About   Help   FAQ
Spin1 Gene Detail
Summary
  • Symbol
    Spin1
  • Name
    spindlin 1
  • Synonyms
    Spin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109242
    NCBI Gene: 20729
  • Gene Overview
    MyGene.info: SPIN1
Location & Maps
more
  • Sequence Map
    Chr13:51100880-51152546 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51667 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.04 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPIN1, spindlin 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SPIN1, spindlin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPIN, TDRD24
  • Links
    NCBI Gene ID: 10927
    neXtProt AC: NX_Q9Y657

  • Chr Location
    9q22.1; chr9:88388382-88478708 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    219
  • Chemically induced (other)
    1
  • Gene trapped
    214
  • Targeted
    4
  • Genomic Mutations
    1 involving Spin1
  • Incidental Mutations
Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021395 Ensembl Gene Model | MGI Sequence Detail 51667 C57BL/6J ±  kb
transcript ENSMUST00000095797 Ensembl | MGI Sequence Detail 4434 Not Applicable  
polypeptide ENSMUSP00000093473 Ensembl | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    131 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 341
    cDNA 338
    Primer pair 3

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-38287, MGI:2142957, MGI:2145170
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:38386 Oh B, et al., Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo. Development. 1997 Jan;124(2):493-503
  • Latest
    J:209348 Su X, et al., Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory