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Fzd3 Gene Detail
Summary
  • Symbol
    Fzd3
  • Name
    frizzled class receptor 3
  • Synonyms
    D930050A07Rik, Fz3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108476
    NCBI Gene: 14365
  • Gene Overview
    MyGene.info: FZD3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:65201026-65262463 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61438 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.09 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FZD3, frizzled class receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD3, frizzled class receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fz-3
  • Links
    NCBI Gene ID: 7976
    neXtProt AC: NX_Q9NPG1
    UniProt: Q9NPG1

  • Chr Location
    8p21.1; chr8:28494205-28574268 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fzd3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020983 VEGA Gene Model | MGI Sequence Detail 61438 C57BL/6J ±  kb
    transcript OTTMUST00000049619 VEGA | MGI Sequence Detail 4157 Not Applicable  
    polypeptide OTTMUSP00000023022 VEGA | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      204 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 18
      Primer pair 10
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-37520, MGI:2145736, MGI:2445148
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 85
      Diseases 1
      Gene Ontology 20
      Phenotypes 30
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:261380 Concepcion D, et al., Tbx6 controls left-right asymmetry through regulation of Gdf1. Biol Open. 2018 May 4;7(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory