Sequence Detail

ID/Version

Q07763 Q9JIE0 O88654 Q3UV86 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Natural killer cell receptor 2B4;AltName: Full=NK cell type I receptor protein 2B4; Short=NKR2B4;AltName: Full=Non-MHC restricted killing associated;AltName: Full=SLAM family member 4; Short=SLAMF4;AltName: Full=Signaling lym

Provider

SWISS-PROT

Sequence

Polypeptide 397 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd244a	CD244 molecule A	27	97	2	11

Sequence references in MGI

J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
J:63756 Kumaresan PR, et al., Polymorphism in the 2B4 gene of inbred mouse strains. Immunogenetics. 2000 Jul;51(8-9):758-61
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100630 Bloch-Queyrat C, et al., Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med. 2005 Jul 4;202(1):181-92
J:106459 Calpe S, et al., Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics. 2006 Feb;58(1):15-25
J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
J:126127 Velikovsky CA, et al., Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. Immunity. 2007 Oct;27(4):572-84
J:131269 Lee KM, et al., Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 2006 Apr 15;107(8):3181-8
J:151768 Dong Z, et al., Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol. 2009 Sep;10(9):973-80
J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
J:187430 Dong Z, et al., The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012 Jun 29;36(6):974-85
J:227366 Georgoudaki AM, et al., CD244 is expressed on dendritic cells and regulates their functions. Immunol Cell Biol. 2015 Jul;93(6):581-90
J:227396 Kambayashi T, et al., Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions. J Immunol. 2001 Dec 15;167(12):6706-10