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Vegfc Gene Detail
Summary
  • Symbol
    Vegfc
  • Name
    vascular endothelial growth factor C
  • Synonyms
    VEGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:109124
    NCBI Gene: 22341
Location & Maps
more
  • Sequence Map
    Chr8:54077532-54186454 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      108923 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
    Orthology source: HomoloGene
  • Synonyms
    Flt4-L, LMPH1D, VRP
  • Links
    NCBI Gene ID: 7424
    neXtProt AC: NX_P49767

  • Chr Location
    4q34.3; chr4:176683534-176792745 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3962
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VEGFC
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Vegfc mouse models; 1 with human VEGFC associations

Human Disease Mouse Models
       Lymphedema, Hereditary, ID; LMPH1D   OMIM: 615907 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Vegfc
  • Incidental Mutations
Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22341 NCBI Gene Model | MGI Sequence Detail 108923 C57BL/6J ±  kb
transcript NM_009506 RefSeq | MGI Sequence Detail 1881 Not Specified  
polypeptide P97953 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    900 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 8
    Primer pair 5
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-38168, MGI:2142780
References
more
  • Summaries
    All 94
    Developmental Gene Expression 47
    Diseases 1
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:37681 Kukk E, et al., VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996 Dec;122(12):3829-37
  • Latest
    J:224939 Hare LM, et al., Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects. Dev Biol. 2015 Aug 1;404(1):14-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory