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Tsc22d1 Gene Detail
Summary
  • Symbol
    Tsc22d1
  • Name
    TSC22 domain family, member 1
  • Synonyms
    Egr5, Tgfb1i4, TSC-22
  • Feature Type
    protein coding gene
  • IDs
    MGI:109127
    NCBI Gene: 21807
  • Gene Overview
    MyGene.info: TSC22D1
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:76414961-76507765 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 40.44 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1036 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109127
protein coding gene Chr14:76414635-76507765 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021580
protein coding gene Chr14:71346458-71444814 (+)
A/J MGP_AJ_G0021538
protein coding gene Chr14:69688916-69782940 (+)
AKR/J MGP_AKRJ_G0021515
protein coding gene Chr14:71769496-71865028 (+)
BALB/cJ MGP_BALBcJ_G0021545
protein coding gene Chr14:69496237-69589813 (+)
C3H/HeJ MGP_C3HHeJ_G0021322
protein coding gene Chr14:71485620-71581308 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021985
protein coding gene Chr14:74443536-74544236 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019523
protein coding gene Chr14:67287844-67380154 (+)
CAST/EiJ MGP_CASTEiJ_G0020839
protein coding gene Chr14:68199649-68296832 (+)
CBA/J MGP_CBAJ_G0021290
protein coding gene Chr14:76835489-76946157 (+)
DBA/2J MGP_DBA2J_G0021413
protein coding gene Chr14:69087491-69180133 (+)
FVB/NJ MGP_FVBNJ_G0021391
protein coding gene Chr14:68433664-68526417 (+)
LP/J MGP_LPJ_G0021483
protein coding gene Chr14:72472186-72567901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021418
protein coding gene Chr14:75529625-75629538 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022008
protein coding gene Chr14:71044533-71143607 (+)
PWK/PhJ MGP_PWKPhJ_G0020582
protein coding gene Chr14:65838183-65935188 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020419
protein coding gene Chr14:67013408-67103615 (+)
WSB/EiJ MGP_WSBEiJ_G0020892
protein coding gene Chr14:71396622-71493342 (+)



Homology
more
  • Human Ortholog
    TSC22D1, TSC22 domain family member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TSC22D1, TSC22 domain family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Ptg-2, TGFB1I4, TSC22
  • Links
    NCBI Gene ID: 8848
    neXtProt AC: NX_Q15714
    UniProt: Q15714

  • Chr Location
    13q14.11; chr13:44432143-44576565 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mcie homozygous for a null allele exhibit increased proliferation of bone marrow cells and decreased kidney and heart weights.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022010 Ensembl Gene Model | MGI Sequence Detail 92805 C57BL/6J ±  kb
    transcript ENSMUST00000048371 Ensembl | MGI Sequence Detail 4818 Not Applicable  
    polypeptide ENSMUSP00000044517 Ensembl | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR000580 TSC-22 / Dip / Bun
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 29
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36343, MGD-MRK-38171, MGI:107766, MGI:2145575, MGI:2145793
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 20
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:1170 Shibanuma M, et al., Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. J Biol Chem. 1992 May 25;267(15):10219-24
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory