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Pkn2
Gene Detail
Symbol

Name
ID
Pkn2
protein kinase N2
MGI:109211
Synonyms
6030436C20Rik, PRK2, Prkcl2, Stk7
Feature Type
protein coding gene
Genetic Map
Chromosome 3
66.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:142790902-142882004 bp, - strand
From VEGA annotation of GRCm38

  91103 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PKN2
Gene Tree: Pkn2

Human
homologs
PKN2, protein kinase N2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5586
neXtProt AC: NX_Q16513

Human Synonyms: Pak-2, PAK2, PRK2, PRKCL2, PRO2042, STK7

Human Chr (Location): 1p22.2; chr1:88684193-88836255 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(40) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pkn2 interacts with 406 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process apical junction assembly, apoptotic process, ...
Component apical junction complex, cell junction, ...
Function ATP binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(197)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) cDNA(197)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000036912 (Evidence)
Ensembl Gene Model ENSMUSG00000004591 (Evidence)
Entrez Gene 109333 (Evidence)
UniGene 244236
DFCI TC1575745, TC1589520, TC1592338, TC1598125, TC1615558, TC1707450, TC1733813
DoTS DT.101255742, DT.101389489, DT.101738514, DT.101738515, DT.55176715, DT.87045577, DT.91391965, DT.91437007, DT.97401024
NIA Mouse Gene Index U024714, U099907
EC 2.7.11.13
Consensus CDS Project CCDS51084.1
International Mouse Phenotyping Consortium Status Pkn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036912 VEGA Gene Model | MGI Sequence Detail 91103 C57BL/6J ±  kb
transcript OTTMUST00000094833 VEGA | MGI Sequence Detail 6207 Not Applicable 
polypeptide OTTMUSP00000052855 VEGA | MGI Sequence Detail 983 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(576 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011072 HR1 rho-binding repeat
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012786 serine/threonine-protein kinase N2
References
(Earliest) J:36722 Quilliam LA, et al., Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem. 1996 Nov 15;271(46):28772-6
(Latest) J:193187 Yasui T, et al., Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21022-7
All references(46)
Other
accession IDs
MGD-MRK-38255, MGI:1925929, MGI:2139749

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory