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Adamts1 Gene Detail
Summary
  • Symbol
    Adamts1
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
  • Synonyms
    ADAM-TS1, ADAMTS-1, METH1, METH-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109249
    NCBI Gene: 11504
  • Gene Overview
    MyGene.info: ADAMTS1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:85793827-85803113 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9287 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 48.20 cM, cytoband C3-C5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3-C5, METH1
  • Links
    NCBI Gene ID: 9510
    neXtProt AC: NX_Q9UHI8
    UniProt: Q9UHI8

  • Chr Location
    21q21.3; chr21:26836287-26845409 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Adamts1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019935 VEGA Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
    transcript OTTMUST00000047513 VEGA | MGI Sequence Detail 4884 Not Applicable  
    polypeptide OTTMUSP00000021492 VEGA | MGI Sequence Detail 968 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      111 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 4
      cDNA 80
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38294
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:37648 Kuno K, et al., Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997 Jan 3;272(1):556-62
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory