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Tradd
Gene Detail
Symbol

Name
ID
Tradd
TNFRSF1A-associated via death domain
MGI:109200
Synonyms
9130005N23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105258286-105264609 bp, - strand
From VEGA annotation of GRCm38

  6324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRADD
Protein SuperFamily: TNFR1-associated DEATH domain protein
Gene Tree: Tradd

Human
homologs
TRADD, TNFRSF1A-associated via death domain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8717
neXtProt AC: NX_Q15628

Human Synonyms: Hs.89862

Human Chr (Location): 16q22; chr16:67154185-67159909 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mutations can cause resistance to toxicity induced by TNF, LPS and poly(I:C), resistance to galactosamine and TNF-induced hepatitis, increased susceptibility to bacterial infection, and impaired formation of follicular dendritic cell networks and germinal centers in spleen.
 
Interactions
Tradd interacts with 82 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process apoptotic process, extrinsic apoptotic signaling pathway, ...
Component cytoplasm, cytoskeleton, ...
Function binding, bridging, death domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tradd    NEW 
Molecular
reagents
All nucleic(37) Genomic(1) cDNA(35) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027472 (Evidence)
Ensembl Gene Model ENSMUSG00000031887 (Evidence)
Entrez Gene 71609 (Evidence)
UniGene 264255
DFCI TC1581875, TC1596385
DoTS DT.491196
NIA Mouse Gene Index U030165
Consensus CDS Project CCDS22594.1
International Mouse Phenotyping Consortium Status Tradd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027472 VEGA Gene Model | MGI Sequence Detail 6324 C57BL/6J ±  kb
transcript OTTMUST00000067989 VEGA | MGI Sequence Detail 1689 Not Applicable 
polypeptide OTTMUSP00000034295 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR009095 TRADD, N-terminal
Protein Ontology PR:000002233 tumor necrosis factor receptor type 1-associated DEATH domain protein
References
(Earliest) J:35208 Pan MG, et al., Sequence, genomic organization, and chromosome localization of the mouse TRADD gene. J Inflamm. 1995-96;46(3):168-75
(Latest) J:185559 Chio II, et al., TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol. 2012 Jun;14(6):625-33
All references(54)
Other
accession IDs
MGD-MRK-38244, MGI:1918859, MGI:2142447

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory