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Fzd5 Gene Detail
Summary
  • Symbol
    Fzd5
  • Name
    frizzled class receptor 5
  • Synonyms
    5330434N09Rik, Fz5
  • Feature Type
    protein coding gene
  • IDs
    MGI:108571
    NCBI Gene: 14367
  • Gene Overview
    MyGene.info: FZD5
Location & Maps
more
  • Sequence Map
    Chr1:64730558-64737751 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7194 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.74 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FZD5, frizzled class receptor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD5, frizzled class receptor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C2orf31, HFZ5
  • Links
    NCBI Gene ID: 7855
    neXtProt AC: NX_Q13467

  • Chr Location
    2q33.3; chr2:207762586-207769419 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Fzd5
  • Incidental Mutations
Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047622 VEGA Gene Model | MGI Sequence Detail 7194 C57BL/6J ±  kb
transcript OTTMUST00000122780 VEGA | MGI Sequence Detail 6915 Not Applicable  
polypeptide OTTMUSP00000067243 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 24
    cDNA 14
    Primer pair 9
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37615, MGI:1925523, MGI:2138230
References
more
  • Summaries
    All 81
    Developmental Gene Expression 42
    Gene Ontology 15
    Phenotypes 17
  • Earliest
    J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
  • Latest
    J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory