Adamts1
Gene Detail

Symbol Name ID

Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 MGI:109249

Synonyms

ADAM-TS1, ADAMTS-1, METH1, METH-1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

48.20 cM, cytoband C3-C5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:85793827-85803113 bp, - strand From VEGA annotation of GRCm38   9287 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts1

Human homologs

Human Homolog		ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif, 1
NCBI Gene ID		9510
neXtProt AC		NX_Q9UHI8
Human Synonyms		C3-C5, METH1
Human Chr (Location)		21q21.2; chr21:28208606-28217728 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for targeted mutations that inactivate the gene display growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture.

 
Human Diseases Modeled Using Mouse Adamts1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	heart trabecula formation, kidney development, ...
Component	basement membrane, cytoplasmic vesicle, ...
Function	heparin binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (376)    Tissues (236)    Images (87)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	258
Northern blot	11
RT-PCR	19
RNase protection	88

cDNA source data(79)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) Genomic(4) cDNA(79) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019935 (Evidence)
Ensembl Gene Model	ENSMUSG00000022893 (Evidence)
Entrez Gene	11504 (Evidence)
UniGene	1421
DFCI	TC1576782, TC1773700
DoTS	DT.101314267, DT.490779, DT.97340198
NIA Mouse Gene Index	U037242
EC	3.4.24.-
Consensus CDS Project	CCDS28287.1
International Mouse Knockout Project Status	Adamts1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019935	VEGA Gene Model | MGI Sequence Detail	9287	C57BL/6J
transcript	OTTMUST00000047513	VEGA | MGI Sequence Detail	4884	Not Applicable
polypeptide	OTTMUSP00000021492	VEGA | MGI Sequence Detail	968	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR010294	ADAM-TS Spacer 1
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR013274	Peptidase M12B, ADAM-TS1
InterPro	IPR002870	Peptidase M12B, propeptide
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000003727	A disintegrin and metalloproteinase with thrombospondin motifs 1

References

(Earliest) J:37648 Kuno K, et al., Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997 Jan 3;272(1):556-62
(Latest) J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
All references(63)

Other accession IDs

MGD-MRK-38294