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Angpt1 Gene Detail
Summary
  • Symbol
    Angpt1
  • Name
    angiopoietin 1
  • Synonyms
    1110046O21Rik, ang1, Ang-1, Angiopoietin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108448
    NCBI Gene: 11600
  • Gene Overview
    MyGene.info: ANGPT1
Location & Maps
more
  • Sequence Map
    Chr15:42424727-42676977 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      252251 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.69 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    ANGPT1, angiopoietin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPT1, angiopoietin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGP1, AGPT, ANG1
  • Links
    NCBI Gene ID: 284
    neXtProt AC: NX_Q15389

  • Chr Location
    8q23.1; chr8:107249482-107498026 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37447
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANGPT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    2 involving Angpt1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022309 Ensembl Gene Model | MGI Sequence Detail 252251 C57BL/6J ±  kb
transcript ENSMUST00000022921 Ensembl | MGI Sequence Detail 4256 Not Applicable  
polypeptide ENSMUSP00000022921 Ensembl | MGI Sequence Detail 498 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2415 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004023 angiopoietin-1
  • InterPro Domains
    IPR028843 Angiopoietin-1
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
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  • All nucleic 43
    Genomic 1
    cDNA 32
    Primer pair 9
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-37492, MGI:1916073
References
more
  • Summaries
    All 146
    Developmental Gene Expression 91
    Gene Ontology 17
    Phenotypes 22
  • Earliest
    J:37459 Suri C, et al., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [see comments]. Cell. 1996 Dec 27;87(7):1171-80
  • Latest
    J:229467 Zhang KK, et al., Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory