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Stip1 Gene Detail
Summary
  • Symbol
    Stip1
  • Name
    stress-induced phosphoprotein 1
  • Synonyms
    Hop, Hsp70/Hsp90 organizing protein, IEF SSP 3521, p60, STI1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109130
    NCBI Gene: 20867
  • Gene Overview
    MyGene.info: STIP1
Location & Maps
more
  • Sequence Map
    Chr19:7020696-7040026 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19331 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    STIP1, stress induced phosphoprotein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STIP1, stress induced phosphoprotein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
  • Links
    NCBI Gene ID: 10963
    neXtProt AC: NX_P31948

  • Chr Location
    11q13; chr11:64185272-64204548 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4965
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: STIP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Gene trapped
    38
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a targeted allele exhibit embryonic lethality by E10.5, actute inflammation in the placental labyrinth, poorly formed neural tube and limb buds and increase double-strand breaks. Mice heterozygous for this allele exhibit susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20867 NCBI Gene Model | MGI Sequence Detail 19331 C57BL/6J ±  kb
transcript NM_016737 RefSeq | MGI Sequence Detail 2173 C57BL/6  
polypeptide Q60864 UniProt | EBI | MGI Sequence Detail 543 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015738 stress-induced-phosphoprotein 1
  • InterPro Domains
    IPR006636 Heat shock chaperonin-binding
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013105 Tetratricopeptide repeat 2
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 335
    cDNA 335

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38174
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:37862 Lassle M, et al., Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases. J Biol Chem. 1997 Jan 17;272(3):1876-84
  • Latest
    J:226548 Beraldo FH, et al., Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1). Dis Model Mech. 2015 Nov 1;8(11):1457-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory