About   Help   FAQ
Fzd6
Gene Detail
 Symbol
Name
ID
Fzd6
frizzled homolog 6 (Drosophila)
MGI:108474
Synonyms Fz6
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:39006280-39038186 bp, + strand
From Ensembl annotation of GRCm38

  31907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd6

Human
homologs
Human Homolog FZD6, frizzled class receptor 6
NCBI Gene ID 8323
neXtProt AC  NX_O60353
Human Synonyms  FZ6, FZ-6, HFZ6, NDNC10
Human Chr (Location)  8q22.3-q23.1; chr8:103298433-103332866 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FZD6
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
 
Interactions
Fzd6 interacts with 277 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process angiogenesis, axonogenesis, ...
Component apical part of cell, apicolateral plasma membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (511)    Tissues (299)    Images (113)
Theiler Stages: 1, 2, 3, 4, 5, 7, 9, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 99
Northern blot 3
RT-PCR 103
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(13) Primer pair(9) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022297 (Evidence)
Entrez Gene14368 (Evidence)
DFCITC1580206, TC1728399
DoTSDT.101361092, DT.40156000, DT.55156594
NIA Mouse Gene IndexU016198
Consensus CDS ProjectCCDS27441.1
International Mouse Knockout Project StatusFzd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 31907 C57BL/6J ±  kb
transcript ENSMUST00000179165 Ensembl | MGI Sequence Detail 4077 Not Applicable 
polypeptide ENSMUSP00000136328 Ensembl | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026543 Frizzled-6
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007722 frizzled-6
References (Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:206576 Fukuda T, et al., Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409
All references(96)
Other
accession IDs
MGD-MRK-37518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory