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Cd59a
Gene Detail
 Symbol
Name
ID
Cd59a
CD59a antigen
MGI:109177
Synonyms Cd59, protectin
Feature Type protein coding gene
Genetic Map
Chromosome 2
54.53 cM, cytoband E2-E4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:104095801-104115354 bp, + strand
From VEGA annotation of GRCm38

  19554 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: CD59 antigen
Gene Tree: Cd59a
Alleles
and
phenotypes
All alleles(37) : Gene trapped(34) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal complement pathway, abnormal response to injury, altered susceptibility to viral infection, and abnormal CD4+ T cell morphology and physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell activation, negative regulation of activation of membrane attack complex, ...
Component anchored component of membrane, external side of plasma membrane, ...
Function complement binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (178)    Tissues (41)    Images (25)
Theiler Stages: 7, 11, 13, 16, 18, 23, 24, 25, 28
Assay TypeResults
RNA in situ 136
Western blot 7
RT-PCR 35
cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(91) Genomic(1) cDNA(82) Primer pair(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014930 (Evidence)
Ensembl Gene ModelENSMUSG00000032679 (Evidence)
Entrez Gene12509 (Evidence)
UniGene247265
DFCITC1577117, TC1589680, TC1679677
DoTSDT.87069220, DT.91400570
Consensus CDS ProjectCCDS16487.1
International Mouse Knockout Project StatusCd59a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014930 VEGA Gene Model | MGI Sequence Detail 19554 C57BL/6J ±  kb
transcript OTTMUST00000035457 VEGA | MGI Sequence Detail 1691 Not Applicable 
polypeptide OTTMUSP00000015870 VEGA | MGI Sequence Detail 123 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(255 from dbSNP Build 137)    SNPs within 2kb including multiple locations(345)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR027101 CD59 glycoprotein
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000001999 CD59A glycoprotein
References (Earliest) J:38256 Powell MB, et al., Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J Immunol. 1997 Feb 15;158(4):1692-702
(Latest) J:194520 Miwa T, et al., Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol. 2013 Apr 1;190(7):3552-9
All references(77)
Other
accession IDs
MGD-MRK-38221, MGI:2138824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory