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Angpt1 Gene Detail
Summary
  • Symbol
    Angpt1
  • Name
    angiopoietin 1
  • Synonyms
    1110046O21Rik, ang1, Ang-1, Angiopoietin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108448
    NCBI Gene: 11600
  • Gene Overview
    MyGene.info: ANGPT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:42424723-42676977 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      252255 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.69 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    ANGPT1, angiopoietin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANGPT1, angiopoietin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGP1, AGPT, ANG1
  • Links
    NCBI Gene ID: 284
    neXtProt AC: NX_Q15389
    UniProt: Q15389

  • Chr Location
    8q23.1; chr8:107249482-107498055 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37447
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANGPT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022309 Ensembl Gene Model | MGI Sequence Detail 252255 C57BL/6J ±  kb
    transcript ENSMUST00000022921 Ensembl | MGI Sequence Detail 4260 Not Applicable  
    polypeptide ENSMUSP00000022921 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      2415 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004023 angiopoietin-1
    • InterPro Domains
      IPR028843 Angiopoietin-1
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 32
      Primer pair 10
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37492, MGI:1916073
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 96
      Gene Ontology 17
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257018 Loganathan K, et al., Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice. PLoS One. 2018;13(1):e0189433

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory