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Nbr1 Gene Detail
Summary
  • Symbol
    Nbr1
  • Name
    neighbor of Brca1 gene 1
  • Synonyms
    mKIAA0049
  • Feature Type
    protein coding gene
  • IDs
    MGI:108498
    NCBI Gene: 17966
  • Gene Overview
    MyGene.info: NBR1
Location & Maps
more
  • Sequence Map
    Chr11:101552149-101581951 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29803 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NBR1, neighbor of BRCA1 gene 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NBR1, neighbor of BRCA1 gene 1
    Orthology source: HomoloGene
  • Synonyms
    1A1-3B, IAI3B, M17S2, MIG19
  • Links
    NCBI Gene ID: 4077
    neXtProt AC: NX_Q14596

  • Chr Location
    17q21.31; chr17:43170471-43211689 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7438
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: NBR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Gene trapped
    27
  • Targeted
    8
  • Genomic Mutations
    1 involving Nbr1
  • Incidental Mutations
Homozygous mice of the genetic truncation allele had an age-dependent increase in bone mass and bone mineral density. Mice homozygous for a floxed allele activated in T cells exhibit decreased ovalbumin-induced inflammation and defective Th2 polarization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002872 VEGA Gene Model | MGI Sequence Detail 29803 C57BL/6J ±  kb
transcript OTTMUST00000005874 VEGA | MGI Sequence Detail 4789 Not Applicable  
polypeptide OTTMUSP00000002775 VEGA | MGI Sequence Detail 988 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    166 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 23
    Genomic 4
    cDNA 18
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37542
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:37713 Chambers JA, et al., Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics. 1996 Dec 15;38(3):305-13
  • Latest
    J:222820 Chang KH, et al., p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-kappaB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell Rep. 2014 Dec 24;9(6):2084-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory