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Fzd5
Gene Detail
Symbol

Name
ID
Fzd5
frizzled homolog 5 (Drosophila)
MGI:108571
Synonyms
5330434N09Rik, Fz5
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:64730558-64737751 bp, - strand
From VEGA annotation of GRCm38

  7194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd5

Human
homologs
Human Homolog FZD5, frizzled class receptor 5
NCBI Gene ID 7855
neXtProt AC  NX_Q13467
Human Synonyms  C2orf31, HFZ5
Human Chr (Location)  2q33.3; chr2:207762586-207769419 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.
 
Interactions
Fzd5 interacts with 414 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process angiogenesis, anterior/posterior axis specification, embryo, ...
Component cell surface, early endosome, ...
Function G-protein coupled receptor activity, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (277)    Tissues (204)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 211
RT-PCR 62
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(14) Primer pair(9) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000047622 (Evidence)
Ensembl Gene ModelENSMUSG00000045005 (Evidence)
Entrez Gene14367 (Evidence)
DFCITC1582914, TC1617515, TC1584523
DoTSDT.101735505, DT.523094
NIA Mouse Gene IndexU069932
Consensus CDS ProjectCCDS15008.1
International Mouse Knockout Project StatusFzd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047622 VEGA Gene Model | MGI Sequence Detail 7194 C57BL/6J ±  kb
transcript OTTMUST00000122780 VEGA | MGI Sequence Detail 6915 Not Applicable 
polypeptide OTTMUSP00000067243 VEGA | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026547 Frizzled-5
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007721 frizzled-5
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(82)
Other
accession IDs
MGD-MRK-37615, MGI:1925523, MGI:2138230

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory