Gzmb
Gene Detail

Symbol Name ID

Gzmb granzyme B MGI:109267

Synonyms

CCP1, CCP-1/C11, Ctla1, Ctla-1, GZB

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr14:56258856-56262260 bp, - strand From NCBI annotation of GRCm38   3405 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:108184  Vertebrate Homology Class
1 human; 1 mouse; 4 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Gzmb

Human homologs

Human Homolog		GZMB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
NCBI Gene ID		3002
neXtProt AC		NX_P10144
Human Synonyms		CCPI, CGL1, CGL-1, CSPB, CSP-B, CTLA1, CTSGL1, HLP, SECT
Human Chr (Location)		14q11.2; chr14:25100160-25103432 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for a null allele show impaired CTL and NK cell cytolysis, and enhanced clearance of allogeneic and syngeneic tumor cells. Homozygotes for another null allele have defective CTL cytolysis and show impaired clearance of allogeneic tumor cells only if the selection cassette is retained.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	apoptotic process, cleavage of lamin involved in execution phase of apoptosis, ...
Component	cytoplasm, early endosome, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (4)
Theiler Stages: 20, 23, 28

Assay Type	Results
RNA in situ	4
RT-PCR	4

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(7) cDNA(26) Primer pair(2) Other(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000015437 (Evidence)
Entrez Gene	14939 (Evidence)
UniGene	14874
DFCI	TC1577032
DoTS	DT.99853247
NIA Mouse Gene Index	U035607
EC	3.4.21.79
PDB	2CP1
Consensus CDS Project	CCDS27147.1
International Mouse Knockout Project Status	Gzmb

Sequences

Length	Strain/Species
genomic	14939	NCBI Gene Model | MGI Sequence Detail	3405	C57BL/6J
transcript	NM_013542	RefSeq | MGI Sequence Detail	1418	C57BL/6
polypeptide	P04187	UniProt | EBI | MGI Sequence Detail	247	Not Applicable

All sequences(21) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(6) : SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000034060	granzyme B(G,H)

Graphical View of Protein Domain Structure

References

(Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:192609 Bian G, et al., Granzyme B-Mediated Damage of CD8+ T Cells Impairs Graft-versus-Tumor Effect. J Immunol. 2013 Feb 1;190(3):1341-50
All references(155)

Other accession IDs

MGD-MRK-2219, MGD-MRK-2229, MGD-MRK-38312, MGI:2145670