Cd244
Gene Detail

Symbol Name ID

Cd244 CD244 natural killer cell receptor 2B4 MGI:109294

Synonyms

2B4, C9.1, F730046O15Rik, Nmrk

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr1:171559193-171585318 bp, + strand From VEGA annotation of GRCm38   26126 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Cd244

Human homologs

Human Homolog		CD244, CD244 molecule, natural killer cell receptor 2B4
NCBI Gene ID		51744
neXtProt AC		NX_Q9BZW8
Human Synonyms		2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Human Chr (Location)		1q23.3; chr1:160799950-160832692 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD244

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Component	external side of plasma membrane, integral to membrane, ...
Function	protein binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (4)
Theiler Stages: 23

Assay Type	Results
RNA in situ	4

cDNA source data(13)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016914 (Evidence)
Ensembl Gene Model	ENSMUSG00000004709 (Evidence)
Entrez Gene	18106 (Evidence)
UniGene	2299
DFCI	TC1584356, TC1590708, TC1591784
DoTS	DT.101253299, DT.101306344, DT.101339827, DT.101361103, DT.87034283, DT.94277903
NIA Mouse Gene Index	U001092
PDB	1Z2K, 2PTT, 2PTU
Consensus CDS Project	CCDS35778.1
International Mouse Knockout Project Status	Cd244

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016914	VEGA Gene Model | MGI Sequence Detail	26126	C57BL/6J
transcript	OTTMUST00000041041	VEGA | MGI Sequence Detail	3760	Not Applicable
polypeptide	OTTMUSP00000018385	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(48) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(322 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR024304	Natural killer cell receptor 2B4
InterPro	IPR024303	Natural killer cell receptor 2B4 immunoglobulin domain
InterPro	IPR015631	Signalling lymphocyte activation molecule family receptors
Protein Ontology	PR:000001896	natural killer cell receptor 2B4

References

(Earliest) J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
(Latest) J:189566 Tu CL, et al., Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct;132(10):2350-9
All references(59)

Other accession IDs

MGD-MRK-38339, MGI:2442562