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Pkn2 Gene Detail
Summary
  • Symbol
    Pkn2
  • Name
    protein kinase N2
  • Synonyms
    6030436C20Rik, PRK2, Prkcl2, Stk7
  • Feature Type
    protein coding gene
  • IDs
    MGI:109211
    NCBI Gene: 109333
  • Gene Overview
    MyGene.info: PKN2
Location & Maps
more
  • Sequence Map
    Chr3:142790902-142882004 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91103 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PKN2, protein kinase N2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PKN2, protein kinase N2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Pak-2, PAK2, PRK2, PRKCL2, PRO2042, STK7
  • Links
    NCBI Gene ID: 5586
    neXtProt AC: NX_Q16513

  • Chr Location
    1p22.2; chr1:88684193-88836255 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2054
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PKN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    47
  • Gene trapped
    40
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Pkn2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036912 VEGA Gene Model | MGI Sequence Detail 91103 C57BL/6J ±  kb
transcript OTTMUST00000094833 VEGA | MGI Sequence Detail 6207 Not Applicable  
polypeptide OTTMUSP00000052855 VEGA | MGI Sequence Detail 983 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    575 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 197
    cDNA 197

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-38255, MGI:1925929, MGI:2139749
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:36722 Quilliam LA, et al., Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem. 1996 Nov 15;271(46):28772-6
  • Latest
    J:229595 Quetier I, et al., Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion. Cell Rep. 2016 Jan 26;14(3):440-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory