Spin1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spin1
spindlin 1
MGI:109242

34 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myf5^tm3(cre)Sor/Myf5⁺ Spin1^tm1.1Rosc/Spin1^tm1.1Rosc involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NTac	abnormal diaphragm morphology	J:302851
	abnormal forelimb morphology	J:302851
	abnormal M line morphology	J:302851
	abnormal myogenesis	J:302851
	abnormal neuromuscular synapse morphology	J:302851
	abnormal posture	J:302851
	abnormal skeletal muscle fiber morphology	J:302851
	abnormal skeletal muscle fiber type ratio	J:302851
	abnormal skeletal muscle morphology	J:302851
	abnormal soleus morphology	J:302851
	abnormal tibialis anterior morphology	J:302851
	absent gastric milk in neonates	J:302851
	cachexia	J:302851
	decreased body weight	J:302851
	decreased skeletal muscle fiber number	J:302851
	decreased skeletal muscle mass	J:302851
	increased skeletal muscle fiber size	J:302851
	neonatal lethality, incomplete penetrance	J:302851
	scoliosis	J:302851
	skeletal muscle degeneration	J:302851
	skeletal muscle fiber degeneration	J:302851
	skeletal muscle fiber necrosis	J:302851
	skeletal muscle fibrosis	J:302851
Spin1^{Gt(RRZ449)Byg}/Spin1^{Gt(RRZ449)Byg} B6.129P2-Spin1^{Gt(RRZ449)Byg}	abnormal female meiosis I arrest	J:204704
	postnatal lethality, complete penetrance	J:204704
	normal reproductive system phenotype	J:204704
Spin1^{tm1.1(KOMP)Vlcg}/Spin1⁺ C57BL/6N-Spin1^{tm1.1(KOMP)Vlcg}/J	abnormal optic disk morphology	J:211773
	hyperactivity	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased startle reflex	J:211773
	increased vertical activity	J:211773
	persistence of hyaloid vascular system	J:211773
Spin1^{tm1.1(KOMP)Vlcg}/Spin1^{tm1.1(KOMP)Vlcg} C57BL/6N-Spin1^{tm1.1(KOMP)Vlcg}/J	preweaning lethality, complete penetrance	J:211773
Spin1^tm1.2Rosc/Spin1^tm1.2Rosc involves: C57BL/6N * C57BL/6NTac	abnormal forelimb morphology	J:302851
	neonatal lethality, complete penetrance	J:302851

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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