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Macf1
Gene Detail
 Symbol
Name
ID
Macf1
microtubule-actin crosslinking factor 1
MGI:108559
Synonyms Acf7, Aclp7, mKIAA0465, trabeculin alpha
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:123349633-123684360 bp, - strand
From VEGA annotation of GRCm38

  334728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Macf1
Alleles
and
phenotypes
All alleles(784) : Targeted(4) Gene trapped(780)
 
Mice homozygous for a null allele exhibit lethality before somitogenesis with failure of the primitive streak to form. Mice heterozygous for a knock-out and floxed allele activated in neurons exhibit impaired cortical neuron migration, respiratory distress, and early postnatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process ATP catabolic process, cell cycle arrest, ...
Component actin cytoskeleton, cell, ...
Function actin binding, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (322)    Tissues (140)    Images (44)
Theiler Stages: 9, 16, 17, 19, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 321
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(20)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008977 (Evidence)
Ensembl Gene ModelENSMUSG00000028649 (Evidence)
Entrez Gene11426 (Evidence)
DFCITC1574198, TC1585413, TC1592346, TC1595900, TC1598607, TC1638470, TC1723278
DoTSDT.101213817, DT.101235091, DT.101249375, DT.532572, DT.91298256, DT.91337608, DT.94259331, DT.94377177, DT.97338788
NIA Mouse Gene IndexU077927
Consensus CDS ProjectCCDS57294.1, CCDS57295.1
International Mouse Knockout Project StatusMacf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008977 VEGA Gene Model | MGI Sequence Detail 334728 C57BL/6J ±  kb
transcript OTTMUST00000047226 VEGA | MGI Sequence Detail 23402 Not Applicable 
polypeptide OTTMUSP00000021313 VEGA | MGI Sequence Detail 7353 Not Applicable 

For the selected sequences
All sequences(174) RefSeq(50) UniProt(24)
Polymorphisms RFLP(1) : SNPs within 2kb(1391 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1399)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003108 Growth-arrest-specific protein 2 domain
InterPro IPR001101 Plectin repeat
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
Protein Ontology PR:000031436 microtubule-actin cross-linking factor 1
References (Earliest) J:36985 Bernier G, et al., Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins. Genomics. 1996 Nov 15;38(1):19-29
(Latest) J:206484 Fassett JT, et al., Microtubule Actin Cross-linking Factor 1 regulates cardiomyocyte microtubule distribution and adaptation to hemodynamic overload. PLoS One. 2013;8(9):e73887
All references(58)
Other
accession IDs
MGD-MRK-37603, MGI:2140716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory