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Cd59a Gene Detail
Summary
  • Symbol
    Cd59a
  • Name
    CD59a antigen
  • Synonyms
    Cd59, protectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109177
    NCBI Gene: 12509
Location & Maps
more
  • Sequence Map
    Chr2:104095801-104115354 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19554 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.53 cM, cytoband E2-E4
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CD59, CD59 molecule
  • Human Ortholog
    CD59, CD59 molecule
    Orthology source: HGNC
  • Synonyms
    16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF20, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
  • Links
    NCBI Gene ID: 966
    neXtProt AC: NX_P13987

  • Chr Location
    11p13; chr11:33703010-33736479 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    39
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Cd59a
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit abnormal complement pathway, abnormal response to injury, altered susceptibility to viral infection, and abnormal CD4+ T cell morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014930 VEGA Gene Model | MGI Sequence Detail 19554 C57BL/6J ±  kb
transcript OTTMUST00000035457 VEGA | MGI Sequence Detail 1691 Not Applicable  
polypeptide OTTMUSP00000015870 VEGA | MGI Sequence Detail 123 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    226 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001999 CD59A glycoprotein
  • InterPro Domains
    IPR027101 CD59 glycoprotein
    IPR016054 Ly-6 antigen/uPA receptor-like
Molecular
Reagents
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  • All nucleic 91
    Genomic 1
    cDNA 82
    Primer pair 8

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38221, MGI:2138824
References
more
  • Summaries
    All 75
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 45
  • Earliest
    J:38256 Powell MB, et al., Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J Immunol. 1997 Feb 15;158(4):1692-702
  • Latest
    J:230881 Bloom AC, et al., Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice. Bone. 2016 Mar;84:253-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory