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Kif21a Gene Detail
Summary
  • Symbol
    Kif21a
  • Name
    kinesin family member 21A
  • Synonyms
    mKIAA1708, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109188
    NCBI Gene: 16564
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:90817479-90934151 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 45.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1243 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109188
protein coding gene Chr15:90817478-90934547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022245
protein coding gene Chr15:92221317-92350289 (-)
A/J MGP_AJ_G0022204
protein coding gene Chr15:88668674-88784378 (-)
AKR/J MGP_AKRJ_G0022179
protein coding gene Chr15:91274715-91401893 (-)
BALB/cJ MGP_BALBcJ_G0022210
protein coding gene Chr15:88768037-88891556 (-)
C3H/HeJ MGP_C3HHeJ_G0021980
protein coding gene Chr15:91293008-91411518 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022655
protein coding gene Chr15:95567897-95710457 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020181
protein coding gene Chr15:84808524-84925116 (-)
CAST/EiJ MGP_CASTEiJ_G0021502
protein coding gene Chr15:92090048-92217034 (-)
CBA/J MGP_CBAJ_G0021947
protein coding gene Chr15:98811000-98941107 (-)
DBA/2J MGP_DBA2J_G0022074
protein coding gene Chr15:88108071-88227206 (-)
FVB/NJ MGP_FVBNJ_G0022053
protein coding gene Chr15:87153138-87269561 (-)
LP/J MGP_LPJ_G0022145
protein coding gene Chr15:92362567-92486910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022073
protein coding gene Chr15:103188347-103321148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022670
protein coding gene Chr15:91410665-91534953 (-)
PWK/PhJ MGP_PWKPhJ_G0021243
protein coding gene Chr15:88149570-88273342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021077
protein coding gene Chr15:91123596-91242774 (-)
WSB/EiJ MGP_WSBEiJ_G0021551
protein coding gene Chr15:91850792-91978662 (-)



Homology
more
  • Human Ortholog
    KIF21A, kinesin family member 21A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF21A, kinesin family member 21A
  • Synonyms
    CFEOM1, FEOM1, FEOM3A
  • Links
    NCBI Gene ID: 55605
    neXtProt AC: NX_Q7Z4S6
    UniProt: Q7Z4S6

  • Chr Location
    12q12; chr12:39293228-39443390 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Kif21a mouse models; 1 with human KIF21A associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice die neonatally with no apparent oculomotor nerve pathology. Mice harboring a humanized amino acid substitution show uni- or bilateral ptosis, globe retraction, reduced numbers of oculomotor nerve and abducens motor neurons, and altered extraocular muscle morphology and innervation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022629 Ensembl Gene Model | MGI Sequence Detail 116673 C57BL/6J ±  kb
    transcript ENSMUST00000088614 Ensembl | MGI Sequence Detail 6333 Not Applicable  
    polypeptide ENSMUSP00000085985 Ensembl | MGI Sequence Detail 1672 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 120
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38232, MGI:2146087
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:306456 Farini D, et al., A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Cell Rep. 2020 Jun 2;31(9):107703

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory