Gzmb Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gzmb
granzyme B
MGI:109267

9 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gzmb^tm1Asmv/Gzmb^tm1Asmv involves: C57BL/6	normal immune system phenotype	J:203720
Gzmb^tm1Ley/Gzmb^tm1Ley B6.129S2-Gzmb^tm1Ley	impaired natural killer cell mediated cytotoxicity	J:113213
Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129S2/SvPas * C57BL/6	abnormal enzyme/coenzyme activity	J:113349
Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129S2/SvPas * C57BL/6J	decreased cytotoxic T cell cytolysis	J:23560
Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129X1/SvJ	abnormal NK cell physiology	J:126114
	decreased T cell apoptosis	J:126114
	decreased tumor growth/size	J:126114
	increased susceptibility to induced morbidity/mortality	J:126114
Gzmb^tm2.1Ley/Gzmb^tm2.1Ley 129X1/SvJ-Gzmb^tm2.1Ley	decreased cytotoxic T cell cytolysis	J:96538
Gzmb^tm2Ley/Gzmb^tm2Ley 129X1/SvJ-Gzmb^tm2Ley	abnormal immune system physiology	J:96538
Gzmb^tm2Ley/Gzmb^tm2Ley 129X1/SvJ-Gzmb^tm2Ley	decreased cytotoxic T cell cytolysis	J:96538

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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