About   Help   FAQ
Tradd
Gene Detail
 Symbol
Name
ID
Tradd
TNFRSF1A-associated via death domain
MGI:109200
Synonyms 9130005N23Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105258286-105264609 bp, - strand
From VEGA annotation of GRCm38

  6324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TNFR1-associated DEATH domain protein
Gene Tree: Tradd

Human
homologs
Human Homolog TRADD, TNFRSF1A-associated via death domain
NCBI Gene ID 8717
neXtProt AC  NX_Q15628
Human Synonyms  Hs.89862
Human Chr (Location)  16q22; chr16:67154185-67159909 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations can cause resistance to toxicity induced by TNF, LPS and poly(I:C), resistance to galactosamine and TNF-induced hepatitis, increased susceptibility to bacterial infection, and impaired formation of follicular dendritic cell networks and germinal centers in spleen.
 
Interactions
Tradd interacts with 82 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process apoptotic process, extrinsic apoptotic signaling pathway, ...
Component cytoplasm, cytoskeleton, ...
Function binding, bridging, death domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (8)   
Theiler Stages: 28
Assay TypeResults
RT-PCR 10
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(1) cDNA(35) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027472 (Evidence)
Ensembl Gene ModelENSMUSG00000031887 (Evidence)
Entrez Gene71609 (Evidence)
UniGene264255
DFCITC1581875, TC1596385
DoTSDT.491196
NIA Mouse Gene IndexU030165
Consensus CDS ProjectCCDS22594.1
International Mouse Knockout Project StatusTradd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027472 VEGA Gene Model | MGI Sequence Detail 6324 C57BL/6J ±  kb
transcript OTTMUST00000067989 VEGA | MGI Sequence Detail 1689 Not Applicable 
polypeptide OTTMUSP00000034295 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR009095 TRADD, N-terminal
Protein Ontology PR:000002233 tumor necrosis factor receptor type 1-associated DEATH domain protein
References (Earliest) J:35208 Pan MG, et al., Sequence, genomic organization, and chromosome localization of the mouse TRADD gene. J Inflamm. 1995-96;46(3):168-75
(Latest) J:185559 Chio II, et al., TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol. 2012 Jun;14(6):625-33
All references(55)
Other
accession IDs
MGD-MRK-38244, MGI:1918859, MGI:2142447

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory