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Gzmb
Gene Detail
Symbol

Name
ID
Gzmb
granzyme B
MGI:109267
Synonyms
CCP1, CCP-1/C11, Ctla1, Ctla-1, GZB
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr14:56258856-56262260 bp, - strand
From NCBI annotation of GRCm38

  3405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: trypsin
Gene Tree: Gzmb
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show impaired CTL and NK cell cytolysis, and enhanced clearance of allogeneic and syngeneic tumor cells. Homozygotes for another null allele have defective CTL cytolysis and show impaired clearance of allogeneic tumor cells only if the selection cassette is retained.
 
Interactions
Gzmb interacts with 86 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic process, cytolysis, ...
Component cytolytic granule, cytoplasm
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 4
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(7) cDNA(26) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000015437 (Evidence)
Entrez Gene 14939 (Evidence)
UniGene 14874
DFCI TC1577032
DoTS DT.99853247
NIA Mouse Gene Index U035607
EC 3.4.21.79
PDB 2CP1
Consensus CDS Project CCDS27147.1
International Mouse Phenotyping Consortium Status Gzmb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14939 NCBI Gene Model | MGI Sequence Detail 3405 C57BL/6J ±  kb
transcript NM_013542 RefSeq | MGI Sequence Detail 1418 C57BL/6 
polypeptide P04187 UniProt | EBI | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(6) : SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(126)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000034060 granzyme B(G,H)
Graphical View of Protein Domain Structure
References
(Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:222475 Chaudhri G, et al., Vaccine-induced protection against orthopoxvirus infection is mediated through the combined functions of CD4 T cell-dependent antibody and CD8 T cell responses. J Virol. 2015 Feb;89(3):1889-99
All references(164)
Other
accession IDs
MGD-MRK-2219, MGD-MRK-2229, MGD-MRK-38312, MGI:2145670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory