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Fzd3
Gene Detail
Symbol

Name
ID
Fzd3
frizzled homolog 3 (Drosophila)
MGI:108476
Synonyms
D930050A07Rik, Fz3
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:65201026-65262463 bp, - strand
From VEGA annotation of GRCm38

  61438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23004  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd3

Human
homologs
Human Homolog FZD3, frizzled class receptor 3
NCBI Gene ID 7976
neXtProt AC  NX_Q9NPG1
Human Synonyms  Fz-3
Human Chr (Location)  8p21; chr8:28494205-28574268 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close.
 
Interactions
Fzd3 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (63 records)
Data Summary: Results (361)    Tissues (283)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 299
RT-PCR 62
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(18) Primer pair(8) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000020983 (Evidence)
Ensembl Gene ModelENSMUSG00000007989 (Evidence)
Entrez Gene14365 (Evidence)
DFCITC1585394, TC1603679, TC1644150, TC1689814
DoTSDT.102549418, DT.102555530, DT.94179317, DT.522566
NIA Mouse Gene IndexU178616, U035691, U035689
Consensus CDS ProjectCCDS27212.1
International Mouse Knockout Project StatusFzd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020983 VEGA Gene Model | MGI Sequence Detail 61438 C57BL/6J ±  kb
transcript OTTMUST00000049619 VEGA | MGI Sequence Detail 4157 Not Applicable 
polypeptide OTTMUSP00000023022 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026553 Frizzled-3, chordata
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007720 frizzled-3
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:212111 Hua ZL, et al., Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E3005-14
All references(107)
Other
accession IDs
MGD-MRK-37520, MGI:2145736, MGI:2445148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory