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Fzd3
Gene Detail
 Symbol
Name
ID
Fzd3
frizzled homolog 3 (Drosophila)
MGI:108476
Synonyms D930050A07Rik, Fz3
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:65201026-65262463 bp, - strand
From VEGA annotation of GRCm38

  61438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23004  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd3

Human
homologs
Human Homolog FZD3, frizzled class receptor 3
NCBI Gene ID 7976
neXtProt AC  NX_Q9NPG1
Human Synonyms  Fz-3
Human Chr (Location)  8p21; chr8:28494205-28574268 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close.
 
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process canonical Wnt signaling pathway, cell proliferation in midbrain, ...
Component apical part of cell, apical plasma membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (360)    Tissues (280)    Images (37)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 299
RT-PCR 61
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(18) Primer pair(7) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000020983 (Evidence)
Ensembl Gene ModelENSMUSG00000007989 (Evidence)
Entrez Gene14365 (Evidence)
DFCITC1585394, TC1603679, TC1644150, TC1689814
DoTSDT.102549418, DT.102555530, DT.522566, DT.94179317
NIA Mouse Gene IndexU035689, U035691, U178616
Consensus CDS ProjectCCDS27212.1
International Mouse Knockout Project StatusFzd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020983 VEGA Gene Model | MGI Sequence Detail 61438 C57BL/6J ±  kb
transcript OTTMUST00000049619 VEGA | MGI Sequence Detail 4157 Not Applicable 
polypeptide OTTMUSP00000023022 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026553 Frizzled-3, chordata
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007720 frizzled-3
References (Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(100)
Other
accession IDs
MGD-MRK-37520, MGI:2145736, MGI:2445148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory