Spin1^tm1.1Rosc
Targeted Allele Detail

Summary

• Symbol: Spin1^tm1.1Rosc
• Name: spindlin 1; targeted mutation 1.1, Roland Schule
• MGI ID: MGI:6511292
• Synonyms: Spin1^p
• Gene: Spin1 Location: Chr13:51254916-51306582 bp, + strand Genetic Position: Chr13, 26.04 cM
• Alliance: Spin1^tm1.1Rosc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302851
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT-flanked neomycin resistance gene were inserted upstream of exon 4. An F3-flanked puromycin resistance gene and a second loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassettes leaving exon 3 floxed. (J:302851)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spin1 Mutation: 99 strains or lines available

References

• Original: J:302851 Greschik H, et al., The histone code reader Spin1 controls skeletal muscle development. Cell Death Dis. 2017 Nov 23;8(11):e3173
• All: 1 reference(s)