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Timp4
Gene Detail
Symbol

Name
ID
Timp4
tissue inhibitor of metalloproteinase 4
MGI:109125
Synonyms
TIMP-4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:115245616-115251849 bp, - strand
From Ensembl annotation of GRCm38

  6234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37748  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TIMP4
Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp4

Human
homologs
TIMP4, TIMP metallopeptidase inhibitor 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7079
neXtProt AC: NX_Q99727

Human Chr (Location): 3p25; chr3:12153068-12159351 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Genomic Mutations involving Timp4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show increased lethality associated with left ventricle rupture following left anterior descending coronary artery ligation. Aged mice exhibit reduced myocardial performance index, decreased coronary flow rate, and increased left ventricle thickness and weight.
 
Phenotype Images(3)
Interactions
Timp4 interacts with 107 markers (Mir30c-1, Mir30c-2, Mir100, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (63)    Tissues (19)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
Northern blot 12
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030317 (Evidence)
Entrez Gene 110595 (Evidence)
DoTS DT.101266110, DT.60108987, DT.94241102, DT.94241103, DT.97335552
NIA Mouse Gene Index U027750
Consensus CDS Project CCDS20438.1
International Mouse Phenotyping Consortium Status Timp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030317 Ensembl Gene Model | MGI Sequence Detail 6234 C57BL/6J ±  kb
transcript ENSMUST00000032462 Ensembl | MGI Sequence Detail 1416 Not Applicable 
polypeptide ENSMUSP00000032462 Ensembl | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015614 Tissue inhibitor of metalloprotease 4
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016355 metalloproteinase inhibitor 4
References
(Earliest) J:48116 Greene J, et al., Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J Biol Chem. 1996 Nov 29;271(48):30375-80
(Latest) J:219383 Shimoda M, et al., Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat Cell Biol. 2014 Sep;16(9):889-901
All references(40)
Other
accession IDs
MGD-MRK-38169

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory