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Angpt1
Gene Detail
 Symbol
Name
ID
Angpt1
angiopoietin 1
MGI:108448
Synonyms 1110046O21Rik, ang1, Ang-1, Angiopoietin-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
16.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:42424723-42676795 bp, - strand
From NCBI annotation of GRCm38

  252073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Angpt1

Human
homologs
Human Homolog ANGPT1, angiopoietin 1
NCBI Gene ID 284
neXtProt AC  NX_Q15389
Human Synonyms  AGP1, AGPT, ANG1
Human Chr (Location)  8q23.1; chr8:107249482-107498026 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching.
 
Interactions
Angpt1 interacts with 334 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process activation of transmembrane receptor protein tyrosine kinase activity, angiogenesis, ...
Component extracellular region, extracellular space, ...
Function receptor binding, receptor tyrosine kinase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (68)    Tissues (29)    Images (13)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 17, 20, 21, 22, 23, 25, 27
Assay TypeResults
RNA in situ 10
Northern blot 5
Western blot 6
RT-PCR 47
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(32) Primer pair(9) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022309 (Evidence)
Entrez Gene11600 (Evidence)
UniGene309336
DFCITC1576829, TC1623736, TC1781981
DoTSDT.55234708, DT.94403542
NIA Mouse Gene IndexU036134
Consensus CDS ProjectCCDS27450.1
International Mouse Knockout Project StatusAngpt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11600 NCBI Gene Model | MGI Sequence Detail 252073 C57BL/6J ±  kb
transcript NM_009640 RefSeq | MGI Sequence Detail 4316 C57BL/6 
polypeptide O08538 UniProt | EBI | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(2426 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004023 angiopoietin-1
Graphical View of Protein Domain Structure
References (Earliest) J:37459 Suri C, et al., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [see comments]. Cell. 1996 Dec 27;87(7):1171-80
(Latest) J:203805 Wu SP, et al., Tbx18 regulates development of the epicardium and coronary vessels. Dev Biol. 2013 Nov 15;383(2):307-20
All references(134)
Other
accession IDs
MGD-MRK-37492, MGI:1916073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory