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Trim28 Gene Detail
Summary
  • Symbol
    Trim28
  • Name
    tripartite motif-containing 28
  • Synonyms
    KAP-1, KRIP-1, MommeD9, Tif1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109274
    NCBI Gene: 21849
  • Gene Overview
    MyGene.info: TRIM28
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:12999114-13031035 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31922 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 7.73 cM, cytoband A2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRIM28, tripartite motif containing 28
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KAP1, PPP1R157, RNF96, TF1B, TIF1B
  • Links
    NCBI Gene ID: 10155
    neXtProt AC: NX_Q13263
    UniProt: Q13263

  • Chr Location
    19q13.43; chr19:58544469-58550715 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023882 VEGA Gene Model | MGI Sequence Detail 31922 C57BL/6J ±  kb
    transcript OTTMUST00000058340 VEGA | MGI Sequence Detail 3245 Not Applicable  
    polypeptide OTTMUSP00000028258 VEGA | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      131 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 22
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38319, MGI:2138086, MGI:3821594
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 23
      Gene Ontology 25
      Phenotypes 29
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:264191 Rousseaux MW, et al., Depleting Trim28 in adult mice is well tolerated and reduces levels of alpha-synuclein and tau. Elife. 2018 Jun 4;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory