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Angpt1 Gene Detail
Summary
  • Symbol
    Angpt1
  • Name
    angiopoietin 1
  • Synonyms
    1110046O21Rik, ang1, Ang-1, Angiopoietin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108448
    NCBI Gene: 11600
  • Gene Overview
    MyGene.info: ANGPT1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:42424723-42676977 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.69 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2415 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108448
protein coding gene Chr15:42424667-42676977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021823
protein coding gene Chr15:41003228-41264983 (-)
A/J MGP_AJ_G0021783
protein coding gene Chr15:39426874-39672287 (-)
AKR/J MGP_AKRJ_G0021764
protein coding gene Chr15:40608171-40861418 (-)
BALB/cJ MGP_BALBcJ_G0021790
protein coding gene Chr15:39485122-39740529 (-)
C3H/HeJ MGP_C3HHeJ_G0021564
protein coding gene Chr15:40502238-40760701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022229
protein coding gene Chr15:42583589-42852603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019766
protein coding gene Chr15:37041980-37275498 (-)
CAST/EiJ MGP_CASTEiJ_G0021081
protein coding gene Chr15:41033697-41296549 (-)
CBA/J MGP_CBAJ_G0021533
protein coding gene Chr15:44051564-44337032 (-)
DBA/2J MGP_DBA2J_G0021657
protein coding gene Chr15:39254921-39503041 (-)
FVB/NJ MGP_FVBNJ_G0021635
protein coding gene Chr15:38573279-38820370 (-)
LP/J MGP_LPJ_G0021727
protein coding gene Chr15:40793432-41051609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021659
protein coding gene Chr15:47124451-47421920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022252
protein coding gene Chr15:40779436-41036855 (-)
PWK/PhJ MGP_PWKPhJ_G0020826
protein coding gene Chr15:39291242-39540222 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020663
protein coding gene Chr15:40427251-40693914 (-)
WSB/EiJ MGP_WSBEiJ_G0021136
protein coding gene Chr15:40677980-40931937 (-)



Homology
more
  • Human Ortholog
    ANGPT1, angiopoietin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPT1, angiopoietin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGP1, AGPT, ANG1
  • Links
    NCBI Gene ID: 284
    neXtProt AC: NX_Q15389
    UniProt: Q15389

  • Chr Location
    8q23.1; chr8:107249482-107498055 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37447
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANGPT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022309 Ensembl Gene Model | MGI Sequence Detail 252255 C57BL/6J ±  kb
    transcript ENSMUST00000022921 Ensembl | MGI Sequence Detail 4260 Not Applicable  
    polypeptide ENSMUSP00000022921 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004023 angiopoietin-1
    • InterPro Domains
      IPR028843 Angiopoietin-1
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 33
      Primer pair 10
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37492, MGI:1916073
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 97
      Gene Ontology 17
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:262224 Yin GN, et al., Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway. Diabetes. 2018 Jun;67(6):1149-1161

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory