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Fadd Gene Detail
Summary
  • Symbol
    Fadd
  • Name
    Fas (TNFRSF6)-associated via death domain
  • Synonyms
    Mort1/FADD
  • Feature Type
    protein coding gene
  • IDs
    MGI:109324
    NCBI Gene: 14082
  • Gene Overview
    MyGene.info: FADD
Location & Maps
more
  • Sequence Map
    Chr7:144577318-144582463 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5146 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FADD, Fas associated via death domain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FADD, Fas associated via death domain
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GIG3, MORT1
  • Links
    NCBI Gene ID: 8772
    neXtProt AC: NX_Q13158

  • Chr Location
    11q13.3; chr11:70203163-70207402 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FADD associations

Human Disease Mouse Models
       Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations   OMIM: 613759
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 7 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    9
  • Transgenic
    3
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033373 VEGA Gene Model | MGI Sequence Detail 5146 C57BL/6J ±  kb
transcript OTTMUST00000083781 VEGA | MGI Sequence Detail 3903 Not Applicable  
polypeptide OTTMUSP00000045061 VEGA | MGI Sequence Detail 205 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 7
    cDNA 34
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38369
References
more
  • Summaries
    All 101
    Developmental Gene Expression 9
    Gene Ontology 19
    Phenotypes 44
  • Earliest
    J:113685 Boldin MP, et al., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995 Apr 7;270(14):7795-8
  • Latest
    J:226752 Kondylis V, et al., NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Nov 9;28(5):582-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory