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Vegfc
Gene Detail
Symbol

Name
ID
Vegfc
vascular endothelial growth factor C
MGI:109124
Synonyms
VEGF-C
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.20 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:54077532-54186454 bp, + strand
From NCBI annotation of GRCm38

  108923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VEGFC
Gene Tree: Vegfc

Human
homologs
VEGFC, vascular endothelial growth factor C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7424
neXtProt AC: NX_P49767

Human Synonyms: Flt4-L, LMPH1D, VRP

Human Chr (Location): 4q34.3; chr4:176683534-176792745 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VEGFC

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(26) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.
 
Human Diseases Modeled in Mice Using Vegfc (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Vegfc interacts with 114 markers (Mir16-2, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process angiogenesis, cell differentiation, ...
Component extracellular region, extracellular space, ...
Function chemoattractant activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (95)    Tissues (32)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
Northern blot 6
RT-PCR 12
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vegfc ; ZFIN vegfc    NEW 
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(8) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031520 (Evidence)
Entrez Gene 22341 (Evidence)
DFCI TC1674337, TC1584502
DoTS DT.60102683
NIA Mouse Gene Index U009343
Consensus CDS Project CCDS22306.1
International Mouse Phenotyping Consortium Status Vegfc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22341 NCBI Gene Model | MGI Sequence Detail 108923 C57BL/6J ±  kb
transcript NM_009506 RefSeq | MGI Sequence Detail 1881 Not Specified 
polypeptide P97953 UniProt | EBI | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(902 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004153 CXCXC repeat
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000017285 vascular endothelial growth factor C
Graphical View of Protein Domain Structure
References
(Earliest) J:37681 Kukk E, et al., VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996 Dec;122(12):3829-37
(Latest) J:217615 Chen HI, et al., VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest. 2014 Nov;124(11):4899-914
All references(92)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-38168, MGI:2142780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory