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Grk5
Gene Detail
Symbol

Name
ID
Grk5
G protein-coupled receptor kinase 5
MGI:109161
Synonyms
Gprk5
Feature Type
protein coding gene
Genetic Map
Chromosome 19
56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:60889749-61092553 bp, + strand
From Ensembl annotation of GRCm38

  202805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GRK5
Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk5

Human
homologs
GRK5, G protein-coupled receptor kinase 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2869
neXtProt AC: NX_P34947

Human Synonyms: GPRK5

Human Chr (Location): 10q26.11; chr10:119207685-119455619 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress.
 
Interactions
Grk5 interacts with 198 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (172)    Tissues (108)    Images (91)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
In situ reporter (knock in) 116
Northern blot 12
RT-PCR 38
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grk5    NEW 
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000003228 (Evidence)
Entrez Gene 14773 (Evidence)
DFCI TC1584480, TC1603546, TC1625062, TC1697151
DoTS DT.60108295, DT.87049275, DT.94236622
NIA Mouse Gene Index U140581, U273262
EC 2.7.11.16
Consensus CDS Project CCDS29945.1
International Mouse Phenotyping Consortium Status Grk5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003228 Ensembl Gene Model | MGI Sequence Detail 202805 C57BL/6J ±  kb
transcript ENSMUST00000003313 Ensembl | MGI Sequence Detail 3165 Not Applicable 
polypeptide ENSMUSP00000003313 Ensembl | MGI Sequence Detail 590 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1464 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1466)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000008259 G protein-coupled receptor kinase 5
References
(Earliest) J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
(Latest) J:207205 Islam KN, et al., Regulation of nuclear factor kappaB (NF-kappaB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). J Biol Chem. 2013 Dec 13;288(50):35683-9
All references(56)
Other
accession IDs
MGD-MRK-38205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory