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Fzd6 Gene Detail
Summary
  • Symbol
    Fzd6
  • Name
    frizzled class receptor 6
  • Synonyms
    Fz6
  • Feature Type
    protein coding gene
  • IDs
    MGI:108474
    NCBI Gene: 14368
  • Gene Overview
    MyGene.info: FZD6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:39006034-39038188 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32155 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.22 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FZD6, frizzled class receptor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD6, frizzled class receptor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FZ6, FZ-6, HFZ6, NDNC10
  • Links
    NCBI Gene ID: 8323
    neXtProt AC: NX_O60353
    UniProt: O60353

  • Chr Location
    8q22.3; chr8:103298433-103332866 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FZD6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 32155 C57BL/6J ±  kb
    transcript ENSMUST00000179165 Ensembl | MGI Sequence Detail 4325 Not Applicable  
    polypeptide ENSMUSP00000136328 Ensembl | MGI Sequence Detail 709 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      277 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 14
      Primer pair 13
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37518
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 67
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257839 Li S, et al., Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. Cell Res. 2018 Feb;28(2):221-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory