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Vegfc Gene Detail
Summary
  • Symbol
    Vegfc
  • Name
    vascular endothelial growth factor C
  • Synonyms
    VEGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:109124
    NCBI Gene: 22341
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:54077606-54187096 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109491 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.20 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Flt4-L, LMPH1D, VRP
  • Links
    NCBI Gene ID: 7424
    neXtProt AC: NX_P49767
    UniProt: P49767

  • Chr Location
    4q34.3; chr4:176683534-176792745 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3962
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VEGFC
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Vegfc mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060617 VEGA Gene Model | MGI Sequence Detail 109491 C57BL/6J ±  kb
    transcript OTTMUST00000148273 VEGA | MGI Sequence Detail 2449 Not Applicable  
    polypeptide OTTMUSP00000077097 VEGA | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      904 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 10
      Primer pair 6
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38168, MGI:2142780
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 58
      Diseases 1
      Gene Ontology 17
      Phenotypes 26
    • Earliest
      J:37681 Kukk E, et al., VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996 Dec;122(12):3829-37
    • Latest
      J:259048 Liu X, et al., Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling. Sci Signal. 2018 Feb 27;11(519)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory