Macf1
Gene Detail

Symbol Name ID

Macf1 microtubule-actin crosslinking factor 1 MGI:108559

Synonyms

Acf7, Aclp7, mKIAA0465, trabeculin alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 4

57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr4:123349633-123684360 bp, - strand From VEGA annotation of GRCm38   334728 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Macf1

Alleles and phenotypes

All alleles(784) : Targeted(4) Gene trapped(780)
 

Mice homozygous for a null allele exhibit lethality before somitogenesis with failure of the primitive streak to form. Mice heterozygous for a knock-out and floxed allele activated in neurons exhibit impaired cortical neuron migration, respiratory distress, and early postnatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	ATP catabolic process, cell cycle arrest, ...
Component	actin cytoskeleton, cell cortex, ...
Function	actin binding, ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (273)    Tissues (91)    Images (42)
Theiler Stages: 9, 16, 17, 19, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	272

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(20)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008977 (Evidence)
Ensembl Gene Model	ENSMUSG00000028649 (Evidence)
Entrez Gene	11426 (Evidence)
DFCI	TC1574198, TC1585413, TC1592346, TC1595900, TC1598607, TC1638470, TC1723278
DoTS	DT.101213817, DT.101235091, DT.101249375, DT.532572, DT.91298256, DT.91337608, DT.94259331, DT.94377177, DT.97338788
NIA Mouse Gene Index	U077927
Consensus CDS Project	CCDS57294.1, CCDS57295.1
International Mouse Knockout Project Status	Macf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008977	VEGA Gene Model | MGI Sequence Detail	334728	C57BL/6J
transcript	OTTMUST00000047226	VEGA | MGI Sequence Detail	23402	Not Applicable
polypeptide	OTTMUSP00000021313	VEGA | MGI Sequence Detail	7353	Not Applicable

All sequences(130) RefSeq(6) UniProt(24)

Polymorphisms

RFLP(1) : SNPs(1301 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001589	Actinin-type, actin-binding, conserved site
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR001715	Calponin homology domain
InterPro	IPR018248	EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR003108	Growth-arrest-specific protein 2 domain
InterPro	IPR001101	Plectin repeat
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
Protein Ontology	PR:000010896	microtubule-actin cross-linking factor 1

References

(Earliest) J:36985 Bernier G, et al., Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins. Genomics. 1996 Nov 15;38(1):19-29
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(57)

Other accession IDs

MGD-MRK-37603, MGI:2140716