About   Help   FAQ
Cpeb1
Gene Detail
 Symbol
Name
ID
Cpeb1
cytoplasmic polyadenylation element binding protein 1
MGI:108442
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:81347026-81455465 bp, - strand
From VEGA annotation of GRCm38

  108440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytoplasmic polyadenylation element binding protein, type 1
Gene Tree: Cpeb1

Human
homologs
Human Homolog CPEB1, cytoplasmic polyadenylation element binding protein 1
NCBI Gene ID 64506
neXtProt AC  NX_Q9BZB8
Human Synonyms  CEBP, CPEB, CPEB-1, CPE-BP1, hCPEB-1
Human Chr (Location)  15q25.2; chr15:82543198-82648016 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable and overtly normal but display a developmental arrest of both female and male germ cells at the pachytene stage, defective synaptonemal complex formation, and impaired neuronal synaptic plasticity.
 
Interactions
Cpeb1 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular response to amino acid stimulus, cellular response to hypoxia, ...
Component cell junction, cytoplasm, ...
Function metal ion binding, mRNA 3'-UTR AU-rich region binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (67)    Tissues (57)    Images (14)
Theiler Stages: 1, 2, 3, 5, 21, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 49
RT-PCR 17
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024594 (Evidence)
Ensembl Gene ModelENSMUSG00000025586 (Evidence)
Entrez Gene12877 (Evidence)
DFCITC1580339, TC1631052
DoTSDT.532507
NIA Mouse Gene IndexU028778
Consensus CDS ProjectCCDS40007.1, CCDS57557.1
International Mouse Knockout Project StatusCpeb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024594 VEGA Gene Model | MGI Sequence Detail 108440 C57BL/6J ±  kb
transcript OTTMUST00000060424 VEGA | MGI Sequence Detail 3111 Not Applicable 
polypeptide OTTMUSP00000029472 VEGA | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(505 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000005805 cytoplasmic polyadenylation element-binding protein 1
References (Earliest) J:37254 Gebauer F, et al., Mouse cytoplasmic polyadenylylation element binding protein: an evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c-mos mRNA. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14602-7
(Latest) J:203765 Udagawa T, et al., Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med. 2013 Nov;19(11):1473-7
All references(49)
Other
accession IDs
MGD-MRK-37486, MGI:2142147

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory