GO Annotations Graph

• Symbol: Angpt1
• Name: angiopoietin 1
• ID: MGI:108448

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:262023
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:37460
Molecular Function	GO:0005172	vascular endothelial growth factor receptor binding	TAS	J:53333
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:138423
Biological Process	GO:0001525	angiogenesis	IDA	J:59160
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	TAS	J:169941
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	TAS	J:169941
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0031589	cell-substrate adhesion	IDA	J:51336
Biological Process	GO:0003160	endocardium morphogenesis	TAS	J:169941
Biological Process	GO:0007492	endoderm development	TAS	J:53333
Biological Process	GO:0072012	glomerulus vasculature development	ISO	J:155856
Biological Process	GO:0072012	glomerulus vasculature development	IDA	J:71479
Biological Process	GO:0030097	hemopoiesis	IDA	J:91951
Biological Process	GO:0030210	heparin biosynthetic process	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IGI	J:67322
Biological Process	GO:0001701	in utero embryonic development	IMP	J:67322
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	IDA	J:157867
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:149670
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:149670
Biological Process	GO:0042308	negative regulation of protein import into nucleus	IDA	J:157867
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IDA	J:157867
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0043116	negative regulation of vascular permeability	IDA	J:59160
Biological Process	GO:0043116	negative regulation of vascular permeability	IDA	J:124788
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:149670
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:149670
Biological Process	GO:0001541	ovarian follicle development	ISO	J:155856
Biological Process	GO:0050918	positive chemotaxis	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	IDA	J:91951
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	TAS	J:169941
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:149670
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:149670
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:37460
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:149670
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS	J:164086
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:157867
Biological Process	GO:2000446	regulation of macrophage migration inhibitory factor signaling pathway	IDA	J:157867
Biological Process	GO:0043393	regulation of protein binding	IDA	J:157867
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	ISO	J:164563
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IDA	J:157867
Biological Process	GO:0002040	sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0048014	Tie signaling pathway	ISO	J:164563
Biological Process	GO:0048014	Tie signaling pathway	TAS	J:169941
Biological Process	GO:0048014	Tie signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:37459
Biological Process	GO:0001570	vasculogenesis	TAS	J:169941
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	TAS	J:169941