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Fgf13 Gene Detail
Summary
  • Symbol
    Fgf13
  • Name
    fibroblast growth factor 13
  • Synonyms
    Fhf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109178
    NCBI Gene: 14168
Location & Maps
more
  • Sequence Map
    ChrX:59062145-59568071 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      505927 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FGF13, fibroblast growth factor 13
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FGF13, fibroblast growth factor 13
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FGF-13, FGF2, FHF2, FHF-2
  • Links
    NCBI Gene ID: 2258
    neXtProt AC: NX_Q92913

  • Chr Location
    Xq26.3; chrX:138631573-139222889 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3036
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FGF13
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Males hemizgyous for a null allele die by E12.5. Heterozyous females for this allele develop spontaneous seizures and have increased susceptibility to hyperthermia-induced seizures and epilepsy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018392 VEGA Gene Model | MGI Sequence Detail 505927 C57BL/6J ±  kb
transcript OTTMUST00000044387 VEGA | MGI Sequence Detail 2499 Not Applicable  
polypeptide OTTMUSP00000019940 VEGA | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1711 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 31
    Genomic 1
    cDNA 23
    Primer pair 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38222
References
more
  • Summaries
    All 45
    Developmental Gene Expression 19
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
  • Latest
    J:222555 Puranam RS, et al., Disruption of Fgf13 Causes Synaptic Excitatory-Inhibitory Imbalance and Genetic Epilepsy and Febrile Seizures Plus. J Neurosci. 2015 Jun 10;35(23):8866-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory