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Gzmb
Gene Detail
 Symbol
Name
ID
Gzmb
granzyme B
MGI:109267
Synonyms CCP1, CCP-1/C11, Ctla1, Ctla-1, GZB
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr14:56258856-56262260 bp, - strand
From NCBI annotation of GRCm38

  3405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: trypsin
Gene Tree: Gzmb
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show impaired CTL and NK cell cytolysis, and enhanced clearance of allogeneic and syngeneic tumor cells. Homozygotes for another null allele have defective CTL cytolysis and show impaired clearance of allogeneic tumor cells only if the selection cassette is retained.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, cytolysis, ...
Component cytolytic granule, cytoplasm
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (4)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 4
RT-PCR 4
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(7) cDNA(26) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000015437 (Evidence)
Entrez Gene14939 (Evidence)
UniGene14874
DFCITC1577032
DoTSDT.99853247
NIA Mouse Gene IndexU035607
EC3.4.21.79
PDB2CP1
Consensus CDS ProjectCCDS27147.1
International Mouse Knockout Project StatusGzmb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14939 NCBI Gene Model | MGI Sequence Detail 3405 C57BL/6J ±  kb
transcript NM_013542 RefSeq | MGI Sequence Detail 1418 C57BL/6 
polypeptide P04187 UniProt | EBI | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(4)
Polymorphisms RFLP(6) : SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(126)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000034060 granzyme B(G,H)
Graphical View of Protein Domain Structure
References (Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:208773 Afshar-Sterle S, et al., Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014 Mar;20(3):283-90
All references(159)
Other
accession IDs
MGD-MRK-2219, MGD-MRK-2229, MGD-MRK-38312, MGI:2145670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory