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Fzd6
Gene Detail
Symbol

Name
ID
Fzd6
frizzled homolog 6 (Drosophila)
MGI:108474
Synonyms
Fz6
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:39006280-39038186 bp, + strand
From Ensembl annotation of GRCm38

  31907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FZD6
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd6

Human
homologs
FZD6, frizzled class receptor 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8323
neXtProt AC: NX_O60353

Human Synonyms: FZ6, FZ-6, HFZ6, NDNC10

Human Chr (Location): 8q22.3-q23.1; chr8:103298433-103332866 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FZD6

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
 
Interactions
Fzd6 interacts with 277 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (55 records)
Data Summary: Results (511)    Tissues (298)    Images (113)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 99
Northern blot 3
RT-PCR 103
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fzd6 ; ZFIN fzd6    NEW 
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(13) Primer pair(9) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000022297 (Evidence)
Entrez Gene 14368 (Evidence)
DFCI TC1580206, TC1728399
DoTS DT.101361092, DT.55156594, DT.40156000
NIA Mouse Gene Index U016198
Consensus CDS Project CCDS27441.1
International Mouse Phenotyping Consortium Status Fzd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 31907 C57BL/6J ±  kb
transcript ENSMUST00000022906 Ensembl | MGI Sequence Detail 4081 Not Applicable 
polypeptide ENSMUSP00000022906 Ensembl | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026543 Frizzled-6
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007722 frizzled-6
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(97)
Other
accession IDs
MGD-MRK-37518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory