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Rad50
Gene Detail
Symbol

Name
ID
Rad50
RAD50 homolog (S. cerevisiae)
MGI:109292
Synonyms
Mrell, Rad50l
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.98 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:53649519-53707319 bp, - strand
From VEGA annotation of GRCm38

  57801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA repair protein RAD50
Gene Tree: Rad50

Human
homologs
Human Homolog RAD50, RAD50 homolog (S. cerevisiae)
NCBI Gene ID 10111
neXtProt AC  NX_Q92878
Human Synonyms  hRad50, NBSLD, RAD502
Human Chr (Location)  5q31; chr5:132556924-132644621 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAD50
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted hypomorphic mutation exhibit growth defects, predisposition toward cancer, progressive loss of hematopoietic and spermatogenic stem cells, and lethality due to bone marrow depletion. A null mutation results in embryonic death.
 
Phenotype Images(1)
Interactions
Rad50 interacts with 251 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component chromosome, chromosome, telomeric region, ...
Function 3'-5' exonuclease activity, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (37)    Tissues (32)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 35
RT-PCR 2
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) Genomic(6) cDNA(101) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005644 (Evidence)
Ensembl Gene ModelENSMUSG00000020380 (Evidence)
Entrez Gene19360 (Evidence)
UniGene4888
DFCITC1578170, TC1593186
DoTSDT.91301296, DT.490612, DT.101740974, DT.97377840, DT.91400788
NIA Mouse Gene IndexU032768
EC3.6.-.-
Consensus CDS ProjectCCDS24684.1
International Mouse Knockout Project StatusRad50
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005644 VEGA Gene Model | MGI Sequence Detail 57801 C57BL/6J ±  kb
transcript OTTMUST00000012555 VEGA | MGI Sequence Detail 5153 Not Applicable 
polypeptide OTTMUSP00000005819 VEGA | MGI Sequence Detail 1312 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(13)
Polymorphisms
SNPs within 2kb(357 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004584 DNA repair protein Rad50
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR007517 Rad50 zinc hook
InterPro IPR013134 Zinc hook, Rad50
Protein Ontology PR:000013671 DNA repair protein RAD50
References
(Earliest) J:36725 Kim KK, et al., Mouse RAD50 has limited epitopic homology to p53 and is expressed in the adult myocardium. J Biol Chem. 1996 Nov 15;271(46):29255-64
(Latest) J:212499 Kim LK, et al., Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell. 2014 Apr 10;54(1):56-66
All references(52)
Other
accession IDs
MGD-MRK-38337, MGI:894309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory