Fzd5 MGI Mouse Gene Detail - MGI:108571 - frizzled class receptor 5

Fzd5 Gene Detail

Symbol

Fzd5
Name

frizzled class receptor 5
Synonyms

5330434N09Rik, Fz5

Feature Type

protein coding gene
IDs

MGI:108571
NCBI Gene: 14367
Gene Overview

MyGene.info: FZD5
Alliance

gene page

Sequence Map

Chr1:64730558-64737751 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

7194 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.74 cM
Mapping Data

5 experiments

Human Ortholog

FZD5, frizzled class receptor 5

Vertebrate Orthologs

10

Human Ortholog

FZD5, frizzled class receptor 5
Orthology source: HGNC, HomoloGene
Synonyms

C2orf31, HFZ5
Links

HGNC:4043

NCBI Gene ID: 7855

neXtProt AC: NX_Q13467

UniProt: Q13467
Chr Location

2q33.3; chr2:207762586-207769419 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2590
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FZD5
Protein SuperFamily

G protein-coupled receptor frizzled
Gene Tree

Fzd5

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

8
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Fzd5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.

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All GO Annotations

70
GO References

16

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

316
Tissues

229
cDNA Data

14
Literature Summary

47

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fzd5

ZFIN fzd5

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Fzd5 interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

30
RefSeq

4
UniProt

3
CCDS

CCDS15008.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000047622	VEGA Gene Model \| MGI Sequence Detail	7194	C57BL/6J	± kb
transcript	OTTMUST00000122780	VEGA \| MGI Sequence Detail	6915	Not Applicable
polypeptide	OTTMUSP00000067243	VEGA \| MGI Sequence Detail	585	Not Applicable

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SNPs within 2kb

48 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
Protein Ontology

PR:000007721 frizzled-5

(term hierarchy)
InterPro Domains

IPR037441 Frizzled-5, CRD domain

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, transmembrane domain

IPR017981 GPCR, family 2-like

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All nucleic 30

cDNA 16

Primer pair 12

Other 2

Microarray probesets 4

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MGD-MRK-37615, MGI:1925523, MGI:2138230

Summaries

All 96

Developmental Gene Expression 47

Gene Ontology 16

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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