About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6729187
Allelic
Composition
Fgf13em1Xuzh/Y
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13em1Xuzh mutation (0 available); any Fgf13 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show a reduction of freezing time in contextual memory indicating impaired associated memory
• mice show a reduction of freezing time in cued memory indicating impaired associated memory
• mice show increased escape latency and reduced time spent in the target quadrant during the training process of the Morris water maze
• in the probe trail of the Morris water maze, mice show less preference for the target quadrant than controls
• mice exhibit reduction of immobility time in the tail suspension test indicating decreased depression-like behavior
• however, mice show no alterations in motor ability in the rotarod test, social interaction behavior in the three-chamber test. anxiety-related behavior, in the novel object recognition test and in spontaneous activity in the open field

cellular
• nearly 40% of cortical neurons grown in culture do not develop into polarized neurons
• cortical neurons grown in culture show increased axon branching
• the percentage of neurons remaining in the white matter or cortical layers V-VI is higher than in controls at P0 and P7 but majority of cortical neurons migrate into layers II-IV at P14, indicating delayed neuronal migration

nervous system
• nearly 40% of cortical neurons grown in culture do not develop into polarized neurons
• cortical neurons grown in culture show increased axon branching
• the percentage of neurons remaining in the white matter or cortical layers V-VI is higher than in controls at P0 and P7 but majority of cortical neurons migrate into layers II-IV at P14, indicating delayed neuronal migration
• mice show laminar defects in the cerebral cortex, with Cux1+ (marking superficial cortical neurons) neurons distributed in both layers II-IV and mislocated throughout layers V-VI, and reduced thickness of superficial cortical layer at P0 but compensated at P7
• axon arbors are more complex and axons project to both the contralateral somatosensory cortex (S1) and secondary somatosensory cortex (S2) cortical regions while in wild-type mice the axons mainly reach the contralateral S1 cortical region
• complexity of contralateral axon projection remains increased at P14
• dendritic spine density in pyramidal neurons from both S1 and CA1 hippocampal regions is decreased

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:307501


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory