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Adamts1
Gene Detail
Symbol

Name
ID
Adamts1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
MGI:109249
Synonyms
ADAM-TS1, ADAMTS-1, METH1, METH-1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
48.20 cM, cytoband C3-C5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:85793827-85803113 bp, - strand
From VEGA annotation of GRCm38

  9287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTS1
Gene Tree: Adamts1

Human
homologs
ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif, 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9510
neXtProt AC: NX_Q9UHI8

Human Synonyms: C3-C5, METH1

Human Chr (Location): 21q21.2; chr21:26836287-26845409 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Adamts1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture.
 
Human Diseases Modeled in Mice Using Adamts1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Adamts1 interacts with 291 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process heart trabecula formation, kidney development, ...
Component basement membrane, cytoplasm, ...
Function heparin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (431)    Tissues (285)    Images (95)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 294
Northern blot 11
Western blot 5
RT-PCR 27
RNase protection 88
cDNA source data(79)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ADAMTS1 ; Xenbase adamts1 ; ZFIN adamts1    NEW 
Molecular
reagents
All nucleic(88) Genomic(4) cDNA(79) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019935 (Evidence)
Ensembl Gene Model ENSMUSG00000022893 (Evidence)
Entrez Gene 11504 (Evidence)
UniGene 1421
DFCI TC1576782, TC1773700
DoTS DT.101314267, DT.490779, DT.97340198
NIA Mouse Gene Index U037242
EC 3.4.24.-
Consensus CDS Project CCDS28287.1
International Mouse Phenotyping Consortium Status Adamts1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019935 VEGA Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
transcript OTTMUST00000047513 VEGA | MGI Sequence Detail 4884 Not Applicable 
polypeptide OTTMUSP00000021492 VEGA | MGI Sequence Detail 968 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR013274 Peptidase M12B, ADAM-TS1
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003727 a disintegrin and metalloproteinase with thrombospondin motifs 1
References
(Earliest) J:37648 Kuno K, et al., Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997 Jan 3;272(1):556-62
(Latest) J:215459 Hellbach N, et al., Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
All references(66)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-38294

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory