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Timp4
Gene Detail
Symbol

Name
ID
Timp4
tissue inhibitor of metalloproteinase 4
MGI:109125
Synonyms
TIMP-4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:115245616-115251849 bp, - strand
From Ensembl annotation of GRCm38

  6234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37748  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp4

Human
homologs
Human Homolog TIMP4, TIMP metallopeptidase inhibitor 4
NCBI Gene ID 7079
neXtProt AC  NX_Q99727
Human Chr (Location)  3p25; chr3:12153068-12159351 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show increased lethality associated with left ventricle rupture following left anterior descending coronary artery ligation. Aged mice exhibit reduced myocardial performance index, decreased coronary flow rate, and increased left ventricle thickness and weight.
 
Phenotype Images(3)
Interactions
Timp4 interacts with 107 markers (Mir30c-1, Mir30c-2, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of peptidase activity
Component extracellular region, extracellular space, ...
Function enzyme inhibitor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (63)    Tissues (19)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
Northern blot 12
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030317 (Evidence)
Entrez Gene110595 (Evidence)
DoTSDT.97335552, DT.94241103, DT.94241102, DT.60108987, DT.101266110
NIA Mouse Gene IndexU027750
Consensus CDS ProjectCCDS20438.1
International Mouse Knockout Project StatusTimp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030317 Ensembl Gene Model | MGI Sequence Detail 6234 C57BL/6J ±  kb
transcript ENSMUST00000032462 Ensembl | MGI Sequence Detail 1416 Not Applicable 
polypeptide ENSMUSP00000032462 Ensembl | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015614 Tissue inhibitor of metalloprotease 4
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016355 metalloproteinase inhibitor 4
References
(Earliest) J:48116 Greene J, et al., Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J Biol Chem. 1996 Nov 29;271(48):30375-80
(Latest) J:211441 Basu R, et al., TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Cardiovasc Res. 2013 Jun 1;98(3):360-71
All references(39)
Other
accession IDs
MGD-MRK-38169

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory