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Grk5 Gene Detail
Summary
  • Symbol
    Grk5
  • Name
    G protein-coupled receptor kinase 5
  • Synonyms
    Gprk5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109161
    NCBI Gene: 14773
  • Gene Overview
    MyGene.info: GRK5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:60889749-61092553 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      202805 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GRK5, G protein-coupled receptor kinase 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRK5, G protein-coupled receptor kinase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPRK5
  • Links
    NCBI Gene ID: 2869
    neXtProt AC: NX_P34947
    UniProt: P34947

  • Chr Location
    10q26.11; chr10:119207685-119455619 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003228 Ensembl Gene Model | MGI Sequence Detail 202805 C57BL/6J ±  kb
    transcript ENSMUST00000003313 Ensembl | MGI Sequence Detail 3165 Not Applicable  
    polypeptide ENSMUSP00000003313 Ensembl | MGI Sequence Detail 590 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1445 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38205
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/02/2018
    MGI 6.12
    The Jackson Laboratory