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Kif21a Gene Detail
Summary
  • Symbol
    Kif21a
  • Name
    kinesin family member 21A
  • Synonyms
    mKIAA1708, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109188
    NCBI Gene: 16564
  • Gene Overview
    MyGene.info: KIF21A
Location & Maps
more
  • Sequence Map
    Chr15:90933276-91049948 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      116673 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 45.86 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KIF21A, kinesin family member 21A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF21A, kinesin family member 21A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CFEOM1, FEOM1, FEOM3A
  • Links
    NCBI Gene ID: 55605
    neXtProt AC: NX_Q7Z4S6

  • Chr Location
    12q12; chr12:39293228-39443390 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF21A associations

Human Disease Mouse Models
       Fibrosis of Extraocular Muscles, Congenital, 1; CFEOM1   OMIM: 135700
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Kif21a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022629 Ensembl Gene Model | MGI Sequence Detail 116673 C57BL/6J ±  kb
transcript ENSMUST00000088614 Ensembl | MGI Sequence Detail 6439 Not Applicable  
polypeptide ENSMUSP00000085985 Ensembl | MGI Sequence Detail 1672 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1243 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 121
    cDNA 119
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-38232, MGI:2146087
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 3
    Phenotypes 23
  • Earliest
    J:63692 Marszalek JR, et al., Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. J Cell Biol. 1999 May 3;145(3):469-79
  • Latest
    J:213171 Cheng L, et al., Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Apr 16;82(2):334-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory