Fzd6
Gene Detail

Symbol Name ID

Fzd6 frizzled homolog 6 (Drosophila) MGI:108474

Synonyms

Fz6

Feature Type

protein coding gene

Genetic Map

Chromosome 15

15.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:39006280-39038186 bp, + strand From Ensembl annotation of GRCm38   31907 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd6 ± 2 cM)

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd6

Human ortholog

FZD6 frizzled family receptor 6 NCBI Gene ID 8323
Human Synonyms: FZ6, FZ-6, HFZ6, NDNC10
Human Chr8:104310661-104345094 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human FZD6 (1)

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	angiogenesis, axonogenesis, ...
Component	apical part of cell, apicolateral plasma membrane, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (48 records)
Data Summary: Results (510)    Tissues (296)    Images (112)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	306
In situ reporter (knock in)	99
Northern blot	3
RT-PCR	102

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(13) Primer pair(8) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000022297 (Evidence)
Entrez Gene	14368 (Evidence)
DFCI	TC1580206, TC1728399
DoTS	DT.101361092, DT.40156000, DT.55156594
NIA Mouse Gene Index	U016198
Consensus CDS Project	CCDS27441.1
International Mouse Knockout Project Status	Fzd6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022297	Ensembl Gene Model | MGI Sequence Detail	31907	C57BL/6J
transcript	ENSMUST00000179165	Ensembl | MGI Sequence Detail	4077	Not Applicable
polypeptide	ENSMUSP00000136328	Ensembl | MGI Sequence Detail	709	Not Applicable

All sequences(30) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(145 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026543	Frizzled-6
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007722	frizzled-6

References

(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:187523 Nishimura T, et al., Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012 May 25;149(5):1084-97
All references(87)

Other accession IDs

MGD-MRK-37518