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Fgf13
Gene Detail
Symbol

Name
ID
Fgf13
fibroblast growth factor 13
MGI:109178
Synonyms
Fhf2
Feature Type
protein coding gene
Genetic Map
Chromosome X
33.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:59062145-59568071 bp, - strand
From VEGA annotation of GRCm38

  505927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3036  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Fgf13

Human
homologs
Human Homolog FGF13, fibroblast growth factor 13
NCBI Gene ID 2258
neXtProt AC  NX_Q92913
Human Synonyms  FGF-13, FGF2, FHF2, FHF-2
Human Chr (Location)  Xq26.3; chrX:138631573-139222889 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for a floxed allele activated in neurons or globally exhibit impaired neuronal polarization and migration, impaired spatial learning and memory, impaired object recognition, hyperactivity, increased anxiety- and depression-related behaviors and abnormal cerebral cortex.
 
Interactions
Fgf13 interacts with 281 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cerebral cortex cell migration, establishment of neuroblast polarity, ...
Component axon, cell projection, ...
Function beta-tubulin binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (159)    Tissues (139)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
RT-PCR 17
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(1) cDNA(23) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018392 (Evidence)
Ensembl Gene ModelENSMUSG00000031137 (Evidence)
Entrez Gene14168 (Evidence)
UniGene7995
DFCITC1583460, TC1636277, TC1667428
DoTSDT.111022807, DT.111022811, DT.60105189, DT.97354817
NIA Mouse Gene IndexU039401
Consensus CDS ProjectCCDS30157.1, CCDS72383.1
International Mouse Knockout Project StatusFgf13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018392 VEGA Gene Model | MGI Sequence Detail 505927 C57BL/6J ±  kb
transcript OTTMUST00000044387 VEGA | MGI Sequence Detail 2499 Not Applicable 
polypeptide OTTMUSP00000019940 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(16) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(1711 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1717)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007483 fibroblast growth factor 13
References
(Earliest) J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
(Latest) J:186253 Wu QF, et al., Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012 Jun 22;149(7):1549-64
All references(46)
Other
accession IDs
MGD-MRK-38222

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory