About   Help   FAQ
Nbr1
Gene Detail
 Symbol
Name
ID
Nbr1
neighbor of Brca1 gene 1
MGI:108498
Synonyms mKIAA0049
Feature Type protein coding gene
Genetic Map
Chromosome 11
65.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:101552149-101581951 bp, + strand
From VEGA annotation of GRCm38

  29803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nbr1

Human
homologs
Human Homolog NBR1, neighbor of BRCA1 gene 1
NCBI Gene ID 4077
neXtProt AC  NX_Q14596
Human Synonyms  1A1-3B, IAI3B, M17S2
Human Chr (Location)  17q21.31; chr17:43170481-43211688 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(27) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice of the genetic truncation allele had an age-dependent increase in bone mass and bone mineral density. Mice homozygous for a floxed allele activated in T cells exhibit decreased ovalbumin-induced inflammation and defective Th2 polarization.
 
Interactions
Nbr1 interacts with 249 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process macroautophagy, negative regulation of osteoblast differentiation, ...
Component autophagic vacuole, cytoplasm, ...
Function metal ion binding, mitogen-activated protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (52)    Tissues (47)    Images (13)
Theiler Stages: 15, 17, 19, 23, 26, 27, 28
Assay TypeResults
RNA in situ 42
Western blot 7
RT-PCR 3
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000002872 (Evidence)
Ensembl Gene ModelENSMUSG00000017119 (Evidence)
Entrez Gene17966 (Evidence)
DFCITC1573298, TC1597272, TC1602309, TC1624190, TC1733358
DoTSDT.101176614, DT.101273329, DT.101392333, DT.101739059, DT.103581962, DT.494610, DT.97358297
NIA Mouse Gene IndexU043227
Consensus CDS ProjectCCDS25475.1, CCDS56810.1, CCDS56811.1
International Mouse Knockout Project StatusNbr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002872 VEGA Gene Model | MGI Sequence Detail 29803 C57BL/6J ±  kb
transcript OTTMUST00000005874 VEGA | MGI Sequence Detail 4789 Not Applicable 
polypeptide OTTMUSP00000002775 VEGA | MGI Sequence Detail 988 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(22) UniProt(12)
Polymorphisms SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000011015 next to BRCA1 gene 1 protein
References (Earliest) J:37713 Chambers JA, et al., Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics. 1996 Dec 15;38(3):305-13
(Latest) J:176955 Kuo TC, et al., Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol. 2011;13(10):1214-23
All references(47)
Other
accession IDs
MGD-MRK-37542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory