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Cd244
Gene Detail
 Symbol
Name
ID
Cd244
CD244 natural killer cell receptor 2B4
MGI:109294
Synonyms 2B4, C9.1, F730046O15Rik, Nmrk
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:171559193-171585318 bp, + strand
From VEGA annotation of GRCm38

  26126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cd244

Human
homologs
Human Homolog CD244, CD244 molecule, natural killer cell receptor 2B4
NCBI Gene ID 51744
neXtProt AC  NX_Q9BZW8
Human Synonyms  2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Human Chr (Location)  1q23.3; chr1:160830160-160862902 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD244
Alleles
and
phenotypes
All alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (4)
Theiler Stages: 23
Assay TypeResults
RNA in situ 4
cDNA source data(13)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016914 (Evidence)
Ensembl Gene ModelENSMUSG00000004709 (Evidence)
Entrez Gene18106 (Evidence)
UniGene2299
DFCITC1584356, TC1590708, TC1591784
DoTSDT.101253299, DT.101306344, DT.101339827, DT.101361103, DT.87034283, DT.94277903
NIA Mouse Gene IndexU001092
PDB1Z2K, 2PTT, 2PTU
Consensus CDS ProjectCCDS35778.1
International Mouse Knockout Project StatusCd244
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016914 VEGA Gene Model | MGI Sequence Detail 26126 C57BL/6J ±  kb
transcript OTTMUST00000041041 VEGA | MGI Sequence Detail 3760 Not Applicable 
polypeptide OTTMUSP00000018385 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(5) UniProt(7)
Polymorphisms SNPs within 2kb(698 from dbSNP Build 137)    SNPs within 2kb including multiple locations(700)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR024304 Natural killer cell receptor 2B4
InterPro IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000001896 natural killer cell receptor 2B4
References (Earliest) J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
(Latest) J:208437 Liu D, et al., 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. J Exp Med. 2014 Feb 10;211(2):297-311
All references(62)
Other
accession IDs
MGD-MRK-38339, MGI:2442562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory