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Adamts1 Gene Detail
Summary
  • Symbol
    Adamts1
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
  • Synonyms
    ADAM-TS1, ADAMTS-1, METH1, METH-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109249
    NCBI Gene: 11504
Location & Maps
more
  • Sequence Map
    Chr16:85793827-85803113 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9287 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
    Orthology source: HomoloGene
  • Synonyms
    C3-C5, METH1
  • Links
    NCBI Gene ID: 9510
    neXtProt AC: NX_Q9UHI8

  • Chr Location
    21q21.2; chr21:26836287-26845409 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Genomic Mutations
    1 involving Adamts1
  • Incidental Mutations
Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019935 VEGA Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
transcript OTTMUST00000047513 VEGA | MGI Sequence Detail 4884 Not Applicable  
polypeptide OTTMUSP00000021492 VEGA | MGI Sequence Detail 968 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    122 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 88
    Genomic 4
    cDNA 79
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38294
References
more
  • Summaries
    All 65
    Developmental Gene Expression 23
    Gene Ontology 12
    Phenotypes 16
  • Earliest
    J:37648 Kuno K, et al., Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997 Jan 3;272(1):556-62
  • Latest
    J:224408 Dubail J, et al., Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Matrix Biol. 2015 May-Jul;44-46:24-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory