Fzd5
Gene Detail

Symbol

Name
ID

Fzd5
frizzled homolog 5 (Drosophila)
MGI:108571

Synonyms

5330434N09Rik, Fz5

Feature Type

protein coding gene

Genetic Map

Chromosome 1
32.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:64730558-64737751 bp, - strand From VEGA annotation of GRCm38   7194 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd5

Human
homologs

Human Homolog		FZD5, frizzled class receptor 5
NCBI Gene ID		7855
neXtProt AC		NX_Q13467
Human Synonyms		C2orf31, HFZ5
Human Chr (Location)		2q33.3; chr2:207762586-207769419 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.

 

Interactions

Fzd5 interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (53 annotations)

Process	angiogenesis, anterior/posterior axis specification, embryo, ...
Component	cell surface, early endosome, ...
Function	G-protein coupled receptor activity, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (41 records)

Data Summary: Results (277)    Tissues (204)    Images (49)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	4
RNA in situ	211
RT-PCR	62

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(24) cDNA(14) Primer pair(9) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000047622 (Evidence)
Ensembl Gene Model	ENSMUSG00000045005 (Evidence)
Entrez Gene	14367 (Evidence)
DFCI	TC1617515, TC1584523, TC1582914
DoTS	DT.523094, DT.101735505
NIA Mouse Gene Index	U069932
Consensus CDS Project	CCDS15008.1
International Mouse Knockout Project Status	Fzd5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000047622	VEGA Gene Model | MGI Sequence Detail	7194	C57BL/6J
transcript	OTTMUST00000122780	VEGA | MGI Sequence Detail	6915	Not Applicable
polypeptide	OTTMUSP00000067243	VEGA | MGI Sequence Detail	585	Not Applicable

All sequences(37) RefSeq(5) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR026547	Frizzled-5
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007721	frizzled-5

References

(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(82)

Other
accession IDs

MGD-MRK-37615, MGI:1925523, MGI:2138230