About   Help   FAQ
Fzd5
Gene Detail
 Symbol
Name
ID
Fzd5
frizzled homolog 5 (Drosophila)
MGI:108571
Synonyms 5330434N09Rik, Fz5
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:64730560-64737750 bp, - strand
From Ensembl annotation of GRCm38

  7191 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd5

Human
homologs
Human Homolog FZD5, frizzled class receptor 5
NCBI Gene ID 7855
neXtProt AC  NX_Q13467
Human Synonyms  C2orf31, HFZ5
Human Chr (Location)  2q33.3; chr2:207762586-207769419 (-)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process angiogenesis, anterior/posterior axis specification, embryo, ...
Component cell projection, cell surface, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (281)    Tissues (207)    Images (49)
Theiler Stages: 1, 2, 3, 4, 5, 7, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 211
RT-PCR 66
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(14) Primer pair(9) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000045005 (Evidence)
Entrez Gene14367 (Evidence)
DFCITC1582914, TC1584523, TC1617515
DoTSDT.101735505, DT.523094
NIA Mouse Gene IndexU069932
Consensus CDS ProjectCCDS15008.1
International Mouse Knockout Project StatusFzd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045005 Ensembl Gene Model | MGI Sequence Detail 7191 C57BL/6J ±  kb
transcript ENSMUST00000063982 Ensembl | MGI Sequence Detail 6912 Not Applicable 
polypeptide ENSMUSP00000067783 Ensembl | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(5) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026547 Frizzled-5
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007721 frizzled-5
References (Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(80)
Other
accession IDs
MGD-MRK-37615, MGI:1925523, MGI:2138230

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory