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Cd244 Gene Detail
Summary
  • Symbol
    Cd244
  • Name
    CD244 natural killer cell receptor 2B4
  • Synonyms
    2B4, C9.1, F730046O15Rik, Nmrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:109294
    NCBI Gene: 18106
  • Gene Overview
    MyGene.info: CD244
Location & Maps
more
  • Sequence Map
    Chr1:171559193-171609746 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50554 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.52 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CD244, CD244 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD244, CD244 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2B4, NAIL, NKR2B4, Nmrk, SLAMF4
  • Links
    NCBI Gene ID: 51744
    neXtProt AC: NX_Q9BZW8

  • Chr Location
    1q23.3; chr1:160830158-160862902 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CD244 associations

Human Disease Mouse Models
       Rheumatoid Arthritis; RA   OMIM: 180300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Cd244
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016914 VEGA Gene Model | MGI Sequence Detail 50554 C57BL/6J ±  kb
transcript OTTMUST00000041041 VEGA | MGI Sequence Detail 3760 Not Applicable  
polypeptide OTTMUSP00000018385 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    912 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 13
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38339, MGI:2442562
References
more
  • Summaries
    All 61
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
  • Latest
    J:227366 Georgoudaki AM, et al., CD244 is expressed on dendritic cells and regulates their functions. Immunol Cell Biol. 2015 Jul;93(6):581-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory