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Cd59a Gene Detail
Summary
  • Symbol
    Cd59a
  • Name
    CD59a antigen
  • Synonyms
    Cd59, protectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109177
    NCBI Gene: 12509
  • Alliance
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:103926146-103945699 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.53 cM, cytoband E2-E4
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    16
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109177
protein coding gene Chr2:103926146-103945755 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026213
protein coding gene Chr2:106110970-106174783 (+)
A/J MGP_AJ_G0026175
protein coding gene Chr2:101724938-101755831 (+)
AKR/J MGP_AKRJ_G0026154
protein coding gene Chr2:104493028-104523513 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0025935
protein coding gene Chr2:104830107-104848380 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026635
protein coding gene Chr2:109664089-109697631 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0025399
protein coding gene Chr2:105315624-105321506 (+)
CBA/J MGP_CBAJ_G0025912
protein coding gene Chr2:113403731-113422128 (+)
DBA/2J MGP_DBA2J_G0026050
protein coding gene Chr2:101294472-101321841 (+)
FVB/NJ MGP_FVBNJ_G0026012
protein coding gene Chr2:100282369-100303757 (+)
LP/J MGP_LPJ_G0026153
protein coding gene Chr2:106253251-106277003 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026037
protein coding gene Chr2:117296057-117325532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026689
protein coding gene Chr2:104716222-104748234 (+)
PWK/PhJ MGP_PWKPhJ_G0025134
protein coding gene Chr2:100813016-100845529 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024934
protein coding gene Chr2:103913741-103931205 (+)
WSB/EiJ MGP_WSBEiJ_G0025464
protein coding gene Chr2:105395445-105427159 (+)



Homology
more
  • Human Ortholog
    CD59, CD59 molecule (CD59 blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD59, CD59 molecule (CD59 blood group)
  • Synonyms
    16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF20, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
  • Links
    NCBI Gene ID: 966
    neXtProt AC: NX_P13987
    UniProt: P13987

  • Chr Location
    11p13; chr11:33703010-33736479 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CD59 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal complement pathway, abnormal response to injury, altered susceptibility to viral infection, and abnormal CD4+ T cell morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032679 Ensembl Gene Model | MGI Sequence Detail 19554 C57BL/6J ±  kb
    transcript ENSMUST00000168176 Ensembl | MGI Sequence Detail 1806 Not Applicable  
    polypeptide ENSMUSP00000132774 Ensembl | MGI Sequence Detail 123 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 1
      cDNA 83
      Primer pair 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38221, MGI:2138824
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 52
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:270774 Modinger Y, et al., Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing. Am J Pathol. 2019 Jan;189(1):147-161

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory