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Tsc22d1 Gene Detail
Summary
  • Symbol
    Tsc22d1
  • Name
    TSC22 domain family, member 1
  • Synonyms
    Egr5, Tgfb1i4, TSC-22
  • Feature Type
    protein coding gene
  • IDs
    MGI:109127
    NCBI Gene: 21807
  • Gene Overview
    MyGene.info: TSC22D1
Location & Maps
more
  • Sequence Map
    Chr14:76414961-76507765 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92805 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 40.44 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TSC22D1, TSC22 domain family member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TSC22D1, TSC22 domain family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Ptg-2, TGFB1I4, TSC22
  • Links
    NCBI Gene ID: 8848
    neXtProt AC: NX_Q15714

  • Chr Location
    13q14; chr13:44432143-44576565 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (other)
    1
  • Gene trapped
    63
  • Targeted
    1
  • Transgenic
    1
  • Genomic Mutations
    1 involving Tsc22d1
  • Incidental Mutations
Mcie homozygous for a null allele exhibit increased proliferation of bone marrow cells and decreased kidney and heart weights.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026106 VEGA Gene Model | MGI Sequence Detail 92805 C57BL/6J ±  kb
transcript OTTMUST00000064452 VEGA | MGI Sequence Detail 4818 Not Applicable  
polypeptide OTTMUSP00000032006 VEGA | MGI Sequence Detail 1077 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1036 from dbSNP Build 142
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000016711 TSC22 domain family protein 1
  • InterPro Domains
    IPR000580 TSC-22 / Dip / Bun
Molecular
Reagents
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  • All nucleic 33
    cDNA 28
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-36343, MGD-MRK-38171, MGI:107766, MGI:2145575, MGI:2145793
References
more
  • Summaries
    All 55
    Developmental Gene Expression 19
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:1170 Shibanuma M, et al., Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. J Biol Chem. 1992 May 25;267(15):10219-24
  • Latest
    J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory