Mice homozygous for a knock-out allele show increased lethality associated with left ventricle rupture following left anterior descending coronary artery ligation. Aged mice exhibit reduced myocardial performance index, decreased coronary flow rate, and increased left ventricle thickness and weight.
|Process||negative regulation of endopeptidase activity, negative regulation of membrane protein ectodomain proteolysis, ...|
|Component||extracellular region, extracellular space, ...|
|Function||enzyme inhibitor activity, metal ion binding, ...|
|InterPro||IPR001820||Proteinase inhibitor I35, tissue inhibitor of metalloproteinase|
|InterPro||IPR027465||Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain|
|InterPro||IPR015614||Tissue inhibitor of metalloprotease 4|
|InterPro||IPR008993||Tissue inhibitor of metalloproteinases-like, OB-fold|
|Protein Ontology||PR:000016355||metalloproteinase inhibitor 4|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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