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Fzd6 Gene Detail
Summary
  • Symbol
    Fzd6
  • Name
    frizzled class receptor 6
  • Synonyms
    Fz6
  • Feature Type
    protein coding gene
  • IDs
    MGI:108474
    NCBI Gene: 14368
  • Gene Overview
    MyGene.info: FZD6
Location & Maps
more
  • Sequence Map
    Chr15:39006280-39038186 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31907 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FZD6, frizzled class receptor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD6, frizzled class receptor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FZ6, FZ-6, HFZ6, NDNC10
  • Links
    NCBI Gene ID: 8323
    neXtProt AC: NX_O60353

  • Chr Location
    8q22.3-q23.1; chr8:103298433-103332866 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FZD6 associations

Human Disease Mouse Models
       Nail Disorder, Nonsyndromic Congenital, 10; NDNC10   OMIM: 614157
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Targeted
    8
  • Genomic Mutations
    2 involving Fzd6
  • Incidental Mutations
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 31907 C57BL/6J ±  kb
transcript ENSMUST00000179165 Ensembl | MGI Sequence Detail 4077 Not Applicable  
polypeptide ENSMUSP00000136328 Ensembl | MGI Sequence Detail 709 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    274 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 13
    Primer pair 11
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37518
References
more
  • Summaries
    All 96
    Developmental Gene Expression 55
    Gene Ontology 13
    Phenotypes 24
  • Earliest
    J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
  • Latest
    J:228792 Chang H, et al., The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Dev Biol. 2016 Jan 1;409(1):181-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory