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Cpeb1 Gene Detail
Summary
  • Symbol
    Cpeb1
  • Name
    cytoplasmic polyadenylation element binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108442
    NCBI Gene: 12877
  • Gene Overview
    MyGene.info: CPEB1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81347026-81455465 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108442
protein coding gene Chr7:81347026-81456936 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032428
protein coding gene Chr7:83403017-83514602 (-)
A/J MGP_AJ_G0032407
protein coding gene Chr7:81434319-81539811 (-)
AKR/J MGP_AKRJ_G0032343
protein coding gene Chr7:83241009-83346550 (-)
BALB/cJ MGP_BALBcJ_G0032419
protein coding gene Chr7:81094943-81200540 (-)
C3H/HeJ MGP_C3HHeJ_G0032132
protein coding gene Chr7:83849762-83959344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032911
protein coding gene Chr7:86670312-86779938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029919
protein coding gene Chr7:83919293-84016801 (-)
CAST/EiJ MGP_CASTEiJ_G0031460
protein coding gene Chr7:74784892-74896122 (-)
CBA/J MGP_CBAJ_G0032098
protein coding gene Chr7:89574004-89690708 (-)
DBA/2J MGP_DBA2J_G0032253
protein coding gene Chr7:79965518-80075178 (-)
FVB/NJ MGP_FVBNJ_G0032208
protein coding gene Chr7:79901937-80015453 (-)
LP/J MGP_LPJ_G0032334
protein coding gene Chr7:84636845-84749642 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032245
protein coding gene Chr7:89639713-89755961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032929
protein coding gene Chr7:82643708-82755899 (-)
PWK/PhJ MGP_PWKPhJ_G0031180
protein coding gene Chr7:73179679-73286380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031021
protein coding gene Chr7:69656635-69762727 (-)
WSB/EiJ MGP_WSBEiJ_G0031578
protein coding gene Chr7:83009111-83118535 (-)



Homology
more
  • Human Ortholog
    CPEB1, cytoplasmic polyadenylation element binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPEB1, cytoplasmic polyadenylation element binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPEB, CPEB-1, CPE-BP1, h-CPEB, hCPEB-1
  • Links
    NCBI Gene ID: 64506
    neXtProt AC: NX_Q9BZB8
    UniProt: Q9BZB8

  • Chr Location
    15q25.2; chr15:82543201-82648016 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and overtly normal but display a developmental arrest of both female and male germ cells at the pachytene stage, defective synaptonemal complex formation, and impaired neuronal synaptic plasticity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025586 Ensembl Gene Model | MGI Sequence Detail 108440 C57BL/6J ±  kb
    transcript ENSMUST00000178892 Ensembl | MGI Sequence Detail 1777 Not Applicable  
    polypeptide ENSMUSP00000137079 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034977 CPEB-1, RNA recognition motif 1
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032292 Cytoplasmic polyadenylation element-binding protein 1, N-terminal
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37486, MGI:2142147
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 12
      Gene Ontology 15
      Phenotypes 19
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:265044 Parras A, et al., Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. 2018 Aug;560(7719):441-446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory