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Fgf13 Gene Detail
Summary
  • Symbol
    Fgf13
  • Name
    fibroblast growth factor 13
  • Synonyms
    Fhf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109178
    NCBI Gene: 14168
  • Gene Overview
    MyGene.info: FGF13
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:59062145-59568071 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 33.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1728 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109178
protein coding gene ChrX:59062139-59585572 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035754
protein coding gene ChrX:54406793-54926109 (-)
A/J MGP_AJ_G0035736
protein coding gene ChrX:54627487-55135002 (-)
AKR/J MGP_AKRJ_G0035656
protein coding gene ChrX:56055766-56610066 (-)
BALB/cJ MGP_BALBcJ_G0035723
protein coding gene ChrX:54001738-54503807 (-)
C3H/HeJ MGP_C3HHeJ_G0035425
protein coding gene ChrX:54952759-55470756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036252
protein coding gene ChrX:55856482-56393116 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033104
protein coding gene ChrX:54497445-54998443 (-)
CAST/EiJ MGP_CASTEiJ_G0034718
protein coding gene ChrX:40748131-41262631 (-)
CBA/J MGP_CBAJ_G0035400
protein coding gene ChrX:57504048-58043930 (-)
DBA/2J MGP_DBA2J_G0035554
protein coding gene ChrX:54196690-54697270 (-)
FVB/NJ MGP_FVBNJ_G0035504
protein coding gene ChrX:53753615-54254524 (-)
LP/J MGP_LPJ_G0035642
protein coding gene ChrX:55014192-55517281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035540
protein coding gene ChrX:59068069-59596398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036268
protein coding gene ChrX:54444697-54962518 (-)
PWK/PhJ MGP_PWKPhJ_G0034413
protein coding gene ChrX:38972289-39476564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034258
protein coding gene ChrX:41557083-42097692 (-)
WSB/EiJ MGP_WSBEiJ_G0034861
protein coding gene ChrX:53924989-54451225 (-)



Homology
more
  • Human Ortholog
    FGF13, fibroblast growth factor 13
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FGF13, fibroblast growth factor 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGF-13, FGF2, FHF2, FHF-2
  • Links
    NCBI Gene ID: 2258
    neXtProt AC: NX_Q92913
    UniProt: Q92913

  • Chr Location
    Xq26.3-q27.1; chrX:138631573-139222889 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3036
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FGF13
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizgyous for a null allele die by E12.5. Heterozyous females for this allele develop spontaneous seizures and have increased susceptibility to hyperthermia-induced seizures and epilepsy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031137 Ensembl Gene Model | MGI Sequence Detail 505927 C57BL/6J ±  kb
    transcript ENSMUST00000033473 Ensembl | MGI Sequence Detail 2499 Not Applicable  
    polypeptide ENSMUSP00000033473 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 29
      Primer pair 9
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38222
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 21
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory