Grk5 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grk5
G protein-coupled receptor kinase 5
MGI:109161

16 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grk5^{tm1b(KOMP)Mbp}/Grk5^{tm1b(KOMP)Mbp} C57BL/6N-Grk5^{tm1b(KOMP)Mbp}/Ucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	enlarged heart	J:211773
Grk5^tm1Dgen/Grk5^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	increased thermal nociceptive threshold	J:101679
Grk5^tm1Rjl/Grk5^tm1Rjl involves: 129S4/SvJaeSor	cardiac hypertrophy	J:212635
Grk5^tm1Rjl/Grk5^tm1Rjl involves: 129S4/SvJaeSor	decreased response of heart to induced stress	J:212635
Grk5^tm1Rjl/Grk5^tm1Rjl involves: 129S4/SvJaeSor * C57BL/6	abnormal CNS synaptic transmission	J:59179
	abnormal muscle contractility	J:96208
	decreased body temperature	J:59179
	decreased core body temperature	J:59179
	decreased locomotor activity	J:59179
	decreased thermal nociceptive threshold	J:59179
	increased airway responsiveness	J:96208
	increased salivation	J:59179
	tremors	J:59179
Grk5^tm2Rjl/Grk5⁺ B6.129S4-Grk5^tm2Rjl	no abnormal phenotype detected	J:152746
Grk5^tm2Rjl/Grk5^tm2Rjl Tg(Myh6-cre)2182Mds/0 involves: 129S4/SvJaeSor * C57BL/6J * FVB/N	cardiac hypertrophy	J:212635
	decreased response of heart to induced stress	J:212635

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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