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Cd244
Gene Detail
Symbol

Name
ID
Cd244
CD244 natural killer cell receptor 2B4
MGI:109294
Synonyms
2B4, C9.1, F730046O15Rik, Nmrk
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:171559193-171609746 bp, + strand
From VEGA annotation of GRCm38

  50554 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CD244
Gene Tree: Cd244

Human
homologs
CD244, CD244 molecule, natural killer cell receptor 2B4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51744
neXtProt AC: NX_Q9BZW8

Human Synonyms: 2B4, NAIL, NKR2B4, Nmrk, SLAMF4

Human Chr (Location): 1q23.3; chr1:160830158-160862902 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD244

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors.
 
Interactions
Cd244 interacts with 286 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016914 (Evidence)
Ensembl Gene Model ENSMUSG00000004709 (Evidence)
Entrez Gene 18106 (Evidence)
UniGene 2299
DFCI TC1584356, TC1590708, TC1591784
DoTS DT.94277903, DT.87034283, DT.101253299, DT.101361103, DT.101339827, DT.101306344
NIA Mouse Gene Index U001092
PDB 2PTT, 1Z2K, 2PTU
Consensus CDS Project CCDS35778.1
International Mouse Phenotyping Consortium Status Cd244
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016914 VEGA Gene Model | MGI Sequence Detail 50554 C57BL/6J ±  kb
transcript OTTMUST00000041041 VEGA | MGI Sequence Detail 3760 Not Applicable 
polypeptide OTTMUSP00000018385 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(927 from dbSNP Build 137)    SNPs within 2kb including multiple locations(929)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR024304 Natural killer cell receptor 2B4
InterPro IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000001896 natural killer cell receptor 2B4
References
(Earliest) J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
(Latest) J:215924 Elishmereni M, et al., Complex 2B4 Regulation of Mast Cells and Eosinophils in Murine Allergic Inflammation. J Invest Dermatol. 2014 Dec;134(12):2928-37
All references(61)
Other
accession IDs
MGD-MRK-38339, MGI:2442562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory