC1578092, TC1596939
DoTSDT.527039
NIA Mouse Gene IndexU029526
PDB1FAD
Consensus CDS ProjectCCDS22050.1
International Mouse Knockout Project StatusFadd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033373 VEGA Gene Model | MGI Sequence Detail 5146 C57BL/6J ±  kb
transcript OTTMUST00000083781 VEGA | MGI Sequence Detail 3903 Not Applicable 
polypeptide OTTMUSP00000045061 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR001875 Death effector domain
InterPro IPR011029 Death-like domain
InterPro IPR016729 FADD
Protein Ontology PR:000002189 FADD protein
References (Earliest) J:113685 Boldin MP, et al., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995 Apr 7;270(14):7795-8
(Latest) J:206043 Fan Q, et al., Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model. PLoS One. 2013;8(9):e73537
All references(89)
Other
accession IDs
MGD-MRK-38369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory