Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables signaling receptor binding activity. Acts upstream of or within several processes, including blood vessel development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to be located in membrane raft; microvillus; and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; liver; metanephros; respiratory system; and yolk sac. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).