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Macf1
Gene Detail
Symbol

Name
ID
Macf1
microtubule-actin crosslinking factor 1
MGI:108559
Synonyms
Acf7, Aclp7, mKIAA0465, trabeculin alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:123349633-123684360 bp, - strand
From VEGA annotation of GRCm38

  334728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136191  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: MACF1
Gene Tree: Macf1

Human
homologs
MACF1, microtubule-actin crosslinking factor 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 23499
neXtProt AC: NX_Q9UPN3

Human Synonyms: ABP620, ACF7, MACF, OFC4

Human Chr (Location): 1p32-p31; chr1:39081417-39487138 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(773) : Gene trapped(768) Targeted(5)
Genomic Mutations involving Macf1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit lethality before somitogenesis with failure of the primitive streak to form. Mice heterozygous for a knock-out and floxed allele activated in neurons exhibit impaired cortical neuron migration, respiratory distress, and early postnatal lethality.
 
Interactions
Macf1 interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell cycle arrest, establishment or maintenance of cell polarity, ...
Component actin cytoskeleton, cell, ...
Function actin binding, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (322)    Tissues (148)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 321
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase macf1    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(21)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008977 (Evidence)
Ensembl Gene Model ENSMUSG00000028649 (Evidence)
Entrez Gene 11426 (Evidence)
DFCI TC1723278, TC1638470, TC1598607, TC1574198, TC1595900, TC1592346, TC1585413
DoTS DT.101235091, DT.101213817, DT.101249375, DT.91337608, DT.94259331, DT.91298256, DT.532572, DT.97338788, DT.94377177
NIA Mouse Gene Index U077927
Consensus CDS Project CCDS57294.1, CCDS57295.1
International Mouse Phenotyping Consortium Status Macf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008977 VEGA Gene Model | MGI Sequence Detail 334728 C57BL/6J ±  kb
transcript OTTMUST00000047226 VEGA | MGI Sequence Detail 23402 Not Applicable 
polypeptide OTTMUSP00000021313 VEGA | MGI Sequence Detail 7353 Not Applicable 

For the selected sequences
All sequences(186) RefSeq(62) UniProt(25)
Polymorphisms
RFLP(1) : SNPs within 2kb(1391 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1399)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003108 Growth-arrest-specific protein 2 domain
InterPro IPR001101 Plectin repeat
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
Protein Ontology PR:000031436 microtubule-actin cross-linking factor 1
References
(Earliest) J:36985 Bernier G, et al., Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins. Genomics. 1996 Nov 15;38(1):19-29
(Latest) J:216503 Ka M, et al., MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling. Dev Biol. 2014 Nov 1;395(1):4-18
All references(61)
Other
accession IDs
MGD-MRK-37603, MGI:2140716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory