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Trim28 Gene Detail
Summary
  • Symbol
    Trim28
  • Name
    tripartite motif-containing 28
  • Synonyms
    KAP-1, KRIP-1, MommeD9, Tif1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109274
    NCBI Gene: 21849
  • Gene Overview
    MyGene.info: TRIM28
Location & Maps
more
  • Sequence Map
    Chr7:13024152-13031035 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6884 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRIM28, tripartite motif containing 28
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KAP1, PPP1R157, RNF96, TF1B, TIF1B
  • Links
    NCBI Gene ID: 10155
    neXtProt AC: NX_Q13263

  • Chr Location
    19q13.4; chr19:58544469-58550715 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    3
  • Gene trapped
    11
  • Targeted
    6
  • Incidental Mutations
Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023882 VEGA Gene Model | MGI Sequence Detail 6884 C57BL/6J ±  kb
transcript OTTMUST00000058340 VEGA | MGI Sequence Detail 3245 Not Applicable  
polypeptide OTTMUSP00000028258 VEGA | MGI Sequence Detail 834 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 21
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-38319, MGI:2138086, MGI:3821594
References
more
  • Summaries
    All 84
    Developmental Gene Expression 19
    Gene Ontology 21
    Phenotypes 23
  • Earliest
    J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
  • Latest
    J:230648 Dalgaard K, et al., Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 2016 Jan 28;164(3):353-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory