About   Help   FAQ
Adamts1 Gene Detail
Summary
  • Symbol
    Adamts1
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
  • Synonyms
    ADAM-TS1, ADAMTS-1, METH1, METH-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109249
    NCBI Gene: 11504
  • Gene Overview
    MyGene.info: ADAMTS1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:85793827-85803113 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 48.20 cM, cytoband C3-C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109249
protein coding gene Chr16:85793827-85803113 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022973
protein coding gene Chr16:86441016-86450287 (-)
A/J MGP_AJ_G0022941
protein coding gene Chr16:82495621-82504894 (-)
AKR/J MGP_AKRJ_G0022911
protein coding gene Chr16:84906280-84915566 (-)
BALB/cJ MGP_BALBcJ_G0022943
protein coding gene Chr16:82946047-82955333 (-)
C3H/HeJ MGP_C3HHeJ_G0022705
protein coding gene Chr16:85497881-85507154 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023390
protein coding gene Chr16:89230960-89240246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020894
protein coding gene Chr16:80379348-80388657 (-)
CAST/EiJ MGP_CASTEiJ_G0022227
protein coding gene Chr16:85923516-85932820 (-)
CBA/J MGP_CBAJ_G0022674
protein coding gene Chr16:93032760-93042046 (-)
DBA/2J MGP_DBA2J_G0022808
protein coding gene Chr16:82362990-82372263 (-)
FVB/NJ MGP_FVBNJ_G0022783
protein coding gene Chr16:81542890-81552163 (-)
LP/J MGP_LPJ_G0022877
protein coding gene Chr16:86140257-86149528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022802
protein coding gene Chr16:97457566-97466839 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023408
protein coding gene Chr16:85419950-85429236 (-)
PWK/PhJ MGP_PWKPhJ_G0021969
protein coding gene Chr16:82525613-82535312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021800
protein coding gene Chr16:84866511-84888223 (-)
WSB/EiJ MGP_WSBEiJ_G0022275
protein coding gene Chr16:85667197-85676475 (-)



Homology
more
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3-C5, METH1
  • Links
    NCBI Gene ID: 9510
    neXtProt AC: NX_Q9UHI8
    UniProt: Q9UHI8

  • Chr Location
    21q21.3; chr21:26836287-26845409 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Adamts1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11504 NCBI Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
    transcript NM_009621 RefSeq | MGI Sequence Detail 4902 C57BL/6  
    polypeptide P97857 UniProt | EBI | MGI Sequence Detail 968 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 4
      cDNA 80
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38294
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:37648 Kuno K, et al., Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997 Jan 3;272(1):556-62
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory