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Tfpi2 Gene Detail
Summary
  • Symbol
    Tfpi2
  • Name
    tissue factor pathway inhibitor 2
  • Synonyms
    PP5/TFPI-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108543
    NCBI Gene: 21789
  • Gene Overview
    MyGene.info: TFPI2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:3962595-3988919 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 1.81 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108543
protein coding gene Chr6:3962589-3988978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030423
protein coding gene Chr6:695845-722516 (-)
A/J MGP_AJ_G0030396
protein coding gene Chr6:677737-705138 (-)
AKR/J MGP_AKRJ_G0030323
protein coding gene Chr6:721053-746848 (-)
BALB/cJ MGP_BALBcJ_G0030405
protein coding gene Chr6:674217-699954 (-)
C3H/HeJ MGP_C3HHeJ_G0030119
protein coding gene Chr6:697755-723921 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030860
protein coding gene Chr6:723877-751234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028071
protein coding gene Chr6:497545-522745 (-)
CAST/EiJ MGP_CASTEiJ_G0029520
protein coding gene Chr6:682998-714027 (-)
CBA/J MGP_CBAJ_G0030097
protein coding gene Chr6:744869-773454 (-)
DBA/2J MGP_DBA2J_G0030241
protein coding gene Chr6:675126-702258 (-)
FVB/NJ MGP_FVBNJ_G0030195
protein coding gene Chr6:681316-706376 (-)
LP/J MGP_LPJ_G0030328
protein coding gene Chr6:687250-715357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030231
protein coding gene Chr6:800830-831225 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030890
protein coding gene Chr6:660016-687731 (-)
PWK/PhJ MGP_PWKPhJ_G0029235
protein coding gene Chr6:607585-635678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029071
protein coding gene Chr6:702557-729935 (-)
WSB/EiJ MGP_WSBEiJ_G0029597
protein coding gene Chr6:673662-699033 (-)



Homology
more
  • Human Ortholog
    TFPI2, tissue factor pathway inhibitor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFPI2, tissue factor pathway inhibitor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP5, REF1, TFPI-2
  • Links
    NCBI Gene ID: 7980
    neXtProt AC: NX_P48307
    UniProt: P48307

  • Chr Location
    7q21.3; chr7:93885397-93890991 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029664 Ensembl Gene Model | MGI Sequence Detail 26325 C57BL/6J ±  kb
transcript ENSMUST00000031674 Ensembl | MGI Sequence Detail 1530 Not Applicable  
polypeptide ENSMUSP00000031674 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016280 tissue factor pathway inhibitor 2
  • InterPro Domains
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR008296 Tissue factor pathway inhibitor-like
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37587, MGI:2141606
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 4
  • Earliest
    J:37031 Miyagi Y, et al., Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. DNA Cell Biol. 1996 Nov;15(11):947-54
  • Latest
    J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory