About   Help   FAQ
Vegfc
Gene Detail
Symbol

Name
ID
Vegfc
vascular endothelial growth factor C
MGI:109124
Synonyms
VEGF-C
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.20 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:54077532-54186454 bp, + strand
From NCBI annotation of GRCm38

  108923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vegfc

Human
homologs
Human Homolog VEGFC, vascular endothelial growth factor C
NCBI Gene ID 7424
neXtProt AC  NX_P49767
Human Synonyms  Flt4-L, LMPH1D, VRP
Human Chr (Location)  4q34.3; chr4:176683538-176792745 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human VEGFC
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(26) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.
 
Human Diseases Modeled Using Mouse Vegfc (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Vegfc interacts with 114 markers (Mir16-2, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process angiogenesis, cell differentiation, ...
Component extracellular region, extracellular space, ...
Function chemoattractant activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (95)    Tissues (32)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
Northern blot 6
RT-PCR 12
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(8) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031520 (Evidence)
Entrez Gene22341 (Evidence)
DFCITC1584502, TC1674337
DoTSDT.60102683
NIA Mouse Gene IndexU009343
Consensus CDS ProjectCCDS22306.1
International Mouse Knockout Project StatusVegfc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22341 NCBI Gene Model | MGI Sequence Detail 108923 C57BL/6J ±  kb
transcript NM_009506 RefSeq | MGI Sequence Detail 1881 Not Specified 
polypeptide P97953 UniProt | EBI | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(902 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004153 CXCXC repeat
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000017285 vascular endothelial growth factor C
Graphical View of Protein Domain Structure
References
(Earliest) J:37681 Kukk E, et al., VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996 Dec;122(12):3829-37
(Latest) J:209725 Jeltsch M, et al., CCBE1 enhances lymphangiogenesis via a disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation. 2014 May 13;129(19):1962-71
All references(92)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-38168, MGI:2142780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory