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Targeted Allele Detail
Symbol: Adamts1tm1Hku
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; targeted mutation 1, Hiroki Kurihara
MGI ID: MGI:2156168
Synonyms: ADAMTS-1 -
Gene: Adamts1  Location: Chr16:85590715-85600001 bp, - strand  Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
Alliance: Adamts1tm1Hku page
Germline Transmission:  Earliest citation of germline transmission: J:62260
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.6kb genomic fragment containing exons 2-4 was replaced with a neomycin selection cassette. RT-PCR analysis confirmed that the encoded transcript was not present in detectable levels in RNA derived from kidney of homozygous mice. (J:62260)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts1 Mutation:  39 strains or lines available
Original:  J:62260 Shindo T, et al., ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function [see comments]. J Clin Invest. 2000 May;105(10):1345-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory