About   Help   FAQ
Trim28
Gene Detail
Symbol

Name
ID
Trim28
tripartite motif-containing 28
MGI:109274
Synonyms
KAP-1, KRIP-1, MommeD9, Tif1b
Feature Type
protein coding gene
Genetic Map
Chromosome 7
7.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:13024152-13031035 bp, + strand
From VEGA annotation of GRCm38

  6884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Trim28

Human
homologs
Human Homolog TRIM28, tripartite motif containing 28
NCBI Gene ID 10155
neXtProt AC  NX_Q13263
Human Synonyms  KAP1, PPP1R157, RNF96, TF1B, TIF1B
Human Chr (Location)  19q13.4; chr19:58544469-58550715 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5.
 
Interactions
Trim28 interacts with 45 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (255)    Tissues (219)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 237
Northern blot 8
RT-PCR 8
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(21) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023882 (Evidence)
Ensembl Gene ModelENSMUSG00000005566 (Evidence)
Entrez Gene21849 (Evidence)
DFCITC1596456, TC1573856
DoTSDT.103584303, DT.101240114, DT.97372999, DT.97346152, DT.94300184, DT.111009682
EC6.3.2.-
Consensus CDS ProjectCCDS20823.1
International Mouse Knockout Project StatusTrim28
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023882 VEGA Gene Model | MGI Sequence Detail 6884 C57BL/6J ±  kb
transcript OTTMUST00000058340 VEGA | MGI Sequence Detail 3245 Not Applicable 
polypeptide OTTMUSP00000028258 VEGA | MGI Sequence Detail 834 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003649 B-box, C-terminal
InterPro IPR001487 Bromodomain
InterPro IPR000315 Zinc finger, B-box
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000016652 transcription intermediary factor 1-beta
References
(Earliest) J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
(Latest) J:212924 Katyal S, et al., Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
All references(83)
Other
accession IDs
MGD-MRK-38319, MGI:2138086, MGI:3821594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory