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Nbr1
Gene Detail
Symbol

Name
ID
Nbr1
neighbor of Brca1 gene 1
MGI:108498
Synonyms
mKIAA0049
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:101552149-101581951 bp, + strand
From VEGA annotation of GRCm38

  29803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NBR1
Gene Tree: Nbr1

Human
homologs
NBR1, neighbor of BRCA1 gene 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4077
neXtProt AC: NX_Q14596

Human Synonyms: 1A1-3B, IAI3B, M17S2, MIG19

Human Chr (Location): 17q21.31; chr17:43170471-43211689 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(27) Targeted(8)
Genomic Mutations involving Nbr1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice of the genetic truncation allele had an age-dependent increase in bone mass and bone mineral density. Mice homozygous for a floxed allele activated in T cells exhibit decreased ovalbumin-induced inflammation and defective Th2 polarization.
 
Interactions
Nbr1 interacts with 248 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process macroautophagy, negative regulation of osteoblast differentiation, ...
Component autophagosome, cytoplasm, ...
Function metal ion binding, mitogen-activated protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (52)    Tissues (47)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
Western blot 7
RT-PCR 3
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NBR1 ; Xenbase nbr1    NEW 
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002872 (Evidence)
Ensembl Gene Model ENSMUSG00000017119 (Evidence)
Entrez Gene 17966 (Evidence)
DFCI TC1573298, TC1624190, TC1602309, TC1597272, TC1733358
DoTS DT.101273329, DT.101176614, DT.101392333, DT.101739059, DT.103581962, DT.97358297, DT.494610
NIA Mouse Gene Index U043227
Consensus CDS Project CCDS25475.1, CCDS56810.1, CCDS56811.1
International Mouse Phenotyping Consortium Status Nbr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002872 VEGA Gene Model | MGI Sequence Detail 29803 C57BL/6J ±  kb
transcript OTTMUST00000005875 VEGA | MGI Sequence Detail 4654 Not Applicable 
polypeptide OTTMUSP00000002776 VEGA | MGI Sequence Detail 988 Not Applicable 

For the selected sequences
All sequences(131) RefSeq(22) UniProt(12)
Polymorphisms
SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000011015 next to BRCA1 gene 1 protein
References
(Earliest) J:37713 Chambers JA, et al., Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics. 1996 Dec 15;38(3):305-13
(Latest) J:215606 Hernandez ED, et al., A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell Metab. 2014 Sep 2;20(3):499-511
All references(49)
Other
accession IDs
MGD-MRK-37542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory