Grk5
Gene Detail

Symbol Name ID

Grk5 G protein-coupled receptor kinase 5 MGI:109161

Synonyms

Gprk5

Feature Type

protein coding gene

Genetic Map

Chromosome 19

56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:60889749-61092553 bp, + strand From Ensembl annotation of GRCm38   202805 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk5

Human homologs

Human Homolog		GRK5, G protein-coupled receptor kinase 5
NCBI Gene ID		2869
neXtProt AC		NX_P34947
Human Synonyms		GPRK5
Human Chr (Location)		10q26.11; chr10:120967197-121215131 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Homozygous mutation of this gene results in a decrease in thermal pain sensation.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	apoptotic process, desensitization of G-protein coupled receptor protein signaling pathway, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, G-protein coupled receptor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (172)    Tissues (109)    Images (91)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	6
In situ reporter (knock in)	116
Northern blot	12
RT-PCR	38

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(30) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000003228 (Evidence)
Entrez Gene	14773 (Evidence)
UniGene	279400
DFCI	TC1584480, TC1625062, TC1697151
DoTS	DT.60108295, DT.94236622
NIA Mouse Gene Index	U273262
EC	2.7.11.16
Consensus CDS Project	CCDS29945.1
International Mouse Knockout Project Status	Grk5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000003228	Ensembl Gene Model | MGI Sequence Detail	202805	C57BL/6J
transcript	ENSMUST00000003313	Ensembl | MGI Sequence Detail	3165	Not Applicable
polypeptide	ENSMUSP00000003313	Ensembl | MGI Sequence Detail	590	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(979 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000239	GPCR kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Protein Ontology	PR:000008259	G-protein coupled receptor kinase 5

References

(Earliest) J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
(Latest) J:191093 Wang L, et al., GRK5 ablation contributes to insulin resistance. Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):99-104
All references(53)

Other accession IDs

MGD-MRK-38205