Fzd5 MGI Mouse Gene Detail - MGI:108571 - frizzled class receptor 5

Symbol

Fzd5
Name

frizzled class receptor 5
Synonyms

5330434N09Rik, Fz5

Feature Type

protein coding gene
IDs

MGI:108571
NCBI Gene: 14367
Gene Overview

MyGene.info: FZD5
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:64730558-64737750 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.74 cM
Mapping Data

5 experiments

SNPs within 2kb

48 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108571	protein coding gene	Chr1:64730558-64737751 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016098	protein coding gene	Chr1:64909607-64916831 (-)
A/J	MGP_AJ_G0016081	protein coding gene	Chr1:62625353-62632548 (-)
AKR/J	MGP_AKRJ_G0016038	protein coding gene	Chr1:64384584-64391777 (-)
BALB/cJ	MGP_BALBcJ_G0016036	protein coding gene	Chr1:62721435-62728628 (-)
C3H/HeJ	MGP_C3HHeJ_G0015868	protein coding gene	Chr1:64656527-64663722 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016489	protein coding gene	Chr1:67422214-67429407 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014210	protein coding gene	Chr1:58686722-58693848 (-)
CAST/EiJ	MGP_CASTEiJ_G0015451	protein coding gene	Chr1:63919499-63926694 (-)
CBA/J	MGP_CBAJ_G0015840	protein coding gene	Chr1:69611698-69618891 (-)
DBA/2J	MGP_DBA2J_G0015941	protein coding gene	Chr1:62031975-62039166 (-)
FVB/NJ	MGP_FVBNJ_G0015944	protein coding gene	Chr1:61307851-61315052 (-)
LP/J	MGP_LPJ_G0016013	protein coding gene	Chr1:65813641-65822099 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015964	protein coding gene	Chr1:72478458-72485653 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016536	protein coding gene	Chr1:64363233-64370428 (-)
PWK/PhJ	MGP_PWKPhJ_G0015238	protein coding gene	Chr1:61423509-61430678 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015017	protein coding gene	Chr1:63851083-63858318 (-)
WSB/EiJ	MGP_WSBEiJ_G0015513	protein coding gene	Chr1:64070138-64077327 (-)

Human Ortholog

FZD5, frizzled class receptor 5

Vertebrate Orthologs

10

Human Ortholog

FZD5, frizzled class receptor 5
Orthology source: HomoloGene, HGNC
Synonyms

C2orf31, HFZ5
Links

HGNC:4043

NCBI Gene ID: 7855

neXtProt AC: NX_Q13467

UniProt: Q13467
Chr Location

2q33.3; chr2:207762586-207769419 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2590
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FZD5
Protein SuperFamily

G protein-coupled receptor frizzled
Gene Tree

Fzd5

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Phenotype Summary

34 phenotypes from 5 alleles in 8 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

8
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Fzd5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal. Mice homozygous for another null allele exhibit abnormal eye development with increased apoptosis and decreased retinal proliferation.

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All GO Annotations

70
GO References

16

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

951
Tissues

233
cDNA Data

15
Literature Summary

54

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fzd5

ZFIN fzd5

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Fzd5 interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS15008.1

Ensembl

ENSMUSG00000045005 (Evidence)
NCBI Gene

14367

			Length	Strain/Species	Flank
genomic	14367	NCBI Gene Model \| MGI Sequence Detail	7193	C57BL/6J	± kb
transcript	NM_022721	RefSeq \| MGI Sequence Detail	6930	C57BL/6
polypeptide	Q9EQD0	UniProt \| EBI \| MGI Sequence Detail	585	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007721 frizzled-5

(term hierarchy)
InterPro Domains

IPR037441 Frizzled-5, CRD domain

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, transmembrane domain

IPR017981 GPCR, family 2-like

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All nucleic 32

cDNA 17

Primer pair 12

Other 3

Microarray probesets 4

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MGD-MRK-37615, MGI:1925523, MGI:2138230

Summaries

All 104

Developmental Gene Expression 54

Gene Ontology 16

Phenotypes 21
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4)

TSS for Fzd5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11934	Chr1:64737735-64737756 (-)	4 bp
Tssr11933	Chr1:64737708-64737726 (-)	33 bp
Tssr11932	Chr1:64737595-64737612 (-)	146 bp
Tssr11931	Chr1:64737520-64737541 (-)	219 bp
Tssr11930	Chr1:64734391-64734396 (-)	3,356 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/10/2020 MGI 6.16